FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807075107> ?p ?o ?g. }

• W2807075107 abstract "The 21-gene Recurrence Score (RS) result predicts outcome and chemotherapy benefit in node-negative and node-positive (N+), estrogen receptor-positive (ER+) patients treated with endocrine therapy. The purpose of this study was to evaluate the prognostic impact of RS results in N+, hormone receptor-positive (HR+) patients treated with adjuvant chemotherapy (6 cycles of FEC100 vs. 3 cycles of FEC100 followed by 3 cycles of docetaxel 100 mg/m2) plus endocrine therapy (ET) in the PACS-01 trial (J Clin Oncol 2006;24:5664-5671).The current study included 530 HR+/N+ patients from the PACS-01 parent trial for whom specimens were available. The primary objective was to evaluate the relationship between the RS result and distant recurrence (DR).There were 209 (39.4%) patients with low RS (< 18), 159 (30%) with intermediate RS (18-30) and 162 (30.6%) with high RS (≥ 31). The continuous RS result was associated with DR (hazard ratio = 4.14; 95% confidence interval: 2.67-6.43; p < 0.001), adjusting for treatment. In multivariable analysis, the RS result remained a significant predictor of DR (p < 0.001) after adjustment for number of positive nodes, tumor size, tumor grade, Ki-67 (immunohistochemical status), and chemotherapy regimen. There was no statistically significant interaction between RS result and treatment in predicting DR (p = 0.79).After adjustment for clinical covariates, the 21-gene RS result is a significant prognostic factor in N+/HR+ patients receiving adjuvant chemoendocrine therapy.Not applicable." @default.
• W2807075107 created "2018-06-13" @default.
• W2807075107 creator A5003424696 @default.
• W2807075107 creator A5011227048 @default.
• W2807075107 creator A5012804079 @default.
• W2807075107 creator A5013759812 @default.
• W2807075107 creator A5034232647 @default.
• W2807075107 creator A5048859997 @default.
• W2807075107 creator A5052648400 @default.
• W2807075107 creator A5052800490 @default.
• W2807075107 creator A5061340891 @default.
• W2807075107 creator A5062981484 @default.
• W2807075107 creator A5073011726 @default.
• W2807075107 creator A5078606543 @default.
• W2807075107 creator A5082566756 @default.
• W2807075107 creator A5086838488 @default.
• W2807075107 creator A5091592799 @default.
• W2807075107 date "2018-05-04" @default.
• W2807075107 modified "2023-09-26" @default.
• W2807075107 title "The 21-gene Recurrence Score® assay predicts distant recurrence in lymph node-positive, hormone receptor-positive, breast cancer patients treated with adjuvant sequential epirubicin- and docetaxel-based or epirubicin-based chemotherapy (PACS-01 trial)" @default.
• W2807075107 cites W1551461559 @default.
• W2807075107 cites W2075213874 @default.
• W2807075107 cites W2078667073 @default.
• W2807075107 cites W2084370697 @default.
• W2807075107 cites W2085835360 @default.
• W2807075107 cites W2091205535 @default.
• W2807075107 cites W2091599823 @default.
• W2807075107 cites W2098333537 @default.
• W2807075107 cites W2105882193 @default.
• W2807075107 cites W2113344831 @default.
• W2807075107 cites W2113769864 @default.
• W2807075107 cites W2119438951 @default.
• W2807075107 cites W2127118871 @default.
• W2807075107 cites W2127232551 @default.
• W2807075107 cites W2128985829 @default.
• W2807075107 cites W2129859749 @default.
• W2807075107 cites W2130639106 @default.
• W2807075107 cites W2131994307 @default.
• W2807075107 cites W2139306864 @default.
• W2807075107 cites W2160377567 @default.
• W2807075107 cites W2160450758 @default.
• W2807075107 cites W2289933199 @default.
• W2807075107 cites W2402051962 @default.
• W2807075107 cites W2410853227 @default.
• W2807075107 cites W2728077452 @default.
• W2807075107 cites W2768080316 @default.
• W2807075107 cites W41523064 @default.
• W2807075107 doi "https://doi.org/10.1186/s12885-018-4331-8" @default.
• W2807075107 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5936023" @default.
• W2807075107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29728098" @default.
• W2807075107 hasPublicationYear "2018" @default.
• W2807075107 type Work @default.
• W2807075107 sameAs 2807075107 @default.
• W2807075107 citedByCount "21" @default.
• W2807075107 countsByYear W28070751072018 @default.
• W2807075107 countsByYear W28070751072019 @default.
• W2807075107 countsByYear W28070751072020 @default.
• W2807075107 countsByYear W28070751072021 @default.
• W2807075107 countsByYear W28070751072022 @default.
• W2807075107 countsByYear W28070751072023 @default.
• W2807075107 crossrefType "journal-article" @default.
• W2807075107 hasAuthorship W2807075107A5003424696 @default.
• W2807075107 hasAuthorship W2807075107A5011227048 @default.
• W2807075107 hasAuthorship W2807075107A5012804079 @default.
• W2807075107 hasAuthorship W2807075107A5013759812 @default.
• W2807075107 hasAuthorship W2807075107A5034232647 @default.
• W2807075107 hasAuthorship W2807075107A5048859997 @default.
• W2807075107 hasAuthorship W2807075107A5052648400 @default.
• W2807075107 hasAuthorship W2807075107A5052800490 @default.
• W2807075107 hasAuthorship W2807075107A5061340891 @default.
• W2807075107 hasAuthorship W2807075107A5062981484 @default.
• W2807075107 hasAuthorship W2807075107A5073011726 @default.
• W2807075107 hasAuthorship W2807075107A5078606543 @default.
• W2807075107 hasAuthorship W2807075107A5082566756 @default.
• W2807075107 hasAuthorship W2807075107A5086838488 @default.
• W2807075107 hasAuthorship W2807075107A5091592799 @default.
• W2807075107 hasBestOaLocation W28070751071 @default.
• W2807075107 hasConcept C121608353 @default.
• W2807075107 hasConcept C126322002 @default.
• W2807075107 hasConcept C143998085 @default.
• W2807075107 hasConcept C207103383 @default.
• W2807075107 hasConcept C23589133 @default.
• W2807075107 hasConcept C2776694085 @default.
• W2807075107 hasConcept C2778336483 @default.
• W2807075107 hasConcept C2780835546 @default.
• W2807075107 hasConcept C2781190966 @default.
• W2807075107 hasConcept C2781413609 @default.
• W2807075107 hasConcept C44249647 @default.
• W2807075107 hasConcept C50382708 @default.
• W2807075107 hasConcept C530470458 @default.
• W2807075107 hasConcept C71924100 @default.
• W2807075107 hasConcept C84606932 @default.
• W2807075107 hasConceptScore W2807075107C121608353 @default.
• W2807075107 hasConceptScore W2807075107C126322002 @default.
• W2807075107 hasConceptScore W2807075107C143998085 @default.
• W2807075107 hasConceptScore W2807075107C207103383 @default.
• W2807075107 hasConceptScore W2807075107C23589133 @default.
• W2807075107 hasConceptScore W2807075107C2776694085 @default.
• W2807075107 hasConceptScore W2807075107C2778336483 @default.
• W2807075107 hasConceptScore W2807075107C2780835546 @default.

• next