FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807297619> ?p ?o ?g. }

• W2807297619 abstract "We investigated the renoprotective ability of healthy people against kidney stone formation. To clarify intratubular crystal kinetics and processing in human kidneys, we performed a quantitative and morphological observation of nephrectomized renal parenchyma tissues. Clinical data and pathological samples from 60 patients who underwent radical nephrectomy for renal cancer were collected from June 2004 to June 2010. The patients were retrospectively classified as stone formers (SFs; n = 30, kidney stones detected by preoperative computed tomography) and non-stone formers (NSFs; n = 30, no kidney stone history). The morphology of parenchymal intratubular crystals and kidney stone-related gene and protein expression levels were examined in noncancerous renal sections from both groups. SFs had a higher smoking rate (P = 0.0097); lower red blood cell, hemoglobin, and hematocrit values; and higher urinary red blood cell, white blood cell, and bacterial counts than NSFs. Scanning electron microscopy revealed calcium-containing crystal deposits and crystal attachment to the renal tubular lumen in both groups. Both groups demonstrated crystal transmigration from the tubular lumen to the interstitium. The crystal diffusion analysis indicated a significantly higher crystal existing ratio in the medulla and papilla of SFs and a significantly higher number of papillary crystal deposits in SFs than NSFs. The expression analysis indicated relatively high osteopontin and CD68, low superoxide dismutase, and significantly lower Tamm–Horsfall protein expression levels in SFs. Multivariate logistic regression analysis involving the above factors found the presence of renal papillary crystals as a significant independent factor related to SFs (odds ratio 5.55, 95% confidence interval 1.08–37.18, P = 0.0395). Regardless of stone formation, intratubular crystals in the renal parenchyma seem to transmigrate to the interstitium. SFs may have reduced ability to eliminate renal parenchymal crystals, particularly those in the papilla region, than NSFs with associated gene expression profiles." @default.
• W2807297619 created "2018-06-13" @default.
• W2807297619 creator A5007102867 @default.
• W2807297619 creator A5016484890 @default.
• W2807297619 creator A5028059624 @default.
• W2807297619 creator A5037793760 @default.
• W2807297619 creator A5058542472 @default.
• W2807297619 creator A5066401468 @default.
• W2807297619 creator A5073925535 @default.
• W2807297619 creator A5083445762 @default.
• W2807297619 creator A5085852791 @default.
• W2807297619 creator A5086194342 @default.
• W2807297619 date "2018-03-12" @default.
• W2807297619 modified "2023-10-17" @default.
• W2807297619 title "Kidney stone formers have more renal parenchymal crystals than non-stone formers, particularly in the papilla region" @default.
• W2807297619 cites W1964036343 @default.
• W2807297619 cites W1965943690 @default.
• W2807297619 cites W1971825577 @default.
• W2807297619 cites W1972273202 @default.
• W2807297619 cites W1979270243 @default.
• W2807297619 cites W1984352965 @default.
• W2807297619 cites W1985725629 @default.
• W2807297619 cites W1989785500 @default.
• W2807297619 cites W1992423032 @default.
• W2807297619 cites W2008429009 @default.
• W2807297619 cites W2013688634 @default.
• W2807297619 cites W2016391503 @default.
• W2807297619 cites W2033541643 @default.
• W2807297619 cites W2034082568 @default.
• W2807297619 cites W2035165464 @default.
• W2807297619 cites W2060928524 @default.
• W2807297619 cites W2063331569 @default.
• W2807297619 cites W2065473184 @default.
• W2807297619 cites W2067021754 @default.
• W2807297619 cites W2073769016 @default.
• W2807297619 cites W2076727310 @default.
• W2807297619 cites W2084917522 @default.
• W2807297619 cites W2089483710 @default.
• W2807297619 cites W2092325416 @default.
• W2807297619 cites W2095290585 @default.
• W2807297619 cites W2097044565 @default.
• W2807297619 cites W2103716351 @default.
• W2807297619 cites W2106237709 @default.
• W2807297619 cites W2112566720 @default.
• W2807297619 cites W2114681080 @default.
• W2807297619 cites W2115985004 @default.
• W2807297619 cites W2116381107 @default.
• W2807297619 cites W2117062848 @default.
• W2807297619 cites W2140265778 @default.
• W2807297619 cites W2151733411 @default.
• W2807297619 cites W2325365890 @default.
• W2807297619 cites W2426519065 @default.
• W2807297619 cites W2588237306 @default.
• W2807297619 cites W6323710 @default.
• W2807297619 doi "https://doi.org/10.1186/s12894-018-0331-x" @default.
• W2807297619 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5848581" @default.
• W2807297619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29530009" @default.
• W2807297619 hasPublicationYear "2018" @default.
• W2807297619 type Work @default.
• W2807297619 sameAs 2807297619 @default.
• W2807297619 citedByCount "16" @default.
• W2807297619 countsByYear W28072976192018 @default.
• W2807297619 countsByYear W28072976192019 @default.
• W2807297619 countsByYear W28072976192020 @default.
• W2807297619 countsByYear W28072976192021 @default.
• W2807297619 countsByYear W28072976192022 @default.
• W2807297619 countsByYear W28072976192023 @default.
• W2807297619 crossrefType "journal-article" @default.
• W2807297619 hasAuthorship W2807297619A5007102867 @default.
• W2807297619 hasAuthorship W2807297619A5016484890 @default.
• W2807297619 hasAuthorship W2807297619A5028059624 @default.
• W2807297619 hasAuthorship W2807297619A5037793760 @default.
• W2807297619 hasAuthorship W2807297619A5058542472 @default.
• W2807297619 hasAuthorship W2807297619A5066401468 @default.
• W2807297619 hasAuthorship W2807297619A5073925535 @default.
• W2807297619 hasAuthorship W2807297619A5083445762 @default.
• W2807297619 hasAuthorship W2807297619A5085852791 @default.
• W2807297619 hasAuthorship W2807297619A5086194342 @default.
• W2807297619 hasBestOaLocation W28072976191 @default.
• W2807297619 hasConcept C126322002 @default.
• W2807297619 hasConcept C126894567 @default.
• W2807297619 hasConcept C134984996 @default.
• W2807297619 hasConcept C142724271 @default.
• W2807297619 hasConcept C196822366 @default.
• W2807297619 hasConcept C2779403450 @default.
• W2807297619 hasConcept C2780091579 @default.
• W2807297619 hasConcept C2780227381 @default.
• W2807297619 hasConcept C2780371755 @default.
• W2807297619 hasConcept C71924100 @default.
• W2807297619 hasConceptScore W2807297619C126322002 @default.
• W2807297619 hasConceptScore W2807297619C126894567 @default.
• W2807297619 hasConceptScore W2807297619C134984996 @default.
• W2807297619 hasConceptScore W2807297619C142724271 @default.
• W2807297619 hasConceptScore W2807297619C196822366 @default.
• W2807297619 hasConceptScore W2807297619C2779403450 @default.
• W2807297619 hasConceptScore W2807297619C2780091579 @default.
• W2807297619 hasConceptScore W2807297619C2780227381 @default.
• W2807297619 hasConceptScore W2807297619C2780371755 @default.
• W2807297619 hasConceptScore W2807297619C71924100 @default.
• W2807297619 hasFunder F4320309807 @default.

• next