FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807186631> ?p ?o ?g. }

• W2807186631 endingPage "715" @default.
• W2807186631 startingPage "705" @default.
• W2807186631 abstract "Low dopamine D2/3 receptor availability in the nucleus accumbens shell is associated with highly impulsive behavior in rats as measured by premature responses in a cued attentional task. However, it is unclear whether dopamine D2/3 receptor availability in the nucleus accumbens is equally linked to intolerance for delayed rewards, a related form of impulsivity.We investigated the relationship between D2/3 receptor availability in the nucleus accumbens and impulsivity in a delay-discounting task where animals must choose between immediate, small-magnitude rewards and delayed, larger-magnitude rewards. Corticostriatal D2/3 receptor availability was measured in rats stratified for high and low impulsivity using in vivo [18F]fallypride positron emission tomography and ex vivo [3H]raclopride autoradiography. Resting-state functional connectivity in limbic corticostriatal networks was also assessed using fMRI.Delay-discounting task impulsivity was inversely related to D2/3 receptor availability in the nucleus accumbens core but not the dorsal striatum, with higher D2/3 binding in the nucleus accumbens shell of high-impulsive rats compared with low-impulsive rats. D2/3 receptor availability was associated with stronger connectivity between the cingulate cortex and hippocampus of high- vs low-impulsive rats.We conclude that delay-discounting task impulsivity is associated with low D2/3 receptor binding in the nucleus accumbens core. Thus, two related forms of waiting impulsivity-premature responding and delay intolerance in a delay-of-reward task-implicate an involvement of D2/3 receptor availability in the nucleus accumbens shell and core, respectively. This dissociation may be causal or consequential to enhanced functional connectivity of limbic brain circuitry and hold relevance for attention-deficit/hyperactivity disorder, drug addiction, and other psychiatric disorders." @default.
• W2807186631 created "2018-06-13" @default.
• W2807186631 creator A5035188600 @default.
• W2807186631 creator A5036397323 @default.
• W2807186631 creator A5040901375 @default.
• W2807186631 creator A5047056425 @default.
• W2807186631 creator A5060460457 @default.
• W2807186631 creator A5075499883 @default.
• W2807186631 creator A5090410744 @default.
• W2807186631 date "2018-03-15" @default.
• W2807186631 modified "2023-09-26" @default.
• W2807186631 title "Ventral Striatal D2/3 Receptor Availability Is Associated with Impulsive Choice Behavior As Well As Limbic Corticostriatal Connectivity" @default.
• W2807186631 cites W1561198779 @default.
• W2807186631 cites W1973466311 @default.
• W2807186631 cites W1975014122 @default.
• W2807186631 cites W1976114527 @default.
• W2807186631 cites W1982834603 @default.
• W2807186631 cites W1983332126 @default.
• W2807186631 cites W1989816896 @default.
• W2807186631 cites W1990134753 @default.
• W2807186631 cites W1992615559 @default.
• W2807186631 cites W1992831823 @default.
• W2807186631 cites W2004470044 @default.
• W2807186631 cites W2011913628 @default.
• W2807186631 cites W2015402194 @default.
• W2807186631 cites W2016521885 @default.
• W2807186631 cites W2021782736 @default.
• W2807186631 cites W2024066498 @default.
• W2807186631 cites W2029087047 @default.
• W2807186631 cites W2029682831 @default.
• W2807186631 cites W2042824095 @default.
• W2807186631 cites W2043185143 @default.
• W2807186631 cites W2043729058 @default.
• W2807186631 cites W2047679742 @default.
• W2807186631 cites W2054050985 @default.
• W2807186631 cites W2054111217 @default.
• W2807186631 cites W2060946807 @default.
• W2807186631 cites W2062879497 @default.
• W2807186631 cites W2064671909 @default.
• W2807186631 cites W2069261271 @default.
• W2807186631 cites W2071411087 @default.
• W2807186631 cites W2072626594 @default.
• W2807186631 cites W2076158082 @default.
• W2807186631 cites W2079450984 @default.
• W2807186631 cites W2079598508 @default.
• W2807186631 cites W2081378522 @default.
• W2807186631 cites W2082078342 @default.
• W2807186631 cites W2083484236 @default.
• W2807186631 cites W2084824179 @default.
• W2807186631 cites W2091741867 @default.
• W2807186631 cites W2095574998 @default.
• W2807186631 cites W2109111086 @default.
• W2807186631 cites W2114523864 @default.
• W2807186631 cites W2115919116 @default.
• W2807186631 cites W2116128159 @default.
• W2807186631 cites W2120534695 @default.
• W2807186631 cites W2120911948 @default.
• W2807186631 cites W2121190453 @default.
• W2807186631 cites W2125079958 @default.
• W2807186631 cites W2126342361 @default.
• W2807186631 cites W2136906168 @default.
• W2807186631 cites W2138204170 @default.
• W2807186631 cites W2138273718 @default.
• W2807186631 cites W2159254339 @default.
• W2807186631 cites W2163274894 @default.
• W2807186631 cites W2163878597 @default.
• W2807186631 cites W2165159030 @default.
• W2807186631 cites W2170476476 @default.
• W2807186631 cites W2171080178 @default.
• W2807186631 cites W2277191980 @default.
• W2807186631 cites W2341712361 @default.
• W2807186631 cites W2472418055 @default.
• W2807186631 cites W2588692374 @default.
• W2807186631 cites W2590245649 @default.
• W2807186631 cites W2605653789 @default.
• W2807186631 cites W2610713520 @default.
• W2807186631 cites W2612129909 @default.
• W2807186631 doi "https://doi.org/10.1093/ijnp/pyy030" @default.
• W2807186631 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6030945" @default.
• W2807186631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29554302" @default.
• W2807186631 hasPublicationYear "2018" @default.
• W2807186631 type Work @default.
• W2807186631 sameAs 2807186631 @default.
• W2807186631 citedByCount "38" @default.
• W2807186631 countsByYear W28071866312018 @default.
• W2807186631 countsByYear W28071866312019 @default.
• W2807186631 countsByYear W28071866312020 @default.
• W2807186631 countsByYear W28071866312021 @default.
• W2807186631 countsByYear W28071866312022 @default.
• W2807186631 countsByYear W28071866312023 @default.
• W2807186631 crossrefType "journal-article" @default.
• W2807186631 hasAuthorship W2807186631A5035188600 @default.
• W2807186631 hasAuthorship W2807186631A5036397323 @default.
• W2807186631 hasAuthorship W2807186631A5040901375 @default.
• W2807186631 hasAuthorship W2807186631A5047056425 @default.
• W2807186631 hasAuthorship W2807186631A5060460457 @default.
• W2807186631 hasAuthorship W2807186631A5075499883 @default.
• W2807186631 hasAuthorship W2807186631A5090410744 @default.

• next