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- W2807134839 abstract "Septins belong to a family of GTP‐binding proteins that bind to phosphoinositides (PIs) by a polybasic domain (PB1). We reported that the deletion of PB1 in septin 9 markedly reduced, its binding to PIs and its assembly. Here, using homology modelling, we reveal the presence of another polybasic domain (PB2) conserved among the different human septins. PB1 and PB2 from two distinct molecules form an extended basic cluster in the NC interface of the filament. Importantly binding of septin 9 to PIs through PB1 and PB2 is required for recruitment of microtubules to Golgi stacks and their assembly. Knockdown of septin 9 recapitulates these effects and affects nucleus/centrosomal positioning and protein secretion. Thus septin 9 could be considered as a crucial regulator of events require for membrane trafficking and organelle morphology." @default.
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- W2807134839 date "2018-01-01" @default.
- W2807134839 modified "2023-09-23" @default.
- W2807134839 title "Identification of a Second Conserved Polybasic Domain in Septin 9 Involved in MicrotubuleeDependent Golgi Assembly" @default.
- W2807134839 doi "https://doi.org/10.2139/ssrn.3155655" @default.
- W2807134839 hasPublicationYear "2018" @default.
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