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- W2807024618 abstract "Absence epilepsy is characterized by a sudden paroxysmal loss of consciousness accompanied by oscillations of activity propagating over many brain areas. Although the primary generalized absence seizures are traditionally underlain by the global corticothalamic system, converging experimental evidence supports the focal theory of absence epilepsy. Here a theory is proposed to unify both global and focal aspects of absence epilepsy in a physiology-based corticothalamic model with spatial heterogeneity representing an initial seizure focus, emphasizing the effect of local cortical connectivity and cortical propagation. Numerical simulations and analytical calculations are combined to investigate the emergent spatiotemporal dynamics induced by the seizure focus as well as their underlying dynamical mechanisms. The results categorize the spatiotemporal dynamics into three scenarios: seizure suppression, seizure localization and seizure generalization, where robust self-organized waves agree well with experimental wave rhythms and spatial extensions during seizures for global and focal aspects, respectively. Our findings provide a biophysical and mechanistic explanation of higher frequency and amplitude of the waves observed in genetic rat models with absence epilepsy, and imply that global and focal absence epilepsy could be unified in the framework of pathological pattern formation. Predictions are also presented for future experimental tests." @default.
- W2807024618 created "2018-06-13" @default.
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- W2807024618 date "2018-06-05" @default.
- W2807024618 modified "2023-09-23" @default.
- W2807024618 title "Pathological Pattern Formation in Absence Epilepsy: A Theoretical Framework to Unify Global and Focal Aspects" @default.
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