FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807268775> ?p ?o ?g. }

• W2807268775 endingPage "348" @default.
• W2807268775 startingPage "341" @default.
• W2807268775 abstract "Radiation-induced lung injury (RILI) is the main complication of radiotherapy for thoracic malignancies. Since naringenin, a potent immune-modulator, has been found to relieve bleomycin-induced lung fibrosis by restoring the balance of disordered cytokines, we sought to determine whether naringenin would mitigate RILI and to investigate the underlying mechanism. Animals received fractionated irradiation in the thoracic area to induce RILI. Enzyme-linked immunosorbent assay and MILLIPLEX assays were used for serum and bronchoalveolar lavage fluid for cytokine analyses, hematoxylin and eosin staining for pathologic changes, and Masson trichrome staining for determination of lung fibrosis. Interleukin (IL)-1β was found significantly elevated after thoracic irradiation and it triggered production of profibrotic tumor growth factor β both in vivo and in vitro, suggesting the vital role of in IL-1β in the development of RILI. Furthermore, we found that naringenin was able to ameliorate RILI through downregulation of IL-1β and restoration of the homeostasis of inflammatory factors. Our results demonstrated that naringenin could serve as a potent immune-modulator to ameliorate RILI. More importantly, we suggest that a new complementary strategy of maintaining the homeostasis of inflammatory factors combined with radiation could improve the efficacy of thoracic radiotherapy." @default.
• W2807268775 created "2018-06-13" @default.
• W2807268775 creator A5003312656 @default.
• W2807268775 creator A5003341533 @default.
• W2807268775 creator A5005691707 @default.
• W2807268775 creator A5033490134 @default.
• W2807268775 creator A5039160183 @default.
• W2807268775 creator A5044026422 @default.
• W2807268775 creator A5066933998 @default.
• W2807268775 creator A5075653086 @default.
• W2807268775 creator A5087249304 @default.
• W2807268775 creator A5087695394 @default.
• W2807268775 creator A5089966579 @default.
• W2807268775 creator A5090608501 @default.
• W2807268775 date "2018-06-04" @default.
• W2807268775 modified "2023-10-11" @default.
• W2807268775 title "Naringenin Ameliorates Radiation-Induced Lung Injury by Lowering IL-1<i>β</i> Level" @default.
• W2807268775 cites W1881291036 @default.
• W2807268775 cites W1965774491 @default.
• W2807268775 cites W1977373639 @default.
• W2807268775 cites W1984032738 @default.
• W2807268775 cites W1988380701 @default.
• W2807268775 cites W1989450022 @default.
• W2807268775 cites W1992228359 @default.
• W2807268775 cites W1999644843 @default.
• W2807268775 cites W2000463136 @default.
• W2807268775 cites W2005773735 @default.
• W2807268775 cites W2032076454 @default.
• W2807268775 cites W2033818125 @default.
• W2807268775 cites W2051178076 @default.
• W2807268775 cites W2064119928 @default.
• W2807268775 cites W2095715691 @default.
• W2807268775 cites W2100379694 @default.
• W2807268775 cites W2114918801 @default.
• W2807268775 cites W2124912046 @default.
• W2807268775 cites W2127383660 @default.
• W2807268775 cites W2131498101 @default.
• W2807268775 cites W2146994220 @default.
• W2807268775 cites W2150107812 @default.
• W2807268775 cites W2153078739 @default.
• W2807268775 cites W2164437838 @default.
• W2807268775 cites W2168502452 @default.
• W2807268775 cites W2324168617 @default.
• W2807268775 cites W2342846323 @default.
• W2807268775 cites W2511177500 @default.
• W2807268775 cites W2516303439 @default.
• W2807268775 cites W2601956340 @default.
• W2807268775 cites W2761832333 @default.
• W2807268775 cites W2995442355 @default.
• W2807268775 doi "https://doi.org/10.1124/jpet.118.248807" @default.
• W2807268775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29866791" @default.
• W2807268775 hasPublicationYear "2018" @default.
• W2807268775 type Work @default.
• W2807268775 sameAs 2807268775 @default.
• W2807268775 citedByCount "29" @default.
• W2807268775 countsByYear W28072687752018 @default.
• W2807268775 countsByYear W28072687752019 @default.
• W2807268775 countsByYear W28072687752020 @default.
• W2807268775 countsByYear W28072687752021 @default.
• W2807268775 countsByYear W28072687752022 @default.
• W2807268775 countsByYear W28072687752023 @default.
• W2807268775 crossrefType "journal-article" @default.
• W2807268775 hasAuthorship W2807268775A5003312656 @default.
• W2807268775 hasAuthorship W2807268775A5003341533 @default.
• W2807268775 hasAuthorship W2807268775A5005691707 @default.
• W2807268775 hasAuthorship W2807268775A5033490134 @default.
• W2807268775 hasAuthorship W2807268775A5039160183 @default.
• W2807268775 hasAuthorship W2807268775A5044026422 @default.
• W2807268775 hasAuthorship W2807268775A5066933998 @default.
• W2807268775 hasAuthorship W2807268775A5075653086 @default.
• W2807268775 hasAuthorship W2807268775A5087249304 @default.
• W2807268775 hasAuthorship W2807268775A5087695394 @default.
• W2807268775 hasAuthorship W2807268775A5089966579 @default.
• W2807268775 hasAuthorship W2807268775A5090608501 @default.
• W2807268775 hasBestOaLocation W28072687751 @default.
• W2807268775 hasConcept C104317684 @default.
• W2807268775 hasConcept C126322002 @default.
• W2807268775 hasConcept C127561419 @default.
• W2807268775 hasConcept C142724271 @default.
• W2807268775 hasConcept C2776232574 @default.
• W2807268775 hasConcept C2776694085 @default.
• W2807268775 hasConcept C2776848411 @default.
• W2807268775 hasConcept C2777714996 @default.
• W2807268775 hasConcept C2777961210 @default.
• W2807268775 hasConcept C2778004101 @default.
• W2807268775 hasConcept C2779054382 @default.
• W2807268775 hasConcept C2780559512 @default.
• W2807268775 hasConcept C2781244666 @default.
• W2807268775 hasConcept C502942594 @default.
• W2807268775 hasConcept C55493867 @default.
• W2807268775 hasConcept C71924100 @default.
• W2807268775 hasConcept C86803240 @default.
• W2807268775 hasConcept C98274493 @default.
• W2807268775 hasConceptScore W2807268775C104317684 @default.
• W2807268775 hasConceptScore W2807268775C126322002 @default.
• W2807268775 hasConceptScore W2807268775C127561419 @default.
• W2807268775 hasConceptScore W2807268775C142724271 @default.
• W2807268775 hasConceptScore W2807268775C2776232574 @default.

• next