FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807187079> ?p ?o ?g. }

• W2807187079 endingPage "27513" @default.
• W2807187079 startingPage "27502" @default.
• W2807187079 abstract "// Fanny Foubert 1, 2 , Sébastien Gouard 1 , Catherine Saï-Maurel 1 , Michel Chérel 1, 3 , Alain Faivre-Chauvet 1, 4 , David M. Goldenberg 5, 6 , Jacques Barbet 1, 7 , Clément Bailly 1, 4 , Caroline Bodet-Milin 1, 3, 4 , Thomas Carlier 1, 4 , Françoise Kraeber-Bodéré 1, 3, 4 , Yann Touchefeu 1, 2, * and Eric Frampas 1, 8, * 1 CRCINA, INSERM, CNRS, Université d'Angers, Université de Nantes, Nantes, France 2 Hepato-Gastroenterology Department, Institut des Maladies de l’Appareil Digestif, University Hospital, Nantes, France 3 Nuclear Medicine Department, ICO René Gauducheau Cancer Center, Saint Herblain, France 4 Nuclear Medicine Department, University Hospital, Nantes, France 5 IBC Pharmaceuticals Inc., Morris Plains, New Jersey, USA 6 Immunomedics Inc., Morris Plains, New Jersey, USA 7 GIP ARRONAX, Saint-Herblain, Nantes, France 8 Radiology Department, University Hospital, Nantes, France * These authors have contributed equally to this work Correspondence to: Eric Frampas, email: Eric.frampas@chu-nantes.fr Keywords: carcinoembryonic antigen; colonic cancer; liver metastases; 18 FDG-PET; immuno-PET Received: December 06, 2017      Accepted: May 12, 2018      Published: June 08, 2018 ABSTRACT Purpose: The aim of this study was to compare the performances pretargeted immunoPET 68 Ga-PETimaging ( 68 Ga-pPET) with anti carcino-embryonic antigen (CEA) and anti-histamine-succinyl-glycine (HSG) recombinant humanized bispecific monoclonal antibody (TF2) and 68 Ga-labeled HSG peptide (IMP288) to conventional 18 FDG-PET in an orthotopic murine model of liver metastases of human colonic cancer. Methods: Hepatic tumor burden following intra-portal injection of luciferase-transfected LS174T cells in nude mice was confirmed using bioluminescence. One group of animals was injected intravenously with TF2 and with 68 Ga-IMP288 24 hours later (n=8). Another group received 18 FDG (n=8), and a third had both imaging modalities (n=7). PET acquisitions started 1 hour after injection of the radioconjugate. Biodistributions in tumors and normal tissues were assessed one hour after imaging. Results: Tumor/organ ratios were significantly higher with 68 Ga-pPET compared to 18 FDG-PET ( P <0.05) with both imaging and biodistribution data. 68 Ga-pPET sensitivity for tumor detection was 67% vs. 31% with 18 FDG PET ( P =0.049). For tumors less than 200 mg, the sensitivity was 44% with 68 Ga-pPET vs. 0% for 18 FDG PET ( P =0.031). A strong correlation was demonstrated between tumor uptakes measured on PET images and biodistribution analyses (r 2 =0.85). Conclusion: 68 Ga-pPET was more sensitive than 18 FDG-PET for the detection of human colonic liver metastases in an orthotopic murine xenograft model. Improved tumor/organ ratios support the use of pretargeting method for imaging and therapy of CEA-expressing tumors." @default.
• W2807187079 created "2018-06-13" @default.
• W2807187079 creator A5003890903 @default.
• W2807187079 creator A5004255429 @default.
• W2807187079 creator A5011758706 @default.
• W2807187079 creator A5027208541 @default.
• W2807187079 creator A5036627244 @default.
• W2807187079 creator A5041526466 @default.
• W2807187079 creator A5046980267 @default.
• W2807187079 creator A5055901701 @default.
• W2807187079 creator A5062263745 @default.
• W2807187079 creator A5064802518 @default.
• W2807187079 creator A5068656298 @default.
• W2807187079 creator A5077540798 @default.
• W2807187079 creator A5084534217 @default.
• W2807187079 date "2018-06-08" @default.
• W2807187079 modified "2023-10-14" @default.
• W2807187079 title "Sensitivity of pretargeted immunoPET using 68Ga-peptide to detect colonic carcinoma liver metastases in a murine xenograft model: Comparison with 18FDG PET-CT" @default.
• W2807187079 cites W119071926 @default.
