Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807244102> ?p ?o ?g. }
- W2807244102 endingPage "1792" @default.
- W2807244102 startingPage "1783" @default.
- W2807244102 abstract "Functional respiratory imaging: heterogeneity of acute exacerbations of COPD Wouter H van Geffen,1,2 Bita Hajian,3 Wim Vos,4 Jan De Backer,4 Anthony Cahn,5 Omar S Usmani,6 Cedric Van Holsbeke,4 Massimo Pistolesi,7 Huib AM Kerstjens,2 Wilfried De Backer3 1Department of Respiratory Medicine, Medical Centre Leeuwarden, Leeuwarden, the Netherlands; 2Department of Pulmonary Diseases, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, University of Groningen, the Netherlands; 3Department of Pulmonary Diseases, Antwerp University Hospital, Antwerp, Belgium; 4FLUIDDA nv, Kontich, Belgium; 5GlaxoSmithKline R&D, Stevenage, UK; 6Faculty of Medicine, National Heart & Lung Institute, Imperial College London, London, UK; 7Department of Experimental and Clinical Medicine, Section of Respiratory Medicine, University of Florence, Florence, Italy Background: Exacerbations of COPD are a major burden to patients, and yet little is understood about heterogeneity. It contributes to the current persistent one-size-fits-all treatment. To replace this treatment by more personalized, precision medicine, new insights are required. We assessed the heterogeneity of exacerbations by functional respiratory imaging (FRI) in 3-dimensional models of airways and lungs. Methods: The trial was designed as a multicenter trial of patients with an acute exacerbation of COPD who were assessed by FRI, pulmonary function tests, and patient-reported outcomes, both in the acute stage and during resolution. Results: Forty seven patients were assessed. FRI analyses showed significant improvements in hyperinflation (a decrease in total volume at functional residual capacity of -0.25±0.61 L, p≤0.01), airway volume at total lung capacity (+1.70±4.65 L, p=0.02), and airway resistance. As expected, these improvements correlated partially with changes in the quality of life and in conventional lung function test parameters. Patients with the same changes in pulmonary function differ in regional disease activity measured by FRI. Conclusion: FRI is a useful tool to get a better insight into exacerbations of COPD, and significant improvements in its indices can be demonstrated from the acute phase to resolution even in relatively small groups. It clearly visualizes the marked variability within and between individuals in ventilation and resistance during exacerbations and is a tool for the assessment of the heterogeneity of COPD exacerbations. Keywords: COPD exacerbations, FRI, hyperinflation, chronic obstructive pulmonary disease, symptoms, heterogeneity" @default.
- W2807244102 created "2018-06-13" @default.
- W2807244102 creator A5004204265 @default.
- W2807244102 creator A5013428765 @default.
- W2807244102 creator A5019899932 @default.
- W2807244102 creator A5027083731 @default.
- W2807244102 creator A5032403798 @default.
- W2807244102 creator A5045112331 @default.
- W2807244102 creator A5047225743 @default.
- W2807244102 creator A5059657782 @default.
- W2807244102 creator A5060082670 @default.
- W2807244102 creator A5085759051 @default.
- W2807244102 date "2018-05-01" @default.
- W2807244102 modified "2023-09-27" @default.
- W2807244102 title "Functional respiratory imaging: heterogeneity of acute exacerbations of COPD" @default.
- W2807244102 cites W1542658837 @default.
- W2807244102 cites W1947273666 @default.
- W2807244102 cites W1962197481 @default.
- W2807244102 cites W1967981332 @default.
- W2807244102 cites W1999650696 @default.
- W2807244102 cites W2020912744 @default.
- W2807244102 cites W2021355637 @default.
- W2807244102 cites W2038366968 @default.
- W2807244102 cites W2051400033 @default.
- W2807244102 cites W2072228223 @default.
- W2807244102 cites W2078552229 @default.
- W2807244102 cites W2081185091 @default.
- W2807244102 cites W2105118811 @default.
- W2807244102 cites W2108290557 @default.
- W2807244102 cites W2121310476 @default.
