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- W2807158105 abstract "Seven new α,β-diphenyl-γ-butyrolactones (1–7), three new lignans (8–10), five new neolignans (11–15), two new 1,3-biphenylpropanoids (16 and 17), and a new flavonol galactoside-lignan ester (18), together with 43 known compounds (19–61), were isolated from the twigs of Cinnamomum cassia. Their structures were elucidated by spectroscopic data analysis as well as chemical methods. The α,β-diphenyl-γ-butyrolactones are a class of unique natural compounds that have only been isolated from C. cassia. Compounds 11 and 12 are rare examples of neolignans possessing a 1,2-dioxetane moiety. Compound 13 is a new oxyneolignan possessing a unique C-9–O–C-9′ linkage between the benzopyran and cinnamyl alcohol moieties. Compound 15 is the first example of a natural neolignan possessing a 2-styryl-3-phenyltetrahydrofuran skeleton. The isolated compounds were evaluated for their neuroprotective activities against tunicamycin-induced cytotoxicity in SH-SY5Y cells. Compounds 3, 5, 10, 11, 12, 20, 36, and 56 showed statistically significant neuroprotective activity with EC50 values ranging between 21 and 75 μM." @default.
- W2807158105 created "2018-06-13" @default.
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- W2807158105 date "2018-06-08" @default.
- W2807158105 modified "2023-10-14" @default.
- W2807158105 title "Phenolic Constituents Isolated from the Twigs of <i>Cinnamomum cassia</i> and Their Potential Neuroprotective Effects" @default.
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- W2807158105 doi "https://doi.org/10.1021/acs.jnatprod.7b00924" @default.
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