FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807306238> ?p ?o ?g. }

• W2807306238 abstract "Obstructive sleep apnea (OSA) is a well-established cause of impaired daytime functioning. However, there is a complex inter-individual variability in neurobehavioral performance in OSA patients. We previously reported compromised brain bioenergetics during apneic sleep in severe OSA. In this study, we investigate whether brain bioenergetics during resting wakefulness are related to neurobehavioral performance. Patients attended the sleep laboratory in the evening and were kept awake over-night. Repeated testing on the 10-minute psychomotor vigilance task (PVT, at 9 pm, 11 pm, 1 am, 3 am, 5 am) and 30-minute AusEd driving simulator task (9 pm and 5 am) was performed. Brain bioenergetics (inorganic phosphate/adenosine triphosphate ratio, Pi/ATP) were measured in the temporal lobe during resting wakefulness at 7 am in a 1.5T MRI scanner using phosphorus magnetic resonance spectroscopy (31P MRS). Fifteen males with severe OSA (age 47.7 ± 10.4 years, body mass index [BMI] 34 ± 6.6 kg/m2, apnea hypopnea index [AHI] 79.7 ± 21.8/hour) were investigated. A higher Pi/ATP ratio in the brain (lower phosphorylation potential) was correlated with worse PVT and driving simulator performance across the testing period (PVT lapses: r = 0.632, r2 = 0.399, p = 0.012; and AusEd braking reaction time: r = 0.609, p = 0.016). In contrast, the conventional AHI measure of disease severity was not significantly correlated with performance (PVT lapses: r = −0.084, p = 0.8; and AusEd braking reaction time: r = −0.326, p = 0.2). Lower phosphorylation potential was associated with worse performance. Compromised brain bioenergetics may in part underlie the neurobehavioral deficits in untreated OSA. We speculate that better brain bioenergetics may explain why some OSA patients are relatively asymptomatic compared with others." @default.
• W2807306238 created "2018-06-13" @default.
• W2807306238 creator A5007648400 @default.
• W2807306238 creator A5021013704 @default.
• W2807306238 creator A5038094539 @default.
• W2807306238 creator A5049136153 @default.
• W2807306238 creator A5058285879 @default.
• W2807306238 creator A5069774241 @default.
• W2807306238 creator A5082969975 @default.
• W2807306238 date "2018-06-01" @default.
• W2807306238 modified "2023-10-17" @default.
• W2807306238 title "Brain bioenergetics during resting wakefulness are related to neurobehavioral deficits in severe obstructive sleep apnea: a 31P magnetic resonance spectroscopy study" @default.
• W2807306238 cites W1504925078 @default.
• W2807306238 cites W1575552721 @default.
• W2807306238 cites W1581338941 @default.
• W2807306238 cites W1910963798 @default.
• W2807306238 cites W1912676390 @default.
• W2807306238 cites W1966657660 @default.
• W2807306238 cites W1968338807 @default.
• W2807306238 cites W197066864 @default.
• W2807306238 cites W1971416100 @default.
• W2807306238 cites W1976123087 @default.
• W2807306238 cites W2006264174 @default.
• W2807306238 cites W2009889155 @default.
• W2807306238 cites W2011114870 @default.
• W2807306238 cites W2015906010 @default.
• W2807306238 cites W2016153727 @default.
• W2807306238 cites W2030284843 @default.
• W2807306238 cites W2047307272 @default.
• W2807306238 cites W2064828367 @default.
• W2807306238 cites W2065856983 @default.
• W2807306238 cites W2069821327 @default.
• W2807306238 cites W2070842225 @default.
• W2807306238 cites W2080443097 @default.
• W2807306238 cites W2087555320 @default.
• W2807306238 cites W2090240067 @default.
• W2807306238 cites W2093037844 @default.
• W2807306238 cites W2099926839 @default.
• W2807306238 cites W2103213307 @default.
• W2807306238 cites W2103939721 @default.
• W2807306238 cites W2118194281 @default.
• W2807306238 cites W2122956038 @default.
• W2807306238 cites W2127249913 @default.
• W2807306238 cites W2134905559 @default.
• W2807306238 cites W2139720169 @default.
• W2807306238 cites W2153067765 @default.
• W2807306238 cites W2157614293 @default.
• W2807306238 cites W2162920459 @default.
• W2807306238 cites W2166252035 @default.
• W2807306238 cites W2167840686 @default.
• W2807306238 cites W2173526728 @default.
• W2807306238 cites W2264784497 @default.
• W2807306238 cites W2290432881 @default.
• W2807306238 cites W2315449384 @default.
• W2807306238 cites W2320141225 @default.
• W2807306238 cites W2325301090 @default.
• W2807306238 cites W2475006202 @default.
• W2807306238 cites W2750139094 @default.
• W2807306238 cites W2794237976 @default.
• W2807306238 doi "https://doi.org/10.1093/sleep/zsy117" @default.
• W2807306238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29868772" @default.
• W2807306238 hasPublicationYear "2018" @default.
• W2807306238 type Work @default.
• W2807306238 sameAs 2807306238 @default.
• W2807306238 citedByCount "5" @default.
• W2807306238 countsByYear W28073062382019 @default.
• W2807306238 countsByYear W28073062382021 @default.
• W2807306238 countsByYear W28073062382022 @default.
• W2807306238 countsByYear W28073062382023 @default.
• W2807306238 crossrefType "journal-article" @default.
• W2807306238 hasAuthorship W2807306238A5007648400 @default.
• W2807306238 hasAuthorship W2807306238A5021013704 @default.
• W2807306238 hasAuthorship W2807306238A5038094539 @default.
• W2807306238 hasAuthorship W2807306238A5049136153 @default.
• W2807306238 hasAuthorship W2807306238A5058285879 @default.
• W2807306238 hasAuthorship W2807306238A5069774241 @default.
• W2807306238 hasAuthorship W2807306238A5082969975 @default.
• W2807306238 hasBestOaLocation W28073062381 @default.
• W2807306238 hasConcept C100206155 @default.
• W2807306238 hasConcept C118552586 @default.
• W2807306238 hasConcept C121332964 @default.
• W2807306238 hasConcept C121446783 @default.
• W2807306238 hasConcept C126322002 @default.
• W2807306238 hasConcept C1276947 @default.
• W2807306238 hasConcept C15744967 @default.
• W2807306238 hasConcept C169760540 @default.
• W2807306238 hasConcept C185592680 @default.
• W2807306238 hasConcept C192769605 @default.
• W2807306238 hasConcept C2776006263 @default.
• W2807306238 hasConcept C2776476923 @default.
• W2807306238 hasConcept C2778329153 @default.
• W2807306238 hasConcept C2778553148 @default.
• W2807306238 hasConcept C2779320081 @default.
• W2807306238 hasConcept C2779494582 @default.
• W2807306238 hasConcept C2780714222 @default.
• W2807306238 hasConcept C28859421 @default.
• W2807306238 hasConcept C42219234 @default.
• W2807306238 hasConcept C522805319 @default.
• W2807306238 hasConcept C548259974 @default.
• W2807306238 hasConcept C55493867 @default.

• next