FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807163399> ?p ?o ?g. }

• W2807163399 endingPage "e132" @default.
• W2807163399 startingPage "e132" @default.
• W2807163399 abstract "Objective: At least 10% of pheochromocytoma and sympathetic paraganglioma (PPGL) are malignant, yet there is no specific biomarker of malignancy. Societies guidelines sugget the use of 3 Methoxytyramines (3MTT) for the diagnosis of malignancy, however few studies evaluated 24H-urinary 3MTT as a predictor of malignancy. The aim of this study was to evaluate the sensitivity/specificity of 24H-Urinary 3MTT for the diagnosis of malignant PPGLDesign and method: We conducted a retrospective study of electronic registers of Hypertension excellence center of Georges Pompidou hospital, from 2012 to 2015 to identify patients who completed PPGL-workup: Measurement of 24H-Urinary metanephrines/Normetanephrines(MTN/NMT) and 24H-Ur 3MTT by LCMS, Imaging exams to confirm/exclude PPGL, histopathological diagnosis of PPGL after surgery. We excluded from our analysis patients without the diagnosis of PPGL, under medications interacting with MTN/NMT/3MTT secretion, or without 24H-Ur 3MTT determination Determination of 24H-Ur MTN/NMT/3MTT was made by LCMS method with validated protocol. We first analysed ROC parameters for 24h-Ur 3MTT, then those of 24H-Ur 3MTT to 24H-Ur creatinine ratio. Results: 47 patients were included in this study:8 malignant PPGL and 39 non malignant PPGL. ROC curve of sensitivity(1-specificity) of 24h-Ur 3MTT for the diagnosis of PPGL malignancy showed an area under curve(AUC) of 0.671[95%CI 0.519–0.801]: The optimal criterion of the curve corresponded to a value of 24h-Ur 3MTT of 4.67 μmol/24 h and showed a specificity of 82.05% and sensitivity of 62.5% for malignancy diagnosis. A value > 12 μmol/24 h of 24h-Ur 3MTT offered 100% specificity with 37.5% of sensitivity ROC curve of sensitivity(1-specificity) of 24h-Ur 3MTT/24h-Ur Creatininuria for the diagnosis of PPGL malignancy showed an AUC of 0.774 [95%CI 0.629–0.883]: The optimal criterion of the curve was 1.25 μmol/mmol with a specificity of 94.87% and a sensitivity of 50% for the diagnosis of malignancy. A value of 24h-Ur 3MTT/Cr > 1.73 μmol/mmol offered 100% specificity with 25% sensitivity. Conclusions: These data sugget that 24h-Urinary 3MTT measured by LCMS and 24h-Ur 3MTT to creatinine ratio could be used as valuable biomarkers for the diagnosis of malignant PPGL. Values superior to 4.67 μmol/l and 1.25 μmol/mmol respectively offered the best compromise between high specificities and average sensitivities." @default.
• W2807163399 created "2018-06-13" @default.
• W2807163399 creator A5000631329 @default.
• W2807163399 creator A5028088035 @default.
• W2807163399 creator A5044532816 @default.
• W2807163399 creator A5048788958 @default.
• W2807163399 creator A5059403921 @default.
• W2807163399 creator A5077098386 @default.
• W2807163399 creator A5083199308 @default.
• W2807163399 creator A5087811288 @default.
• W2807163399 creator A5088372894 @default.
• W2807163399 date "2018-06-01" @default.
• W2807163399 modified "2023-10-01" @default.
• W2807163399 title "SENSITIVITY AND SPECIFICITY OF 24 HOURS URINARY 3-METHOXYTYRAMINES IN THE DIAGNOSIS OF MALIGNANT PHEOCHROMOCYTOMA AND PARAGANGLIOMA" @default.
• W2807163399 doi "https://doi.org/10.1097/01.hjh.0000539342.92258.fd" @default.
• W2807163399 hasPublicationYear "2018" @default.
• W2807163399 type Work @default.
• W2807163399 sameAs 2807163399 @default.
• W2807163399 citedByCount "0" @default.
• W2807163399 crossrefType "journal-article" @default.
• W2807163399 hasAuthorship W2807163399A5000631329 @default.
• W2807163399 hasAuthorship W2807163399A5028088035 @default.
• W2807163399 hasAuthorship W2807163399A5044532816 @default.
• W2807163399 hasAuthorship W2807163399A5048788958 @default.
• W2807163399 hasAuthorship W2807163399A5059403921 @default.
• W2807163399 hasAuthorship W2807163399A5077098386 @default.
• W2807163399 hasAuthorship W2807163399A5083199308 @default.
• W2807163399 hasAuthorship W2807163399A5087811288 @default.
• W2807163399 hasAuthorship W2807163399A5088372894 @default.
• W2807163399 hasConcept C126322002 @default.
• W2807163399 hasConcept C126838900 @default.
• W2807163399 hasConcept C126894567 @default.
• W2807163399 hasConcept C134018914 @default.
• W2807163399 hasConcept C2776734335 @default.
• W2807163399 hasConcept C2779161898 @default.
• W2807163399 hasConcept C2779399171 @default.
• W2807163399 hasConcept C2779512018 @default.
• W2807163399 hasConcept C2780306776 @default.
• W2807163399 hasConcept C71924100 @default.
• W2807163399 hasConcept C76318530 @default.
• W2807163399 hasConcept C77411442 @default.
• W2807163399 hasConcept C90924648 @default.
• W2807163399 hasConceptScore W2807163399C126322002 @default.
• W2807163399 hasConceptScore W2807163399C126838900 @default.
• W2807163399 hasConceptScore W2807163399C126894567 @default.
• W2807163399 hasConceptScore W2807163399C134018914 @default.
• W2807163399 hasConceptScore W2807163399C2776734335 @default.
• W2807163399 hasConceptScore W2807163399C2779161898 @default.
• W2807163399 hasConceptScore W2807163399C2779399171 @default.
• W2807163399 hasConceptScore W2807163399C2779512018 @default.
• W2807163399 hasConceptScore W2807163399C2780306776 @default.
• W2807163399 hasConceptScore W2807163399C71924100 @default.
• W2807163399 hasConceptScore W2807163399C76318530 @default.
• W2807163399 hasConceptScore W2807163399C77411442 @default.
• W2807163399 hasConceptScore W2807163399C90924648 @default.
• W2807163399 hasIssue "Supplement 1" @default.
• W2807163399 hasLocation W28071633991 @default.
• W2807163399 hasOpenAccess W2807163399 @default.
• W2807163399 hasPrimaryLocation W28071633991 @default.
• W2807163399 hasRelatedWork W1420833956 @default.
• W2807163399 hasRelatedWork W1924230165 @default.
• W2807163399 hasRelatedWork W2043583077 @default.
• W2807163399 hasRelatedWork W2169679194 @default.
• W2807163399 hasRelatedWork W2898765265 @default.
• W2807163399 hasRelatedWork W3172341590 @default.
• W2807163399 hasRelatedWork W4210772647 @default.
• W2807163399 hasRelatedWork W4212990954 @default.
• W2807163399 hasRelatedWork W4235656803 @default.
• W2807163399 hasRelatedWork W4245436028 @default.
• W2807163399 hasVolume "36" @default.
• W2807163399 isParatext "false" @default.
• W2807163399 isRetracted "false" @default.
• W2807163399 magId "2807163399" @default.
• W2807163399 workType "article" @default.