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• W2807079061 endingPage "e0197713" @default.
• W2807079061 startingPage "e0197713" @default.
• W2807079061 abstract "Background & aims Breastfeeding is beneficial for mothers and infants. Underlying mechanisms and biochemical mediators thus need to be investigated to develop and support improved infant nutrition practices promoting the child health. We analysed the relation between maternal breast milk composition and infant metabolism. Methods 196 pairs of mothers and infants from a European research project (PreventCD) were studied. Maternal milk samples collected at month 1 and month 4 after birth were analysed for macronutrient classes, hormone, and fatty acid (FA) content. Phospholipids, acylcarnitines, and amino acids were measured in serum samples of 4-month old infants. Associations between milk components and infant metabolites were analysed with spearman correlation and linear mixed effect models (LME). P-values were corrected for multiple testing (PLME). Results Month 1 milk protein content was strongly associated with infant serum lyso-phosphatidylcholine (LPC) 14:0 (PLME = 0.009). Month 1 milk insulin was associated to infant acetylcarnitine (PLME = 0.01). There were no associations between milk protein content and serum amino acids and milk total fat content and serum polar lipids. Middle- and odd-chain FA% in breast milk at both ages were significantly related to serum LPC and sphingomyelins (SM) species in infant serum (all PLME<0.05), while FA% 20:5n-3 and 22:6n-3 percentages were significantly associated to serum LPC 22:6 (PLME = 1.91×10−4/7.93×10−5) in milk only at month 4. Other polyunsaturated fatty acids and hormones in milk showed only weak associations with infant serum metabolites. Conclusions Infant serum LPC are influenced by breast milk FA composition and, intriguingly, milk protein content in early but not late lactation. LPC 14:0, previously found positively associated with obesity risk, was the serum metabolite which was the most strongly associated to milk protein content. Thus, LPC 14:0 might be a key metabolite not only reflecting milk protein intake in infants, but also relating high protein content in milk or infant formula to childhood obesity risk." @default.
• W2807079061 created "2018-06-13" @default.
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• W2807079061 date "2018-06-01" @default.
• W2807079061 modified "2023-10-17" @default.
• W2807079061 title "The impact of human breast milk components on the infant metabolism" @default.
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• W2807079061 doi "https://doi.org/10.1371/journal.pone.0197713" @default.
• W2807079061 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5983411" @default.
• W2807079061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29856767" @default.
• W2807079061 hasPublicationYear "2018" @default.
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