FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806983557> ?p ?o ?g. }

• W2806983557 endingPage "126" @default.
• W2806983557 startingPage "116" @default.
• W2806983557 abstract "DNA editing using CRISPR/Cas has emerged as a potential treatment for diseases caused by pathogenic human DNA viruses. One potential target is HIV-1, which replicates via a chromosomally integrated DNA provirus. While CRISPR/Cas can protect T cells from de novo HIV-1 infection, HIV-1 frequently becomes resistant due to mutations in the chosen single guide RNA (sgRNA) target site. To address this problem, we asked whether an sgRNA targeted to a conserved, functionally critical HIV-1 sequence might prevent the selection of escape mutants. We report that two sgRNAs specific for the HIV-1 transactivation response (TAR) element produce opposite results: the TAR2 sgRNA rapidly selects for mutants that retain TAR function, but are no longer inhibited by Cas9, while the TAR1 sgRNA fails to select any replication competent TAR mutants, most probably because it is targeted to a region of TAR that is disrupted by even minor mutations." @default.
• W2806983557 created "2018-06-13" @default.
• W2806983557 creator A5005744857 @default.
• W2806983557 creator A5016365051 @default.
• W2806983557 creator A5045067166 @default.
• W2806983557 creator A5066041195 @default.
• W2806983557 date "2018-07-01" @default.
• W2806983557 modified "2023-09-26" @default.
• W2806983557 title "Insights into the mechanisms underlying the inactivation of HIV-1 proviruses by CRISPR/Cas" @default.
• W2806983557 cites W100663553 @default.
• W2806983557 cites W1564126799 @default.
• W2806983557 cites W1712890974 @default.
• W2806983557 cites W1875322831 @default.
• W2806983557 cites W1964916693 @default.
• W2806983557 cites W1966452674 @default.
• W2806983557 cites W1967737680 @default.
• W2806983557 cites W1973260880 @default.
• W2806983557 cites W1975110258 @default.
• W2806983557 cites W1978917197 @default.
• W2806983557 cites W1996788258 @default.
• W2806983557 cites W2003171404 @default.
• W2806983557 cites W2004729775 @default.
• W2806983557 cites W2031211461 @default.
• W2806983557 cites W2049490177 @default.
• W2806983557 cites W2053542738 @default.
• W2806983557 cites W2062521268 @default.
• W2806983557 cites W2064815984 @default.
• W2806983557 cites W2066457589 @default.
• W2806983557 cites W2075688547 @default.
• W2806983557 cites W2084364085 @default.
• W2806983557 cites W2088474579 @default.
• W2806983557 cites W2106448245 @default.
• W2806983557 cites W2107277218 @default.
• W2806983557 cites W2149407932 @default.
• W2806983557 cites W2171425914 @default.
• W2806983557 cites W2291052616 @default.
• W2806983557 cites W2313699058 @default.
• W2806983557 cites W2319061195 @default.
• W2806983557 cites W2460590072 @default.
• W2806983557 cites W2465403665 @default.
• W2806983557 cites W2469238969 @default.
• W2806983557 cites W2563525476 @default.
• W2806983557 cites W2587082420 @default.
• W2806983557 cites W2790279538 @default.
• W2806983557 doi "https://doi.org/10.1016/j.virol.2018.05.016" @default.
• W2806983557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6100742" @default.
• W2806983557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29857168" @default.
• W2806983557 hasPublicationYear "2018" @default.
• W2806983557 type Work @default.
• W2806983557 sameAs 2806983557 @default.
• W2806983557 citedByCount "24" @default.
• W2806983557 countsByYear W28069835572018 @default.
• W2806983557 countsByYear W28069835572019 @default.
• W2806983557 countsByYear W28069835572020 @default.
• W2806983557 countsByYear W28069835572021 @default.
• W2806983557 countsByYear W28069835572022 @default.
• W2806983557 countsByYear W28069835572023 @default.
• W2806983557 crossrefType "journal-article" @default.
• W2806983557 hasAuthorship W2806983557A5005744857 @default.
• W2806983557 hasAuthorship W2806983557A5016365051 @default.
• W2806983557 hasAuthorship W2806983557A5045067166 @default.
• W2806983557 hasAuthorship W2806983557A5066041195 @default.
• W2806983557 hasBestOaLocation W28069835572 @default.
• W2806983557 hasConcept C102906071 @default.
• W2806983557 hasConcept C104317684 @default.
• W2806983557 hasConcept C132455925 @default.
• W2806983557 hasConcept C141231307 @default.
• W2806983557 hasConcept C143065580 @default.
• W2806983557 hasConcept C144501496 @default.
• W2806983557 hasConcept C159047783 @default.
• W2806983557 hasConcept C189819185 @default.
• W2806983557 hasConcept C501734568 @default.
• W2806983557 hasConcept C54355233 @default.
• W2806983557 hasConcept C552990157 @default.
• W2806983557 hasConcept C67705224 @default.
• W2806983557 hasConcept C70721500 @default.
• W2806983557 hasConcept C86803240 @default.
• W2806983557 hasConcept C97702854 @default.
• W2806983557 hasConcept C98108389 @default.
• W2806983557 hasConceptScore W2806983557C102906071 @default.
• W2806983557 hasConceptScore W2806983557C104317684 @default.
• W2806983557 hasConceptScore W2806983557C132455925 @default.
• W2806983557 hasConceptScore W2806983557C141231307 @default.
• W2806983557 hasConceptScore W2806983557C143065580 @default.
• W2806983557 hasConceptScore W2806983557C144501496 @default.
• W2806983557 hasConceptScore W2806983557C159047783 @default.
• W2806983557 hasConceptScore W2806983557C189819185 @default.
• W2806983557 hasConceptScore W2806983557C501734568 @default.
• W2806983557 hasConceptScore W2806983557C54355233 @default.
• W2806983557 hasConceptScore W2806983557C552990157 @default.
• W2806983557 hasConceptScore W2806983557C67705224 @default.
• W2806983557 hasConceptScore W2806983557C70721500 @default.
• W2806983557 hasConceptScore W2806983557C86803240 @default.
• W2806983557 hasConceptScore W2806983557C97702854 @default.
• W2806983557 hasConceptScore W2806983557C98108389 @default.
• W2806983557 hasLocation W28069835571 @default.
• W2806983557 hasLocation W28069835572 @default.
• W2806983557 hasLocation W28069835573 @default.

• next