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• W2806930594 abstract "Abstract Introduction Helicobacter pylori infections affect almost 50% of the world population, constituting a risk factor for benign and malignant gastrointestinal diseases. The increased resistance to antibiotic treatment against this infection represents a dilemma in the search of other therapeutic alternatives. Objective To determine the efficacy of the use of vitamin C and E supplements concomitantly to antibiotic treatment against H. pylori infections. Methods We performed a systematic review on the MedLine (PubMed), Embase and Cochrane Central Register of Clinical Trials (CENTRAL) databases, searching for studies evaluating the efficacy of vitamin C and/or E supplements in the antibiotic treatment of H. pylori infections. The primary outcome was eradication of the infection. The secondary outcome was the adverse effects. The meta-analysis was conducted using the random effects method. Results Ten studies were included and analyzed in two groups. The first group, which was comprised by 973 patients, compared the use of supplementation with vitamin C and E, showing that, without discriminating the number of antibiotics used, there was no relationship with the eradication of the infection (OR: 1.98 [95% CI: 0.92–4.29], p = 0.08). The triple or quadruple antibiotic therapy had no effect on eradication rates either (OR 1.80 [95% CI: 0.64–5.08], p = 0.26 and OR: 2.84 [95% CI: 0.51–15.56], p = 0.22, respectively). No effect on the eradication rates was observed either in the group that only assessed the use of vitamin C, comprised by 702 patients (OR: 1.17 [95% CI: 0.58–2.31], p = 0.65). Only four studies reported adverse effects, the most common one being nausea. Conclusions Supplementation with vitamin C and E in the antibiotic treatment against H. pylori has no effect. However, the reviewed studies had several biases and differences in the dosage of the supplements and antibiotics administered." @default.
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• W2806930594 date "2018-07-01" @default.
• W2806930594 modified "2023-10-17" @default.
• W2806930594 title "Assessment of the use of vitamin C and E supplements concomitantly to antibiotic treatment against Helicobacter pylori : A systematic review and meta-analysis" @default.
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• W2806930594 doi "https://doi.org/10.1016/j.medcle.2018.05.016" @default.
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