Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806963913> ?p ?o ?g. }
- W2806963913 endingPage "214" @default.
- W2806963913 startingPage "204" @default.
- W2806963913 abstract "Metronidazole is a imidazole derivative with antibacterial and antiprotozoal activity. Despite its therapeutic efficacy, several studies have been developing new imidazole derivatives with lower toxicity. Considering that drug-membrane interactions are key factors for drugs pharmacokinetic and pharmacodynamic properties, the aim of this work is to provide new insights into the structure–toxicity relationship of metronidazole within phosphatidylcholine membranes. For that purpose, lipid membrane models (liposomes and monolayers) composed of dipalmitoylphosphatidylcholine were used. Experimental techniques (determination of partition coefficients and Langmuir isotherm measurements) were combined with molecular dynamics simulations. Different pHs and lipid phases were evaluated to enable a better extrapolation for in vivo conditions. The partition of metronidazole depends on the pH and on the biphasic system (octanol/water or DPPC/water system). At pH 1.2, metronidazole is hydrophilic. At pH 7.4, metronidazole disturbs the order and the packing of phospholipids. For this toxic effect, the hydroxyl group of the side chain of metronidazole is crucial by interacting with the water embedded in the membrane and with the phosphate group and the apolar chains of phospholipids." @default.
- W2806963913 created "2018-06-13" @default.
- W2806963913 creator A5011097100 @default.
- W2806963913 creator A5013017184 @default.
- W2806963913 creator A5041458969 @default.
- W2806963913 creator A5042077809 @default.
- W2806963913 creator A5069981575 @default.
- W2806963913 date "2018-08-01" @default.
- W2806963913 modified "2023-10-06" @default.
- W2806963913 title "Metronidazole within phosphatidylcholine lipid membranes: New insights to improve the design of imidazole derivatives" @default.
- W2806963913 cites W1621109547 @default.
- W2806963913 cites W1964758803 @default.
- W2806963913 cites W1966078827 @default.
- W2806963913 cites W1976209618 @default.
- W2806963913 cites W1978498560 @default.
- W2806963913 cites W1981235023 @default.
- W2806963913 cites W1982041242 @default.
- W2806963913 cites W1989753444 @default.
- W2806963913 cites W1989793475 @default.
- W2806963913 cites W1990771438 @default.
- W2806963913 cites W1993177346 @default.
- W2806963913 cites W1997772366 @default.
- W2806963913 cites W2000959972 @default.
- W2806963913 cites W2003418017 @default.
- W2806963913 cites W2007072192 @default.
- W2806963913 cites W2008794906 @default.
- W2806963913 cites W2012004433 @default.
- W2806963913 cites W2022317249 @default.
- W2806963913 cites W2027408247 @default.
- W2806963913 cites W2030327847 @default.
- W2806963913 cites W2034574154 @default.
- W2806963913 cites W2035687084 @default.
- W2806963913 cites W2042709513 @default.
- W2806963913 cites W2046370344 @default.
- W2806963913 cites W2048599811 @default.
- W2806963913 cites W2053837540 @default.
- W2806963913 cites W2055154757 @default.
- W2806963913 cites W2057973387 @default.
- W2806963913 cites W2060433756 @default.
- W2806963913 cites W2066414494 @default.
- W2806963913 cites W2067174909 @default.
- W2806963913 cites W2079433635 @default.
- W2806963913 cites W2080227665 @default.
- W2806963913 cites W2080946353 @default.
- W2806963913 cites W2081693079 @default.
- W2806963913 cites W2081932070 @default.
- W2806963913 cites W2084632517 @default.
- W2806963913 cites W2091402748 @default.
- W2806963913 cites W2095186639 @default.
- W2806963913 cites W2111942462 @default.
- W2806963913 cites W2112154906 @default.
- W2806963913 cites W2138305674 @default.
- W2806963913 cites W2138532798 @default.
- W2806963913 cites W2139824857 @default.
- W2806963913 cites W2141273392 @default.
- W2806963913 cites W2144319155 @default.
- W2806963913 cites W2158391580 @default.
- W2806963913 cites W2158530116 @default.
- W2806963913 cites W2160544821 @default.
- W2806963913 cites W2315970421 @default.
- W2806963913 cites W2321832951 @default.
- W2806963913 cites W2333168323 @default.
- W2806963913 cites W2335028169 @default.
- W2806963913 cites W2559975070 @default.
- W2806963913 cites W2951850759 @default.
- W2806963913 cites W301378022 @default.
- W2806963913 doi "https://doi.org/10.1016/j.ejpb.2018.05.036" @default.
- W2806963913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29859282" @default.
- W2806963913 hasPublicationYear "2018" @default.
- W2806963913 type Work @default.
- W2806963913 sameAs 2806963913 @default.
- W2806963913 citedByCount "11" @default.
- W2806963913 countsByYear W28069639132018 @default.
- W2806963913 countsByYear W28069639132019 @default.
- W2806963913 countsByYear W28069639132020 @default.
- W2806963913 countsByYear W28069639132021 @default.
- W2806963913 countsByYear W28069639132023 @default.
- W2806963913 crossrefType "journal-article" @default.
- W2806963913 hasAuthorship W2806963913A5011097100 @default.
- W2806963913 hasAuthorship W2806963913A5013017184 @default.
- W2806963913 hasAuthorship W2806963913A5041458969 @default.
- W2806963913 hasAuthorship W2806963913A5042077809 @default.
- W2806963913 hasAuthorship W2806963913A5069981575 @default.
- W2806963913 hasConcept C178790620 @default.
- W2806963913 hasConcept C185154212 @default.
- W2806963913 hasConcept C185592680 @default.
- W2806963913 hasConcept C192552737 @default.
- W2806963913 hasConcept C201399114 @default.
- W2806963913 hasConcept C202751555 @default.
- W2806963913 hasConcept C21951064 @default.
- W2806963913 hasConcept C2776330855 @default.
- W2806963913 hasConcept C2776635100 @default.
- W2806963913 hasConcept C2777396551 @default.
- W2806963913 hasConcept C2778918659 @default.
- W2806963913 hasConcept C2781172473 @default.
- W2806963913 hasConcept C41625074 @default.
- W2806963913 hasConcept C43617362 @default.
- W2806963913 hasConcept C501593827 @default.