FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807264878> ?p ?o ?g. }

• W2807264878 abstract "Asthma exacerbations are associated with the recruitment of neutrophils to the lungs. These cells release proteases and mediators, many of which act at G protein-coupled receptors (GPCRs) that couple via Gq to promote bronchoconstriction and inflammation. Common asthma therapeutics up-regulate expression of the regulator of G protein signalling (RGS), RGS2. As RGS2 reduces signaling from Gq-coupled GPCRs, we have defined role(s) for this GTPase-activating protein in an acute neutrophilic model of lung inflammation. Wild type and Rgs2−/− C57Bl6 mice were exposed to nebulized lipopolysaccharide (LPS). Lung function (respiratory system resistance and compliance) was measured using a SCIREQ flexivent small animal ventilator. Lung inflammation was assessed by histochemistry, cell counting and by cytokine and chemokine expression in bronchoalveolar lavage (BAL) fluid. Lipopolysaccharide inhalation induced transient airways hyperreactivity (AHR) and neutrophilic lung inflammation. While AHR and inflammation was greatest 3 h post-LPS exposure, BAL neutrophils persisted for 24 h. At 3 h post-LPS inhalation, multiple inflammatory cytokines (CSF2, CSF3, IL6, TNF) and chemokines (CCL3, CCL4, CXCL1, CXCL2) were highly expressed in the BAL fluid, prior to declining by 24 h. Compared to wild type counterparts, Rgs2−/− mice developed significantly greater airflow resistance in response to inhaled methacholine (MCh) at 3 h post-LPS exposure. At 24 h post-LPS exposure, when lung function was recovering in the wild type animals, MCh-induced resistance was increased, and compliance decreased, in Rgs2−/− mice. Thus, Rgs2−/− mice show AHR and stiffer lungs 24 h post-LPS exposure. Histological markers of inflammation, total and differential cell counts, and major cytokine and chemokine expression in BAL fluid were similar between wild type and Rgs2−/− mice. However, 3 and 24 h post-LPS exposure, IL12B expression was significantly elevated in BAL fluid from Rgs2−/− mice compared to wild type animals. While Rgs2 is bronchoprotective in acute neutrophilic inflammation, no clear anti-inflammatory effect was apparent. Nevertheless, elevated IL12B expression in Rgs2−/− animals raises the possibility that RGS2 could dampen Th1 responses. These findings indicate that up-regulation of RGS2, as occurs in response to inhaled corticosteroids and long-acting β2-adrenoceptor agonists, may be beneficial in acute neutrophilic exacerbations of airway disease, including asthma." @default.
• W2807264878 created "2018-06-13" @default.
• W2807264878 creator A5018753336 @default.
• W2807264878 creator A5027839167 @default.
• W2807264878 creator A5056761781 @default.
• W2807264878 creator A5068506060 @default.
• W2807264878 date "2018-10-01" @default.
• W2807264878 modified "2023-10-03" @default.
• W2807264878 title "A bronchoprotective role for Rgs2 in a murine model of lipopolysaccharide-induced airways inflammation" @default.
• W2807264878 cites W1598572197 @default.
• W2807264878 cites W1644695642 @default.
• W2807264878 cites W1845241969 @default.
• W2807264878 cites W1885711878 @default.
• W2807264878 cites W1902650061 @default.
• W2807264878 cites W1962209258 @default.
• W2807264878 cites W1966978776 @default.
• W2807264878 cites W1984721770 @default.
• W2807264878 cites W1985899209 @default.
• W2807264878 cites W1986967124 @default.
• W2807264878 cites W1989572440 @default.
• W2807264878 cites W1999274330 @default.
• W2807264878 cites W2001084487 @default.
• W2807264878 cites W2002631942 @default.
• W2807264878 cites W2007115912 @default.
• W2807264878 cites W2020258717 @default.
• W2807264878 cites W2021743082 @default.
• W2807264878 cites W2028676214 @default.
• W2807264878 cites W2029478951 @default.
• W2807264878 cites W2033038444 @default.
• W2807264878 cites W2033330877 @default.
• W2807264878 cites W2033885494 @default.
• W2807264878 cites W2037701784 @default.
• W2807264878 cites W2038407645 @default.
• W2807264878 cites W2039796247 @default.
• W2807264878 cites W2045915987 @default.
• W2807264878 cites W2046290595 @default.
• W2807264878 cites W2049359083 @default.
• W2807264878 cites W2053798956 @default.
• W2807264878 cites W2055492964 @default.
• W2807264878 cites W2055685990 @default.
• W2807264878 cites W2066266627 @default.
• W2807264878 cites W2067837436 @default.
• W2807264878 cites W2070841999 @default.
• W2807264878 cites W2071342874 @default.
• W2807264878 cites W2079107760 @default.
• W2807264878 cites W2085231708 @default.
• W2807264878 cites W2090288719 @default.
• W2807264878 cites W2091263231 @default.
• W2807264878 cites W2107623090 @default.
• W2807264878 cites W2112732958 @default.
• W2807264878 cites W2113830065 @default.
• W2807264878 cites W2126049681 @default.
• W2807264878 cites W2131374289 @default.
• W2807264878 cites W2131937634 @default.
• W2807264878 cites W2132955895 @default.
• W2807264878 cites W2135599949 @default.
• W2807264878 cites W2135982053 @default.
• W2807264878 cites W2137509535 @default.
• W2807264878 cites W2138512207 @default.
• W2807264878 cites W2142495381 @default.
• W2807264878 cites W2143166807 @default.
• W2807264878 cites W2143903809 @default.
• W2807264878 cites W2144674546 @default.
• W2807264878 cites W2146036781 @default.
• W2807264878 cites W2147639753 @default.
• W2807264878 cites W2150918229 @default.
• W2807264878 cites W2151441249 @default.
• W2807264878 cites W2155963054 @default.
• W2807264878 cites W2160419207 @default.
• W2807264878 cites W2164402028 @default.
• W2807264878 cites W2169368809 @default.
• W2807264878 cites W2171135911 @default.
• W2807264878 cites W2179510469 @default.
• W2807264878 cites W2313256289 @default.
• W2807264878 cites W2345324041 @default.
• W2807264878 cites W2475211826 @default.
• W2807264878 cites W2523576980 @default.
• W2807264878 cites W2525373367 @default.
• W2807264878 cites W2573090672 @default.
• W2807264878 cites W2599419818 @default.
• W2807264878 cites W2606691050 @default.
• W2807264878 cites W2760171305 @default.
• W2807264878 cites W2780371039 @default.
• W2807264878 doi "https://doi.org/10.1186/s13223-018-0266-5" @default.
• W2807264878 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6166284" @default.
• W2807264878 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30305828" @default.
• W2807264878 hasPublicationYear "2018" @default.
• W2807264878 type Work @default.
• W2807264878 sameAs 2807264878 @default.
• W2807264878 citedByCount "17" @default.
• W2807264878 countsByYear W28072648782020 @default.
• W2807264878 countsByYear W28072648782021 @default.
• W2807264878 countsByYear W28072648782022 @default.
• W2807264878 countsByYear W28072648782023 @default.
• W2807264878 crossrefType "journal-article" @default.
• W2807264878 hasAuthorship W2807264878A5018753336 @default.
• W2807264878 hasAuthorship W2807264878A5027839167 @default.
• W2807264878 hasAuthorship W2807264878A5056761781 @default.
• W2807264878 hasAuthorship W2807264878A5068506060 @default.
• W2807264878 hasBestOaLocation W28072648781 @default.

• next