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• W2806970710 abstract "Objective: To assess the efficacy of a mixed intervention, educational and reminder calendar of the intake, as a strategy to improve therapeutic compliance with dabigatran in patients with non-valvular atrial fibrillation (NVAF). Design and method: Prospective, longitudinal, multicenter study, carried out in 110 specialized healthcare centers in Spain. 726 patients treated with dabigatran prescribed for stroke prevention were included. A cluster randomization was performed based on two groups: 1) Control Group (CG) as usual clinical practice and Intervention Group (IG) with a mixed strategy: a) Healthcare education and b) Use of a reminder calendar for taking the anticoagulant medication. Three visits took place: baseline and follow up at 6 and 12 months. Compliance was measured using electronic monitors (Medication Event Monitoring System - MEMS). Average compliance percentage (%; Average CP) and daily compliance (%; Daily CP) was calculated. A patient was considered complier when CP was 80–100%. Results: Six hundred twenty-five patients ended the study. There were 315 evaluable subjects in the IG and 310 in the CG, with a mean age of 73,52 ± 8,3 years and 73,32 ± 8,56 respectively. Daily CP was 91,97 % at 6 months and 91,05 % after 12 months in the IG and 82,26 % and 82,63 % in the CG. Average compliance was 90,79 % and 89,20 % in the IG and 64,51 % and 63,22 % in the CG at 6 and 12 months respectively. Significant differences were observed in the Daily CP and Average CP with higher percentages in IG. In the non-compliers group, the number of concomitant drugs, baseline and 6 months SBP values, 6 and 12 months DBP values, baseline, 6 and 12 month weight, and total cholesterol and LDL cholesterol at baseline, 6 and 12 months were significantly higher. The number needed to treat (NNT) at the end of the intervention was 3,84 patients to prevent 1 non-compliance. Conclusions: A mixed intervention with educational and reminder calendar of drug intake, has been proven to be effective as a strategy to improve therapeutic compliance with dabigatran in patients with NVAF. The percentage of compliance with dabigatran was high" @default.
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• W2806970710 date "2018-06-01" @default.
• W2806970710 modified "2023-10-18" @default.
• W2806970710 title "IMPROVING THERAPEUTIC COMPLIANCE OF DABIGATRAN IN PREVENTING STROKE IN PATIENTS WITH NON-VALVULAR ATRIAL FIBRILLATION" @default.
• W2806970710 doi "https://doi.org/10.1097/01.hjh.0000539136.41129.0b" @default.
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