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• W2807152078 abstract "Since human Nucleoside Transporters (hNTs) were identified by their activity as transport systems, extensive work has been done to fully characterize them at the molecular and physiological level. Many efforts have been addressed to the identification of their selectivity for natural substrates and nucleoside analogs used to treat several diseases. hNTs belong to two different gene families, SLC28 and SLC29, encoding human Concentrative Nucleoside Transporters (hCNTs) and human Equilibrative Nucleoside Transporters (hENTs), respectively. hCNTs and hENTs are integral membrane proteins, albeit structurally unrelated. Both families share common features as substrate selectivity and often tissue localization. This apparent biological redundancy may anticipate some different roles for hCNTs and hENTs in cell physiology. Thus, hENTs may have a major role in maintaining nucleoside homeostasis, whereas hCNTs could contribute to nucleoside sensing and signal transduction. In this sense, the ascription of hCNT1 to a transceptor reinforces this hypothesis. Moreover, some evidences could suggest a putative role of hCNT2 and hCNT3 as transceptors. The interacting proteins identified for hCNT2 suggest a link to energy metabolism. Moreover, the ability of hCNT2 and hCNT3 to transport adenosine links both proteins to purinergic signaling. On the other hand, the broad selectivity transporters hENTs have a crucial role in salvage pathways and purinergic signaling by means of nucleoside pools regulation. In particular, the two new hENT2 isoforms recently described together with hENT2 seem to be key elements controlling nucleoside and nucleotide pools for DNA synthesis. This review focuses on all these NTs functions beyond their mere translocation ability." @default.
• W2807152078 created "2018-06-13" @default.
• W2807152078 creator A5026914019 @default.
• W2807152078 creator A5067664369 @default.
• W2807152078 date "2018-06-06" @default.
• W2807152078 modified "2023-10-16" @default.
• W2807152078 title "Emerging Roles of Nucleoside Transporters" @default.
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• W2807152078 cites W1500281827 @default.
• W2807152078 cites W1504019646 @default.
• W2807152078 cites W1520083288 @default.
• W2807152078 cites W1521608980 @default.
• W2807152078 cites W1581668977 @default.
• W2807152078 cites W1831079403 @default.
• W2807152078 cites W1963898985 @default.
• W2807152078 cites W1966332025 @default.
• W2807152078 cites W1966752296 @default.
• W2807152078 cites W1969211295 @default.
• W2807152078 cites W1969984411 @default.
• W2807152078 cites W1970037432 @default.
• W2807152078 cites W1971118371 @default.
• W2807152078 cites W1973399786 @default.
• W2807152078 cites W1975921630 @default.
• W2807152078 cites W1981040381 @default.
• W2807152078 cites W1981608445 @default.
• W2807152078 cites W1987212917 @default.
• W2807152078 cites W2001209561 @default.
• W2807152078 cites W2009562654 @default.
• W2807152078 cites W2015707426 @default.
• W2807152078 cites W2016190772 @default.
• W2807152078 cites W2018189509 @default.
• W2807152078 cites W2022844399 @default.
• W2807152078 cites W2034326442 @default.
• W2807152078 cites W2035418610 @default.
• W2807152078 cites W2042464260 @default.
• W2807152078 cites W2048124287 @default.
• W2807152078 cites W2055366578 @default.
• W2807152078 cites W2055726464 @default.
• W2807152078 cites W2061147784 @default.
• W2807152078 cites W2062929559 @default.
• W2807152078 cites W2063867263 @default.
• W2807152078 cites W2067693268 @default.
• W2807152078 cites W2069161912 @default.
• W2807152078 cites W2073792842 @default.
• W2807152078 cites W2073983610 @default.
• W2807152078 cites W2077516532 @default.
• W2807152078 cites W2077791002 @default.
• W2807152078 cites W2079108655 @default.
• W2807152078 cites W2083573587 @default.
• W2807152078 cites W2085151179 @default.
• W2807152078 cites W2096719845 @default.
• W2807152078 cites W2099541055 @default.
• W2807152078 cites W2101017561 @default.
• W2807152078 cites W2106149278 @default.
• W2807152078 cites W2109589477 @default.
• W2807152078 cites W2117535436 @default.
• W2807152078 cites W2132137584 @default.
• W2807152078 cites W2133579393 @default.
• W2807152078 cites W2134196477 @default.
• W2807152078 cites W2140006576 @default.
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• W2807152078 cites W2146470521 @default.
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• W2807152078 cites W2152271995 @default.
• W2807152078 cites W2153857382 @default.
• W2807152078 cites W2163840565 @default.
• W2807152078 cites W2166721976 @default.
• W2807152078 cites W2171627722 @default.
• W2807152078 cites W2194342134 @default.
• W2807152078 cites W2286532017 @default.
• W2807152078 cites W2291952397 @default.
• W2807152078 cites W2306118330 @default.
• W2807152078 cites W2334274059 @default.
• W2807152078 cites W2343100729 @default.
• W2807152078 cites W2410658132 @default.
• W2807152078 cites W2418367241 @default.
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• W2807152078 cites W2577132550 @default.
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• W2807152078 doi "https://doi.org/10.3389/fphar.2018.00606" @default.
• W2807152078 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5997781" @default.
• W2807152078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29928232" @default.
• W2807152078 hasPublicationYear "2018" @default.
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