Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807161463> ?p ?o ?g. }
- W2807161463 endingPage "18" @default.
- W2807161463 startingPage "1" @default.
- W2807161463 abstract "Infections with Pseudomonas aeruginosa have become a real concern in hospital-acquired infections, especially in critically ill and immunocompromised patients. The major problem leading to high mortality lies in the appearance of drug-resistant strains. Therefore, a vast number of approaches to develop novel anti-infectives is currently pursued. Diverse strategies range from killing (new antibiotics) to disarming (antivirulence) the pathogen. In this review, selected aspects of P. aeruginosa antimicrobial resistance and infection management will be addressed. Many studies have been performed to evaluate the risk factors for resistance and the potential consequences on mortality and attributable mortality. The review also looks at the mechanisms associated with resistance - P. aeruginosa is a pathogen presenting a large genome, and it can develop a large number of factors associated with antibiotic resistance involving almost all classes of antibiotics. Clinical approaches to patients with bacteremia, ventilator-associated pneumonia, urinary tract infections and skin soft tissue infections are discussed. Antibiotic combinations are reviewed as well as an analysis of pharmacokinetic and pharmacodynamic parameters to optimize P. aeruginosa treatment. Limitations of current therapies, the potential for alternative drugs and new therapeutic options are also discussed." @default.
- W2807161463 created "2018-06-13" @default.
- W2807161463 creator A5024094072 @default.
- W2807161463 creator A5024299541 @default.
- W2807161463 creator A5033405993 @default.
- W2807161463 creator A5039694085 @default.
- W2807161463 creator A5058310698 @default.
- W2807161463 date "2018-05-29" @default.
- W2807161463 modified "2023-10-18" @default.
- W2807161463 title "How to manage Pseudomonas aeruginosa infections" @default.
- W2807161463 cites W1251482461 @default.
- W2807161463 cites W137943344 @default.
- W2807161463 cites W1490277221 @default.
- W2807161463 cites W1675696738 @default.
- W2807161463 cites W1751253656 @default.
- W2807161463 cites W1796585208 @default.
- W2807161463 cites W1908329802 @default.
- W2807161463 cites W1917162549 @default.
- W2807161463 cites W1918005905 @default.
- W2807161463 cites W1963802535 @default.
- W2807161463 cites W1963880769 @default.
- W2807161463 cites W1964915993 @default.
- W2807161463 cites W1965672390 @default.
- W2807161463 cites W1969500929 @default.
- W2807161463 cites W1970223397 @default.
- W2807161463 cites W1972650861 @default.
- W2807161463 cites W1974319298 @default.
- W2807161463 cites W1975305392 @default.
- W2807161463 cites W1980567277 @default.
- W2807161463 cites W1983111400 @default.
- W2807161463 cites W1984245130 @default.
- W2807161463 cites W1989886020 @default.
- W2807161463 cites W1993186621 @default.
- W2807161463 cites W1995426359 @default.
- W2807161463 cites W2002773042 @default.
- W2807161463 cites W2005758646 @default.
- W2807161463 cites W2009045396 @default.
- W2807161463 cites W2012545798 @default.
- W2807161463 cites W2015372428 @default.
- W2807161463 cites W2018229558 @default.
- W2807161463 cites W2020137961 @default.
- W2807161463 cites W2024211260 @default.
- W2807161463 cites W2024578173 @default.
- W2807161463 cites W2029168882 @default.
- W2807161463 cites W2033771579 @default.
- W2807161463 cites W2034428052 @default.
- W2807161463 cites W2035680987 @default.
- W2807161463 cites W2039148583 @default.
- W2807161463 cites W2043944432 @default.
- W2807161463 cites W2045419501 @default.
- W2807161463 cites W2048390434 @default.
- W2807161463 cites W2056073249 @default.
- W2807161463 cites W2060495363 @default.
- W2807161463 cites W2062886433 @default.
- W2807161463 cites W2067981587 @default.
- W2807161463 cites W2075287054 @default.
- W2807161463 cites W2081960029 @default.
- W2807161463 cites W2083151701 @default.
- W2807161463 cites W2085499319 @default.
- W2807161463 cites W2091433599 @default.
- W2807161463 cites W2096497624 @default.
- W2807161463 cites W2097293600 @default.
- W2807161463 cites W2097894986 @default.
- W2807161463 cites W2098057508 @default.
- W2807161463 cites W2101416655 @default.
- W2807161463 cites W2103752133 @default.
- W2807161463 cites W2105868980 @default.
- W2807161463 cites W2110143006 @default.
- W2807161463 cites W2110424949 @default.
- W2807161463 cites W2115445096 @default.
- W2807161463 cites W2115562145 @default.
- W2807161463 cites W2116244618 @default.
- W2807161463 cites W2116245384 @default.
- W2807161463 cites W2116814997 @default.
- W2807161463 cites W2117064229 @default.
- W2807161463 cites W2119724838 @default.
- W2807161463 cites W2124226097 @default.
- W2807161463 cites W2127653962 @default.
- W2807161463 cites W2128322373 @default.
- W2807161463 cites W2131256712 @default.
- W2807161463 cites W2132481695 @default.
- W2807161463 cites W2133444948 @default.
- W2807161463 cites W2133979383 @default.
- W2807161463 cites W2134087618 @default.
- W2807161463 cites W2134352676 @default.
- W2807161463 cites W2134789996 @default.
- W2807161463 cites W2134999596 @default.
- W2807161463 cites W2136609531 @default.
- W2807161463 cites W2137081432 @default.
- W2807161463 cites W2137998290 @default.
- W2807161463 cites W2139382674 @default.
- W2807161463 cites W2141027223 @default.
- W2807161463 cites W2143172705 @default.
- W2807161463 cites W2149088130 @default.
- W2807161463 cites W2149410208 @default.
- W2807161463 cites W2151496242 @default.
- W2807161463 cites W2152116638 @default.
- W2807161463 cites W2152553897 @default.