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• W2807113487 abstract "Abstract The aim of the study was to investigate the effect of 2 nd -line pazopanib on the different CTCs subpopulations in SCLC patients and evaluate the clinical relevance of their changes. Different CTCs subpopulations were evaluated before pazopanib initiation (n = 56 patients), after one-cycle (n = 35) and on disease progression (n = 45) by CellSearch and double immunofluorescence using anti-CKs and anti-Ki67, anti-M30 or anti-Vimentin antibodies. Before treatment, CTCs were detected in 50% of patients by CellSearch whereas 53.4%, 15.5% and 74.1% patients had CK + /Ki67 + , CK + /M30 + and CK + /Vim + CTCs, respectively. One pazopanib cycle significantly decreased the number of CTCs as detected by CellSearch ( p = 0.043) as well as the number of CK + /Ki67 + ( p < 0.001), CK + /M30 + ( p = 0 . 015) and CK + /Vim + ( p < 0 . 001) cells. On disease progression, both the incidence and CTC numbers were significantly increased (CellSearch, p = 0.027; CK + /Ki67 + , p < 0.001; CK +/ M30 + , p = 0.001 and CK + /Vim + , p < 0 . 001) . In multivariate analysis, the detection of CK + /Vim + CTCs after one treatment cycle (HR: 7.9, 95% CI: 2.9–21.8; p < 0.001) and CTCs number on disease progression, as assessed by CellSearch, (HR: 2.0, 95% CI: 1.0–6.0; p = 0.005) were emerged as independent factors associated with decreased OS. In conclusion, pazopanib can eliminate different CTC subpopulations in patients with relapsed SCLC. The analysis of CTCs could be used as a dynamic biomarker of treatment efficacy." @default.
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• W2807113487 date "2018-02-02" @default.
• W2807113487 modified "2023-10-13" @default.
• W2807113487 title "Dynamic changes of phenotypically different circulating tumor cells sub-populations in patients with recurrent/refractory small cell lung cancer treated with pazopanib" @default.
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• W2807113487 doi "https://doi.org/10.1038/s41598-018-20502-1" @default.
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