Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807260013> ?p ?o ?g. }
- W2807260013 abstract "Angelman syndrome (AS) is a neurodevelopmental disorder characterized by intellectual disability, speech and motor impairments, epilepsy, abnormal sleep, and phenotypic overlap with autism. Individuals with AS display characteristic EEG patterns including high-amplitude rhythmic delta waves. Here, we sought to quantitatively explore EEG architecture in AS beyond known spectral power phenotypes. We were motivated by studies of functional connectivity and sleep spindles in autism to study these EEG readouts in children with AS. We analyzed retrospective wake and sleep EEGs from children with AS (age 4–11) and age-matched neurotypical controls. We assessed long-range and short-range functional connectivity by measuring coherence across multiple frequencies during wake and sleep. We quantified sleep spindles using automated and manual approaches. During wakefulness, children with AS showed enhanced long-range EEG coherence across a wide range of frequencies. During sleep, children with AS showed increased long-range EEG coherence specifically in the gamma band. EEGs from children with AS contained fewer sleep spindles, and these spindles were shorter in duration than their neurotypical counterparts. We demonstrate two quantitative readouts of dysregulated sleep composition in children with AS—gamma coherence and spindles—and describe how functional connectivity patterns may be disrupted during wakefulness. Quantitative EEG phenotypes have potential as biomarkers and readouts of target engagement for future clinical trials and provide clues into how neural circuits are dysregulated in children with AS." @default.
- W2807260013 created "2018-06-13" @default.
- W2807260013 creator A5005713005 @default.
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- W2807260013 date "2018-04-27" @default.
- W2807260013 modified "2023-10-16" @default.
- W2807260013 title "Abnormal coherence and sleep composition in children with Angelman syndrome: a retrospective EEG study" @default.
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- W2807260013 doi "https://doi.org/10.1186/s13229-018-0214-8" @default.
- W2807260013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5924514" @default.
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