Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807129591> ?p ?o ?g. }
- W2807129591 endingPage "2567" @default.
- W2807129591 startingPage "2552" @default.
- W2807129591 abstract "Summary The use of toxin to attack neighbours and immunity proteins to protect against toxin has been observed in bacterial conflicts, including kin discrimination. Here, we report a novel nuclease‐toxin and its immunity protein function in the colony‐merger incompatibility, a kind of bacterial kin discrimination, in Myxococcus xanthus DK1622. The MXAN_0049 gene was determined to be a genetic determinant for colony‐merger incompatibility, and the incompatibility could be eliminated by deletion of the upstream co‐transcribed MXAN_0050 gene. We demonstrated that the MXAN_0050 protein was a nuclease, and MXAN_0049 protein was able to bind to MXAN_0050 to block nuclease activity in vitro . Expression of MXAN_0050 in Escherichia coli inhibited cellular growth, and the inhibition effect could be recovered by co‐expression of MXAN_0049. We found that deletion of the PAAR‐encoding gene ( MXAN_0044 ) or the type VI secretion system led to the colony‐merger and co‐existence with the Δ MXAN_0049 mutant, suggesting that they were associated with colony‐merger incompatibility. Homologues of the nuclease‐toxin and cognate immunity pair are widely distributed in bacteria. We propose a simplified model to explain the kin discrimination mechanism mediated by the nuclease‐toxin and immunity protein.© 2018 Society for Applied Microbiology and John Wiley & Sons Ltd" @default.
- W2807129591 created "2018-06-13" @default.
- W2807129591 creator A5007100954 @default.
- W2807129591 creator A5050524531 @default.
- W2807129591 creator A5061634319 @default.
- W2807129591 creator A5081873395 @default.
- W2807129591 creator A5087428956 @default.
- W2807129591 creator A5089611409 @default.
- W2807129591 creator A5090538142 @default.
- W2807129591 creator A5091459500 @default.
- W2807129591 date "2018-07-01" @default.
- W2807129591 modified "2023-10-16" @default.
- W2807129591 title "A nuclease‐toxin and immunity system for kin discrimination in<i>Myxococcus xanthus</i>" @default.
- W2807129591 cites W1563474996 @default.
- W2807129591 cites W1952228151 @default.
- W2807129591 cites W1966688540 @default.
- W2807129591 cites W1967663492 @default.
- W2807129591 cites W1969658400 @default.
- W2807129591 cites W1972038449 @default.
- W2807129591 cites W1974927036 @default.
- W2807129591 cites W1976555793 @default.
- W2807129591 cites W1982985744 @default.
- W2807129591 cites W1983455597 @default.
- W2807129591 cites W1987134040 @default.
- W2807129591 cites W2002643153 @default.
- W2807129591 cites W2019140963 @default.
- W2807129591 cites W2019551237 @default.
- W2807129591 cites W2021636461 @default.
- W2807129591 cites W2025882094 @default.
- W2807129591 cites W2027150254 @default.
- W2807129591 cites W2040539560 @default.
- W2807129591 cites W2041309451 @default.
- W2807129591 cites W2056086701 @default.
- W2807129591 cites W2062757530 @default.
- W2807129591 cites W2066034383 @default.
- W2807129591 cites W2085360155 @default.
- W2807129591 cites W2088177994 @default.
- W2807129591 cites W2089261995 @default.
- W2807129591 cites W2089835422 @default.
- W2807129591 cites W2097623920 @default.
- W2807129591 cites W2102245393 @default.
- W2807129591 cites W2103906225 @default.
- W2807129591 cites W2107142921 @default.
- W2807129591 cites W2108920131 @default.
- W2807129591 cites W2109834023 @default.
- W2807129591 cites W2112405266 @default.
- W2807129591 cites W2121534039 @default.
- W2807129591 cites W2123035125 @default.
- W2807129591 cites W2126677834 @default.
- W2807129591 cites W2128007785 @default.
- W2807129591 cites W2131934935 @default.
- W2807129591 cites W2136910774 @default.
- W2807129591 cites W2137087452 @default.
- W2807129591 cites W2140247702 @default.
- W2807129591 cites W2141401164 @default.
- W2807129591 cites W2146341019 @default.
- W2807129591 cites W2152627116 @default.
- W2807129591 cites W2153544371 @default.
- W2807129591 cites W2154978995 @default.
- W2807129591 cites W2158266834 @default.
- W2807129591 cites W2160378127 @default.
- W2807129591 cites W2161151688 @default.
- W2807129591 cites W2165043209 @default.
- W2807129591 cites W2166251364 @default.
- W2807129591 cites W2171047976 @default.
- W2807129591 cites W2173732482 @default.
- W2807129591 cites W2213170528 @default.
- W2807129591 cites W2224056471 @default.
- W2807129591 cites W2277281665 @default.
- W2807129591 cites W2313783534 @default.
- W2807129591 cites W2326852246 @default.
- W2807129591 cites W2469573812 @default.
- W2807129591 cites W2521409077 @default.
- W2807129591 cites W2567063872 @default.
- W2807129591 cites W2587248289 @default.
- W2807129591 cites W4237594258 @default.
- W2807129591 cites W4247100158 @default.
- W2807129591 cites W4247927165 @default.
- W2807129591 cites W4256558498 @default.
- W2807129591 doi "https://doi.org/10.1111/1462-2920.14282" @default.
- W2807129591 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29806725" @default.
- W2807129591 hasPublicationYear "2018" @default.
- W2807129591 type Work @default.
- W2807129591 sameAs 2807129591 @default.
- W2807129591 citedByCount "19" @default.
- W2807129591 countsByYear W28071295912019 @default.
- W2807129591 countsByYear W28071295912020 @default.
- W2807129591 countsByYear W28071295912021 @default.
- W2807129591 countsByYear W28071295912022 @default.
- W2807129591 countsByYear W28071295912023 @default.
- W2807129591 crossrefType "journal-article" @default.
- W2807129591 hasAuthorship W2807129591A5007100954 @default.
- W2807129591 hasAuthorship W2807129591A5050524531 @default.
- W2807129591 hasAuthorship W2807129591A5061634319 @default.
- W2807129591 hasAuthorship W2807129591A5081873395 @default.
- W2807129591 hasAuthorship W2807129591A5087428956 @default.
- W2807129591 hasAuthorship W2807129591A5089611409 @default.
- W2807129591 hasAuthorship W2807129591A5090538142 @default.