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- W2807241338 abstract "β-lactamases, which are found in several bacterial species and environments, are the main cause of resistance to β-lactams in Gram-negative bacteria. In 2009, a protein (LRA-13) with two β-lactamase domains (one class C domain and one class D domain) was experimentally characterised, and an extended action spectrum against β-lactams consistent with two functional domains was found. Here, we present the results of searches in the non-redundant NCBI protein database that revealed the existence of a group of homologous bifunctional β-lactamases in the genomes of environmental bacteria. These findings suggest that bifunctional β-lactamases are widespread in nature; these findings also raise concern that bifunctional β-lactamases may be transferred to bacteria of clinical importance through lateral gene transfer mechanisms." @default.
- W2807241338 created "2018-06-13" @default.
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- W2807241338 date "2018-05-28" @default.
- W2807241338 modified "2023-10-16" @default.
- W2807241338 title "Genomic analysis of bifunctional Class C-Class D β-lactamases in environmental bacteria" @default.
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- W2807241338 doi "https://doi.org/10.1590/0074-02760180098" @default.
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