Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806973417> ?p ?o ?g. }
- W2806973417 endingPage "53" @default.
- W2806973417 startingPage "43" @default.
- W2806973417 abstract "Abstract Arginine is one of the most versatile semi-essential amino acids. Further to the primary role in protein biosynthesis, arginine is involved in the urea cycle, and it is a precursor of nitric oxide. Arginine deficiency is associated with neurodegenerative diseases such as Parkinson’s, Huntington’s and Alzheimer’s diseases (AD). In this study, we administer arginine intracerebroventricularly in a murine model of AD and evaluate cognitive functions in a set of behavioral tests. In addition, the effect of arginine on synaptic plasticity was tested electrophysiologically by assessment of the hippocampal long-term potentiation (LTP). The effect of arginine on β amyloidosis was tested immunohistochemically. A role of arginine in the prevention of cytotoxicity and apoptosis was evaluated in vitro on PC-12 cells. The results indicate that intracerebroventricular administration of arginine improves spatial memory acquisition in 3xTg-AD mice, however, without significantly reducing intraneuronal β amyloidosis. Arginine shows little or no impact on LTP and does not rescue LTP deterioration induced by Aβ. Nevertheless, arginine possesses neuroprotective and antiapoptotic properties." @default.
- W2806973417 created "2018-06-13" @default.
- W2806973417 creator A5001115009 @default.
- W2806973417 creator A5019184542 @default.
- W2806973417 creator A5027372594 @default.
- W2806973417 creator A5055663605 @default.
- W2806973417 creator A5061309675 @default.
- W2806973417 creator A5089800773 @default.
- W2806973417 date "2018-05-31" @default.
- W2806973417 modified "2023-10-04" @default.
- W2806973417 title "Intracerebroventricular administration of L-arginine improves spatial memory acquisition in triple transgenic mice via reduction of oxidative stress and apoptosis" @default.
- W2806973417 cites W1472536133 @default.
- W2806973417 cites W1492443634 @default.
- W2806973417 cites W1584137212 @default.
- W2806973417 cites W1608104892 @default.
- W2806973417 cites W1964696575 @default.
- W2806973417 cites W1966525844 @default.
- W2806973417 cites W1967464880 @default.
- W2806973417 cites W1977958644 @default.
- W2806973417 cites W1978451224 @default.
- W2806973417 cites W1993993136 @default.
- W2806973417 cites W2003631236 @default.
- W2806973417 cites W2004371621 @default.
- W2806973417 cites W2011233979 @default.
- W2806973417 cites W201336786 @default.
- W2806973417 cites W2014188089 @default.
- W2806973417 cites W2015036130 @default.
- W2806973417 cites W2015671168 @default.
- W2806973417 cites W2026547060 @default.
- W2806973417 cites W2028911700 @default.
- W2806973417 cites W2033835146 @default.
- W2806973417 cites W2040336122 @default.
- W2806973417 cites W2041255286 @default.
- W2806973417 cites W2047455456 @default.
- W2806973417 cites W2056126207 @default.
- W2806973417 cites W2058006909 @default.
- W2806973417 cites W2060246330 @default.
- W2806973417 cites W2065014046 @default.
- W2806973417 cites W2066241164 @default.
- W2806973417 cites W2067261577 @default.
- W2806973417 cites W2071068165 @default.
- W2806973417 cites W2074740395 @default.
- W2806973417 cites W2078380411 @default.
- W2806973417 cites W2087011206 @default.
- W2806973417 cites W2101861123 @default.
- W2806973417 cites W2144382886 @default.
- W2806973417 cites W2151288054 @default.
- W2806973417 cites W2152484512 @default.
- W2806973417 cites W2159157497 @default.
- W2806973417 cites W2172296189 @default.
- W2806973417 cites W2175835252 @default.
- W2806973417 cites W2267499428 @default.
- W2806973417 cites W237380194 @default.
- W2806973417 cites W2425513892 @default.
- W2806973417 cites W2461948858 @default.
- W2806973417 cites W2525820145 @default.
- W2806973417 cites W4252157436 @default.
- W2806973417 cites W48248669 @default.
- W2806973417 doi "https://doi.org/10.1515/tnsci-2018-0009" @default.
- W2806973417 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5984558" @default.
- W2806973417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29876138" @default.
- W2806973417 hasPublicationYear "2018" @default.
- W2806973417 type Work @default.
- W2806973417 sameAs 2806973417 @default.
- W2806973417 citedByCount "19" @default.
- W2806973417 countsByYear W28069734172018 @default.
- W2806973417 countsByYear W28069734172019 @default.
- W2806973417 countsByYear W28069734172020 @default.
- W2806973417 countsByYear W28069734172021 @default.
- W2806973417 countsByYear W28069734172022 @default.
- W2806973417 countsByYear W28069734172023 @default.
- W2806973417 crossrefType "journal-article" @default.
- W2806973417 hasAuthorship W2806973417A5001115009 @default.
- W2806973417 hasAuthorship W2806973417A5019184542 @default.
- W2806973417 hasAuthorship W2806973417A5027372594 @default.
- W2806973417 hasAuthorship W2806973417A5055663605 @default.
- W2806973417 hasAuthorship W2806973417A5061309675 @default.
- W2806973417 hasAuthorship W2806973417A5089800773 @default.
- W2806973417 hasBestOaLocation W28069734171 @default.
- W2806973417 hasConcept C102230213 @default.
- W2806973417 hasConcept C104317684 @default.
- W2806973417 hasConcept C126322002 @default.
- W2806973417 hasConcept C141035611 @default.
- W2806973417 hasConcept C148762608 @default.
- W2806973417 hasConcept C169760540 @default.
- W2806973417 hasConcept C170493617 @default.
- W2806973417 hasConcept C185592680 @default.
- W2806973417 hasConcept C190283241 @default.
- W2806973417 hasConcept C25274449 @default.
- W2806973417 hasConcept C25498285 @default.
- W2806973417 hasConcept C2776151105 @default.
- W2806973417 hasConcept C2777468819 @default.
- W2806973417 hasConcept C2781161787 @default.
- W2806973417 hasConcept C515207424 @default.
- W2806973417 hasConcept C519581460 @default.
- W2806973417 hasConcept C55493867 @default.
- W2806973417 hasConcept C71924100 @default.
- W2806973417 hasConcept C86803240 @default.