FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807011744> ?p ?o ?g. }

• W2807011744 abstract "Both pathogenic bacteria and fungi are developing resistance to common antimicrobial treatment at an alarming rate. To counteract this development, it is of essence to develop new classes of antimicrobial agents. One such class is antimicrobial peptides, most of which are derived from the innate immune system. In this study, a series of novel 2,5‐diketopiperazines were designed, synthesized, and evaluated for their antimicrobial abilities. The compounds were designed to probe the pharmacophore dictated for short linear mimics of antimicrobial cationic peptides, and as such, the compounds contain a range of cationic and hydrophobic functionalities. Several of the prepared compounds displayed high antimicrobial activities toward bacteria and also against human pathogenic fungi. Of particular interest was the high activity toward fungal strains with an inherent increased resistance toward conventional antifungal agents. The most effective compounds displayed inhibition of Candida glabrata and Candida krusei growth at concentrations between 4 and 8 μg/mL, which is comparable to commercial antifungal agents in use. Structure activity relationship studies revealed a similar dependence on cationic charge and the volume of the hydrophobic bulk as for linear cationic antimicrobial peptides. Finally, the hemolytic activity of selected compounds was evaluated, which revealed a potential to produce active compounds with attenuation of unwanted hemolysis. The findings highlight the potential of cyclic cationic amphiphilic peptidomimetics as a class of promising compounds for the treatment of infections caused by microorganisms with an increased resistance to conventional antimicrobial agents." @default.
• W2807011744 created "2018-06-13" @default.
• W2807011744 creator A5016287970 @default.
• W2807011744 creator A5021165678 @default.
• W2807011744 creator A5050397465 @default.
• W2807011744 creator A5053510806 @default.
• W2807011744 creator A5056118794 @default.
• W2807011744 creator A5061403166 @default.
• W2807011744 creator A5070353730 @default.
• W2807011744 creator A5084763873 @default.
• W2807011744 date "2018-05-29" @default.
• W2807011744 modified "2023-09-27" @default.
• W2807011744 title "Development and evaluation of cationic amphiphilic antimicrobial 2,5-diketopiperazines" @default.
• W2807011744 cites W12653918 @default.
• W2807011744 cites W1498823518 @default.
• W2807011744 cites W1525374801 @default.
• W2807011744 cites W1583034884 @default.
• W2807011744 cites W1860382351 @default.
• W2807011744 cites W1965015032 @default.
• W2807011744 cites W1968431375 @default.
• W2807011744 cites W1973424879 @default.
• W2807011744 cites W1979973356 @default.
• W2807011744 cites W1981664793 @default.
• W2807011744 cites W1982746862 @default.
• W2807011744 cites W1992937762 @default.
• W2807011744 cites W1993917762 @default.
• W2807011744 cites W1996137497 @default.
• W2807011744 cites W1998602558 @default.
• W2807011744 cites W1998839795 @default.
• W2807011744 cites W1999809919 @default.
• W2807011744 cites W2004974187 @default.
• W2807011744 cites W2012166418 @default.
• W2807011744 cites W2018382434 @default.
• W2807011744 cites W2022939277 @default.
• W2807011744 cites W2025764419 @default.
• W2807011744 cites W2030568234 @default.
• W2807011744 cites W2032264027 @default.
• W2807011744 cites W2033329054 @default.
• W2807011744 cites W2038859326 @default.
• W2807011744 cites W2040310992 @default.
• W2807011744 cites W2053155418 @default.
• W2807011744 cites W2056926089 @default.
• W2807011744 cites W2059485166 @default.
• W2807011744 cites W2065430267 @default.
• W2807011744 cites W2065963000 @default.
• W2807011744 cites W2075518165 @default.
• W2807011744 cites W2079468421 @default.
• W2807011744 cites W2079665383 @default.
• W2807011744 cites W2079688630 @default.
• W2807011744 cites W2082302827 @default.
• W2807011744 cites W2092144401 @default.
• W2807011744 cites W2092398381 @default.
• W2807011744 cites W2094210743 @default.
• W2807011744 cites W2098422570 @default.
• W2807011744 cites W2099042559 @default.
• W2807011744 cites W2102567112 @default.
• W2807011744 cites W2114921798 @default.
• W2807011744 cites W2115372426 @default.
• W2807011744 cites W2116757372 @default.
• W2807011744 cites W2121417680 @default.
• W2807011744 cites W2121652784 @default.
• W2807011744 cites W2131636532 @default.
• W2807011744 cites W2141563676 @default.
• W2807011744 cites W2144149632 @default.
• W2807011744 cites W2159256196 @default.
• W2807011744 cites W2159861471 @default.
• W2807011744 cites W2164721742 @default.
• W2807011744 cites W2166075607 @default.
• W2807011744 cites W2168442227 @default.
• W2807011744 cites W2168781246 @default.
• W2807011744 cites W2171155970 @default.
• W2807011744 cites W2252622713 @default.
• W2807011744 cites W2314787980 @default.
• W2807011744 cites W2315594095 @default.
• W2807011744 cites W2319017667 @default.
• W2807011744 cites W2507333769 @default.
• W2807011744 cites W2516616885 @default.
• W2807011744 cites W2519386640 @default.
• W2807011744 cites W2567048109 @default.
• W2807011744 cites W2594809346 @default.
• W2807011744 cites W2604779599 @default.
• W2807011744 cites W2605235260 @default.
• W2807011744 cites W2621516744 @default.
• W2807011744 cites W2752567037 @default.
• W2807011744 cites W2950347146 @default.
• W2807011744 cites W2950503578 @default.
• W2807011744 doi "https://doi.org/10.1002/psc.3090" @default.
• W2807011744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29845683" @default.
• W2807011744 hasPublicationYear "2018" @default.
• W2807011744 type Work @default.
• W2807011744 sameAs 2807011744 @default.
• W2807011744 citedByCount "15" @default.
• W2807011744 countsByYear W28070117442019 @default.
• W2807011744 countsByYear W28070117442020 @default.
• W2807011744 countsByYear W28070117442021 @default.
• W2807011744 countsByYear W28070117442022 @default.
• W2807011744 countsByYear W28070117442023 @default.
• W2807011744 crossrefType "journal-article" @default.
• W2807011744 hasAuthorship W2807011744A5016287970 @default.
• W2807011744 hasAuthorship W2807011744A5021165678 @default.

• next