FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806968612> ?p ?o ?g. }

• W2806968612 abstract "Characterization of the Mycobacterium leprae genome has made possible the development of Polymerase Chain Reaction (PCR) systems that can amplify different genomic regions. Increased reliability and technical efficiency of quantitative PCR (qPCR) makes it a promising tool for early diagnosis of leprosy. Index cases that are multibacillary spread the bacillus silently, even before they are clinically diagnosed. Early detection and treatment could prevent transmission in endemic areas.In this study, the qPCR technique is used to detect DNA of M. leprae in samples of slit skin smears (SSS) of the ear lobe and blood of leprosy patients and their asymptomatic household contacts residing in Governador Valadares, MG, Brazil, a hyperendemic area for leprosy. A total of 164 subjects participated in the study: 43 index cases, 113 household contacts, and, as negative controls, 8 individuals who reported no contact with patients nor history of leprosy in the family. The qPCR was performed to amplify 16S rRNA fragments and was specifically designed for M. leprae.Of asymptomatic household contacts, 23.89% showed bacillary DNA by qPCR in samples of SSS and blood. Also, 48.84% of patients diagnosed with leprosy were positive for qPCR while the bacillary load was positive in only 30.23% of patients. It is important to note that most patients were already receiving treatment when the collection of biological material for qPCR was performed. The level of bacillary DNA from household contacts was similar to the DNA levels detected in the group of paucibacillary patients.Considering that household contacts comprise a recognizable group of individuals with a high risk of disease, as they live in close proximity to a source of infection, qPCR can be used to estimate the risk of progress towards leprosy among household contacts and as a routine screening method for a chemoprophylactic protocol." @default.
• W2806968612 created "2018-06-13" @default.
• W2806968612 creator A5001761514 @default.
• W2806968612 creator A5015384058 @default.
• W2806968612 creator A5020546900 @default.
• W2806968612 creator A5022115117 @default.
• W2806968612 creator A5038022111 @default.
• W2806968612 creator A5040190247 @default.
• W2806968612 creator A5042080731 @default.
• W2806968612 creator A5060077070 @default.
• W2806968612 creator A5062001613 @default.
• W2806968612 creator A5065691817 @default.
• W2806968612 creator A5065799573 @default.
• W2806968612 date "2018-04-02" @default.
• W2806968612 modified "2023-10-18" @default.
• W2806968612 title "High frequency of M. leprae DNA detection in asymptomatic household contacts" @default.
• W2806968612 cites W1009136621 @default.
• W2806968612 cites W1782154334 @default.
• W2806968612 cites W1885620486 @default.
• W2806968612 cites W1971965419 @default.
• W2806968612 cites W1973620424 @default.
• W2806968612 cites W1976827058 @default.
• W2806968612 cites W1986831440 @default.
• W2806968612 cites W199272327 @default.
• W2806968612 cites W2003393169 @default.
• W2806968612 cites W2010586126 @default.
• W2806968612 cites W2033112850 @default.
• W2806968612 cites W2085444158 @default.
• W2806968612 cites W2089857811 @default.
• W2806968612 cites W2108466723 @default.
• W2806968612 cites W21179917 @default.
• W2806968612 cites W2118827468 @default.
• W2806968612 cites W2119606466 @default.
• W2806968612 cites W2127871522 @default.
• W2806968612 cites W2138386305 @default.
• W2806968612 cites W2150513905 @default.
• W2806968612 cites W2153538318 @default.
• W2806968612 cites W2178059193 @default.
• W2806968612 cites W2345032258 @default.
• W2806968612 cites W2394647943 @default.
• W2806968612 cites W2438827823 @default.
• W2806968612 cites W4300330185 @default.
• W2806968612 doi "https://doi.org/10.1186/s12879-018-3056-2" @default.
• W2806968612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5879567" @default.
• W2806968612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29609530" @default.
• W2806968612 hasPublicationYear "2018" @default.
• W2806968612 type Work @default.
• W2806968612 sameAs 2806968612 @default.
• W2806968612 citedByCount "23" @default.
• W2806968612 countsByYear W28069686122018 @default.
• W2806968612 countsByYear W28069686122019 @default.
• W2806968612 countsByYear W28069686122020 @default.
• W2806968612 countsByYear W28069686122021 @default.
• W2806968612 countsByYear W28069686122022 @default.
• W2806968612 countsByYear W28069686122023 @default.
• W2806968612 crossrefType "journal-article" @default.
• W2806968612 hasAuthorship W2806968612A5001761514 @default.
• W2806968612 hasAuthorship W2806968612A5015384058 @default.
• W2806968612 hasAuthorship W2806968612A5020546900 @default.
• W2806968612 hasAuthorship W2806968612A5022115117 @default.
• W2806968612 hasAuthorship W2806968612A5038022111 @default.
• W2806968612 hasAuthorship W2806968612A5040190247 @default.
• W2806968612 hasAuthorship W2806968612A5042080731 @default.
• W2806968612 hasAuthorship W2806968612A5060077070 @default.
• W2806968612 hasAuthorship W2806968612A5062001613 @default.
• W2806968612 hasAuthorship W2806968612A5065691817 @default.
• W2806968612 hasAuthorship W2806968612A5065799573 @default.
• W2806968612 hasBestOaLocation W28069686121 @default.
• W2806968612 hasConcept C104317684 @default.
• W2806968612 hasConcept C126322002 @default.
• W2806968612 hasConcept C135763542 @default.
• W2806968612 hasConcept C142724271 @default.
• W2806968612 hasConcept C190139176 @default.
• W2806968612 hasConcept C190612196 @default.
• W2806968612 hasConcept C203014093 @default.
• W2806968612 hasConcept C2777910003 @default.
• W2806968612 hasConcept C2779823659 @default.
• W2806968612 hasConcept C2780695269 @default.
• W2806968612 hasConcept C31467283 @default.
• W2806968612 hasConcept C48023723 @default.
• W2806968612 hasConcept C49105822 @default.
• W2806968612 hasConcept C54355233 @default.
• W2806968612 hasConcept C71924100 @default.
• W2806968612 hasConcept C86803240 @default.
• W2806968612 hasConceptScore W2806968612C104317684 @default.
• W2806968612 hasConceptScore W2806968612C126322002 @default.
• W2806968612 hasConceptScore W2806968612C135763542 @default.
• W2806968612 hasConceptScore W2806968612C142724271 @default.
• W2806968612 hasConceptScore W2806968612C190139176 @default.
• W2806968612 hasConceptScore W2806968612C190612196 @default.
• W2806968612 hasConceptScore W2806968612C203014093 @default.
• W2806968612 hasConceptScore W2806968612C2777910003 @default.
• W2806968612 hasConceptScore W2806968612C2779823659 @default.
• W2806968612 hasConceptScore W2806968612C2780695269 @default.
• W2806968612 hasConceptScore W2806968612C31467283 @default.
• W2806968612 hasConceptScore W2806968612C48023723 @default.
• W2806968612 hasConceptScore W2806968612C49105822 @default.
• W2806968612 hasConceptScore W2806968612C54355233 @default.
• W2806968612 hasConceptScore W2806968612C71924100 @default.
• W2806968612 hasConceptScore W2806968612C86803240 @default.

• next