- W2807244102 cites W2123272986 @default.
- W2807244102 cites W2123545513 @default.
- W2807244102 cites W2125078269 @default.
- W2807244102 cites W2154466524 @default.
- W2807244102 cites W2217280470 @default.
- W2807244102 cites W2230075589 @default.
- W2807244102 cites W2270582105 @default.
- W2807244102 cites W2419906873 @default.
- W2807244102 cites W2525468146 @default.
- W2807244102 cites W2615780746 @default.
- W2807244102 cites W2650295161 @default.
- W2807244102 doi "https://doi.org/10.2147/copd.s152463" @default.
- W2807244102 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5985851" @default.
- W2807244102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29881268" @default.
- W2807244102 hasPublicationYear "2018" @default.
- W2807244102 type Work @default.
- W2807244102 sameAs 2807244102 @default.
- W2807244102 citedByCount "8" @default.
- W2807244102 countsByYear W28072441022019 @default.
- W2807244102 countsByYear W28072441022020 @default.
- W2807244102 countsByYear W28072441022021 @default.
- W2807244102 countsByYear W28072441022022 @default.
- W2807244102 countsByYear W28072441022023 @default.
- W2807244102 crossrefType "journal-article" @default.
- W2807244102 hasAuthorship W2807244102A5004204265 @default.
- W2807244102 hasAuthorship W2807244102A5013428765 @default.
- W2807244102 hasAuthorship W2807244102A5019899932 @default.
- W2807244102 hasAuthorship W2807244102A5027083731 @default.
- W2807244102 hasAuthorship W2807244102A5032403798 @default.
- W2807244102 hasAuthorship W2807244102A5045112331 @default.
- W2807244102 hasAuthorship W2807244102A5047225743 @default.
- W2807244102 hasAuthorship W2807244102A5059657782 @default.
- W2807244102 hasAuthorship W2807244102A5060082670 @default.
- W2807244102 hasAuthorship W2807244102A5085759051 @default.
- W2807244102 hasBestOaLocation W28072441021 @default.
- W2807244102 hasConcept C126322002 @default.
- W2807244102 hasConcept C141071460 @default.
- W2807244102 hasConcept C177713679 @default.
- W2807244102 hasConcept C2776042228 @default.
- W2807244102 hasConcept C2776780178 @default.
- W2807244102 hasConcept C2777012970 @default.
- W2807244102 hasConcept C2777014857 @default.
- W2807244102 hasConcept C534529494 @default.
- W2807244102 hasConcept C71924100 @default.
- W2807244102 hasConceptScore W2807244102C126322002 @default.
- W2807244102 hasConceptScore W2807244102C141071460 @default.
- W2807244102 hasConceptScore W2807244102C177713679 @default.
- W2807244102 hasConceptScore W2807244102C2776042228 @default.
- W2807244102 hasConceptScore W2807244102C2776780178 @default.
- W2807244102 hasConceptScore W2807244102C2777012970 @default.
- W2807244102 hasConceptScore W2807244102C2777014857 @default.
- W2807244102 hasConceptScore W2807244102C534529494 @default.
- W2807244102 hasConceptScore W2807244102C71924100 @default.
- W2807244102 hasLocation W28072441021 @default.
- W2807244102 hasLocation W28072441022 @default.
- W2807244102 hasLocation W28072441023 @default.
- W2807244102 hasLocation W28072441024 @default.
- W2807244102 hasLocation W28072441025 @default.
- W2807244102 hasLocation W28072441026 @default.
- W2807244102 hasLocation W28072441027 @default.
- W2807244102 hasLocation W28072441028 @default.
- W2807244102 hasOpenAccess W2807244102 @default.
- W2807244102 hasPrimaryLocation W28072441021 @default.
- W2807244102 hasRelatedWork W1861423403 @default.
- W2807244102 hasRelatedWork W1974526650 @default.
- W2807244102 hasRelatedWork W2052775590 @default.
- W2807244102 hasRelatedWork W2077638660 @default.
- W2807244102 hasRelatedWork W2187214054 @default.