• W2807187079 cites W1968592882 @default.
• W2807187079 cites W1981989535 @default.
• W2807187079 cites W1985989060 @default.
• W2807187079 cites W1989091022 @default.
• W2807187079 cites W1989743056 @default.
• W2807187079 cites W1991908200 @default.
• W2807187079 cites W1992760392 @default.
• W2807187079 cites W2003569476 @default.
• W2807187079 cites W2014187441 @default.
• W2807187079 cites W2015825998 @default.
• W2807187079 cites W2020957576 @default.
• W2807187079 cites W2021396643 @default.
• W2807187079 cites W2021487943 @default.
• W2807187079 cites W2037803066 @default.
• W2807187079 cites W2039938791 @default.
• W2807187079 cites W2055919781 @default.
• W2807187079 cites W2103789431 @default.
• W2807187079 cites W2120103016 @default.
• W2807187079 cites W2128882353 @default.
• W2807187079 cites W2134333066 @default.
• W2807187079 cites W2140320696 @default.
• W2807187079 cites W2141566488 @default.
• W2807187079 cites W2153104828 @default.
• W2807187079 cites W2162341191 @default.
• W2807187079 cites W2188944400 @default.
• W2807187079 cites W2293039128 @default.
• W2807187079 cites W2329613741 @default.
• W2807187079 cites W2332433933 @default.
• W2807187079 cites W2338587759 @default.
• W2807187079 cites W2508495018 @default.
• W2807187079 cites W4211120843 @default.
• W2807187079 cites W43292860 @default.
• W2807187079 doi "https://doi.org/10.18632/oncotarget.25514" @default.
• W2807187079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6007947" @default.
• W2807187079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29938001" @default.
• W2807187079 hasPublicationYear "2018" @default.
• W2807187079 type Work @default.
• W2807187079 sameAs 2807187079 @default.
• W2807187079 citedByCount "12" @default.
• W2807187079 countsByYear W28071870792018 @default.
• W2807187079 countsByYear W28071870792019 @default.
• W2807187079 countsByYear W28071870792020 @default.
• W2807187079 countsByYear W28071870792021 @default.
• W2807187079 countsByYear W28071870792022 @default.
• W2807187079 crossrefType "journal-article" @default.
• W2807187079 hasAuthorship W2807187079A5003890903 @default.
• W2807187079 hasAuthorship W2807187079A5004255429 @default.
• W2807187079 hasAuthorship W2807187079A5011758706 @default.
• W2807187079 hasAuthorship W2807187079A5027208541 @default.
• W2807187079 hasAuthorship W2807187079A5036627244 @default.
• W2807187079 hasAuthorship W2807187079A5041526466 @default.
• W2807187079 hasAuthorship W2807187079A5046980267 @default.
• W2807187079 hasAuthorship W2807187079A5055901701 @default.
• W2807187079 hasAuthorship W2807187079A5062263745 @default.
• W2807187079 hasAuthorship W2807187079A5064802518 @default.
• W2807187079 hasAuthorship W2807187079A5068656298 @default.
• W2807187079 hasAuthorship W2807187079A5077540798 @default.
• W2807187079 hasAuthorship W2807187079A5084534217 @default.
• W2807187079 hasBestOaLocation W28071870791 @default.
• W2807187079 hasConcept C121608353 @default.
• W2807187079 hasConcept C126322002 @default.
• W2807187079 hasConcept C2777387746 @default.
• W2807187079 hasConcept C2989005 @default.
• W2807187079 hasConcept C526805850 @default.
• W2807187079 hasConcept C71924100 @default.
• W2807187079 hasConceptScore W2807187079C121608353 @default.
• W2807187079 hasConceptScore W2807187079C126322002 @default.
• W2807187079 hasConceptScore W2807187079C2777387746 @default.
• W2807187079 hasConceptScore W2807187079C2989005 @default.
• W2807187079 hasConceptScore W2807187079C526805850 @default.
• W2807187079 hasConceptScore W2807187079C71924100 @default.
• W2807187079 hasIssue "44" @default.
• W2807187079 hasLocation W28071870791 @default.
• W2807187079 hasLocation W28071870792 @default.
• W2807187079 hasLocation W28071870793 @default.
• W2807187079 hasLocation W28071870794 @default.
• W2807187079 hasLocation W28071870795 @default.
• W2807187079 hasLocation W28071870796 @default.
• W2807187079 hasOpenAccess W2807187079 @default.

• next