Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807208608> ?p ?o ?g. }
- W2807208608 endingPage "2562" @default.
- W2807208608 startingPage "2552" @default.
- W2807208608 abstract "Consensus-designed tetratricopeptide repeat proteins are highly stable, modular proteins that are strikingly amenable to rational engineering. They therefore have tremendous potential as building blocks for biomaterials and biomedicine. Here, we explore the possibility of extending the loops between repeats to enable further diversification, and we investigate how this modification affects stability and folding cooperativity. We find that extending a single loop by up to 25 residues does not disrupt the overall protein structure, but, strikingly, the effect on stability is highly context-dependent: in a two-repeat array, destabilization is relatively small and can be accounted for purely in entropic terms, whereas extending a loop in the middle of a large array is much more costly because of weakening of the interaction between the repeats. Our findings provide important and, to our knowledge, new insights that increase our understanding of the structure, folding, and function of natural repeat proteins and the design of artificial repeat proteins in biotechnology." @default.
- W2807208608 created "2018-06-13" @default.
- W2807208608 creator A5016533330 @default.
- W2807208608 creator A5019410628 @default.
- W2807208608 creator A5043085718 @default.
- W2807208608 creator A5052850050 @default.
- W2807208608 date "2018-06-01" @default.
- W2807208608 modified "2023-09-27" @default.
- W2807208608 title "Context-Dependent Energetics of Loop Extensions in a Family of Tandem-Repeat Proteins" @default.
- W2807208608 cites W1967708206 @default.
- W2807208608 cites W1979319736 @default.
- W2807208608 cites W1985189873 @default.
- W2807208608 cites W1987392010 @default.
- W2807208608 cites W1988977510 @default.
- W2807208608 cites W1990539801 @default.
- W2807208608 cites W1992854770 @default.
- W2807208608 cites W1993166171 @default.
- W2807208608 cites W1996113127 @default.
- W2807208608 cites W1997828975 @default.
- W2807208608 cites W1997980045 @default.
- W2807208608 cites W2006911881 @default.
- W2807208608 cites W2008494223 @default.
- W2807208608 cites W2020563037 @default.
- W2807208608 cites W2028240922 @default.
- W2807208608 cites W2028320405 @default.
- W2807208608 cites W2033619224 @default.
- W2807208608 cites W2043862155 @default.
- W2807208608 cites W2049631853 @default.
- W2807208608 cites W2050648087 @default.
- W2807208608 cites W2054681398 @default.
- W2807208608 cites W2054927274 @default.
- W2807208608 cites W2062584177 @default.
- W2807208608 cites W2065884669 @default.
- W2807208608 cites W2069288811 @default.
- W2807208608 cites W2069871720 @default.
- W2807208608 cites W2070395999 @default.
- W2807208608 cites W2076406620 @default.
- W2807208608 cites W2076557859 @default.
- W2807208608 cites W2084155781 @default.
- W2807208608 cites W2084679948 @default.
- W2807208608 cites W2092803887 @default.
- W2807208608 cites W2097962012 @default.
- W2807208608 cites W2101164001 @default.
- W2807208608 cites W2107193227 @default.
- W2807208608 cites W2115746274 @default.
- W2807208608 cites W2117747873 @default.
- W2807208608 cites W2119509064 @default.
- W2807208608 cites W2126189887 @default.
- W2807208608 cites W2129328366 @default.
- W2807208608 cites W2148483912 @default.
- W2807208608 cites W2149647521 @default.
- W2807208608 cites W2152044968 @default.
- W2807208608 cites W2152236999 @default.
- W2807208608 cites W2163814597 @default.
- W2807208608 cites W2164148522 @default.
- W2807208608 cites W2188629183 @default.
- W2807208608 cites W2205148961 @default.
- W2807208608 cites W2291572297 @default.
- W2807208608 cites W2442760188 @default.
- W2807208608 cites W2734345364 @default.
- W2807208608 cites W2747985915 @default.
- W2807208608 cites W2785152208 @default.
- W2807208608 cites W56901349 @default.
- W2807208608 doi "https://doi.org/10.1016/j.bpj.2018.03.038" @default.
- W2807208608 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6129472" @default.
- W2807208608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29874606" @default.
- W2807208608 hasPublicationYear "2018" @default.
- W2807208608 type Work @default.
- W2807208608 sameAs 2807208608 @default.
- W2807208608 citedByCount "10" @default.
- W2807208608 countsByYear W28072086082019 @default.
- W2807208608 countsByYear W28072086082021 @default.
- W2807208608 countsByYear W28072086082022 @default.
- W2807208608 crossrefType "journal-article" @default.
- W2807208608 hasAuthorship W2807208608A5016533330 @default.
- W2807208608 hasAuthorship W2807208608A5019410628 @default.
- W2807208608 hasAuthorship W2807208608A5043085718 @default.
- W2807208608 hasAuthorship W2807208608A5052850050 @default.
- W2807208608 hasBestOaLocation W28072086081 @default.
- W2807208608 hasConcept C101468663 @default.
- W2807208608 hasConcept C104317684 @default.
- W2807208608 hasConcept C111919701 @default.
- W2807208608 hasConcept C119599485 @default.
- W2807208608 hasConcept C12554922 @default.
- W2807208608 hasConcept C127413603 @default.
- W2807208608 hasConcept C151730666 @default.
- W2807208608 hasConcept C152769699 @default.
- W2807208608 hasConcept C166014724 @default.
- W2807208608 hasConcept C185592680 @default.
- W2807208608 hasConcept C188018408 @default.
- W2807208608 hasConcept C204328495 @default.
- W2807208608 hasConcept C2776545253 @default.
- W2807208608 hasConcept C2779343474 @default.
- W2807208608 hasConcept C41008148 @default.
- W2807208608 hasConcept C47701112 @default.
- W2807208608 hasConcept C54355233 @default.
- W2807208608 hasConcept C55493867 @default.
- W2807208608 hasConcept C70721500 @default.