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• W2807178337 abstract "Background . MicroRNAs (miRs) have been implicated in the development and progression of osteosarcoma. Here, we aimed to illustrate the important role of miR-92a on the regulation of OS development which may help to establish a novel strategy for OS diagnosis and treatment. Materials and Methods . Cell viability was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell cycle and apoptosis were assessed by flow cytometry with PI and PI/Annexin-V stain, respectively. The expression of proteins was examined by western blot. qPCR was used to detect the expression of RNA. Cell migration was assayed with transwell assay. Results . MiR-92a inhibited the proliferation and the migration of OS in vitro and reduced the volume of the tumour in vivo . Further, miR-92a enhanced cisplatin sensitivity of OS. MiR-92a directly targeted Notch1. Conclusion . Together, our results indicate that miR-92a inhibited cell growth, migration, and enhanced cisplatin sensitivity of OS cell by targeting Notch1." @default.
• W2807178337 created "2018-06-13" @default.
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• W2807178337 date "2018-06-07" @default.
• W2807178337 modified "2023-10-15" @default.
• W2807178337 title "MiR-92a Inhibits the Progress of Osteosarcoma Cells and Increases the Cisplatin Sensitivity by Targeting Notch1" @default.
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• W2807178337 doi "https://doi.org/10.1155/2018/9870693" @default.
• W2807178337 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6011149" @default.
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