FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807310554> ?p ?o ?g. }

• W2807310554 endingPage "1710" @default.
• W2807310554 startingPage "1710" @default.
• W2807310554 abstract "AT-rich interactive domain 1A (ARID1A) and AT-rich interactive domain 1B (ARID1B) are subunits of the SWI/SNF chromatin complex. ARID1A is a tumor suppressor gene that is frequently mutated (46%) in ovarian clear cell carcinomas (OCCC). Loss of ARID1B in an ARID1A-deficient background eliminates the intact SWI/SNF complex, indicating that ARID1B is essential for the formation or stabilization of an intact SWI/SNF complex and, thus, the survival of ARID1A-mutant cancer cell lines. In this study, we investigated the clinicopathologic and prognostic relevance of ARID1B in OCCC by immunohistochemical analysis of 53 OCCC patient samples and loss-of-function experiments in OCCC cell lines. We also examined whether ARID1B could be a therapeutic target or prognostic biomarker in OCCC. siRNA-mediated knockdown of ARID1B in an ARID1A-mutant cell line significantly decreased cell growth, whereas concurrent depletion of both ARID1A and ARID1B was required to decrease wild type cell growth. In the immunohistochemical analyses, low ARID1B level was frequent in samples lacking ARID1A and was associated with shorter progression-free survival. This is the first report demonstrating that a low ARID1B level could be a marker of poor prognosis in OCCC. Moreover, the correlation between the loss of ARID1A immunoreactivity and reduced ARID1B levels indicates that ARID1B could be an attractive target for anti-cancer therapy." @default.
• W2807310554 created "2018-06-13" @default.
• W2807310554 creator A5010897098 @default.
• W2807310554 creator A5011728066 @default.
• W2807310554 creator A5027372184 @default.
• W2807310554 creator A5040402582 @default.
• W2807310554 creator A5057005039 @default.
• W2807310554 creator A5062260907 @default.
• W2807310554 creator A5062382610 @default.
• W2807310554 creator A5070007977 @default.
• W2807310554 creator A5082807098 @default.
• W2807310554 creator A5089743632 @default.
• W2807310554 date "2018-06-08" @default.
• W2807310554 modified "2023-10-01" @default.
• W2807310554 title "ARID1B as a Potential Therapeutic Target for ARID1A-Mutant Ovarian Clear Cell Carcinoma" @default.
• W2807310554 cites W1975141727 @default.
• W2807310554 cites W1983416548 @default.
• W2807310554 cites W1988124776 @default.
• W2807310554 cites W2001877789 @default.
• W2807310554 cites W2006818766 @default.
• W2807310554 cites W2025423482 @default.
• W2807310554 cites W2030312997 @default.
• W2807310554 cites W2034852369 @default.
• W2807310554 cites W2040730809 @default.
• W2807310554 cites W2045777875 @default.
• W2807310554 cites W2071168599 @default.
• W2807310554 cites W2077894744 @default.
• W2807310554 cites W2112612051 @default.
• W2807310554 cites W2112728955 @default.
• W2807310554 cites W2124652061 @default.
• W2807310554 cites W2320125475 @default.
• W2807310554 cites W2508098025 @default.
• W2807310554 doi "https://doi.org/10.3390/ijms19061710" @default.
• W2807310554 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6032401" @default.
• W2807310554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29890703" @default.
• W2807310554 hasPublicationYear "2018" @default.
• W2807310554 type Work @default.
• W2807310554 sameAs 2807310554 @default.
• W2807310554 citedByCount "20" @default.
• W2807310554 countsByYear W28073105542019 @default.
• W2807310554 countsByYear W28073105542020 @default.
• W2807310554 countsByYear W28073105542021 @default.
• W2807310554 countsByYear W28073105542022 @default.
• W2807310554 countsByYear W28073105542023 @default.
• W2807310554 crossrefType "journal-article" @default.
• W2807310554 hasAuthorship W2807310554A5010897098 @default.
• W2807310554 hasAuthorship W2807310554A5011728066 @default.
• W2807310554 hasAuthorship W2807310554A5027372184 @default.
• W2807310554 hasAuthorship W2807310554A5040402582 @default.
• W2807310554 hasAuthorship W2807310554A5057005039 @default.
• W2807310554 hasAuthorship W2807310554A5062260907 @default.
• W2807310554 hasAuthorship W2807310554A5062382610 @default.
• W2807310554 hasAuthorship W2807310554A5070007977 @default.
• W2807310554 hasAuthorship W2807310554A5082807098 @default.
• W2807310554 hasAuthorship W2807310554A5089743632 @default.
• W2807310554 hasBestOaLocation W28073105541 @default.
• W2807310554 hasConcept C104317684 @default.
• W2807310554 hasConcept C121608353 @default.
• W2807310554 hasConcept C143065580 @default.
• W2807310554 hasConcept C167227067 @default.
• W2807310554 hasConcept C173396325 @default.
• W2807310554 hasConcept C203014093 @default.
• W2807310554 hasConcept C204232928 @default.
• W2807310554 hasConcept C2778560582 @default.
• W2807310554 hasConcept C2781199814 @default.
• W2807310554 hasConcept C2781273526 @default.
• W2807310554 hasConcept C501734568 @default.
• W2807310554 hasConcept C502942594 @default.
• W2807310554 hasConcept C54355233 @default.
• W2807310554 hasConcept C62112901 @default.
• W2807310554 hasConcept C81885089 @default.
• W2807310554 hasConcept C83640560 @default.
• W2807310554 hasConcept C86803240 @default.
• W2807310554 hasConceptScore W2807310554C104317684 @default.
• W2807310554 hasConceptScore W2807310554C121608353 @default.
• W2807310554 hasConceptScore W2807310554C143065580 @default.
• W2807310554 hasConceptScore W2807310554C167227067 @default.
• W2807310554 hasConceptScore W2807310554C173396325 @default.
• W2807310554 hasConceptScore W2807310554C203014093 @default.
• W2807310554 hasConceptScore W2807310554C204232928 @default.
• W2807310554 hasConceptScore W2807310554C2778560582 @default.
• W2807310554 hasConceptScore W2807310554C2781199814 @default.
• W2807310554 hasConceptScore W2807310554C2781273526 @default.
• W2807310554 hasConceptScore W2807310554C501734568 @default.
• W2807310554 hasConceptScore W2807310554C502942594 @default.
• W2807310554 hasConceptScore W2807310554C54355233 @default.
• W2807310554 hasConceptScore W2807310554C62112901 @default.
• W2807310554 hasConceptScore W2807310554C81885089 @default.
• W2807310554 hasConceptScore W2807310554C83640560 @default.
• W2807310554 hasConceptScore W2807310554C86803240 @default.
• W2807310554 hasIssue "6" @default.
• W2807310554 hasLocation W28073105541 @default.
• W2807310554 hasLocation W28073105542 @default.
• W2807310554 hasLocation W28073105543 @default.
• W2807310554 hasLocation W28073105544 @default.
• W2807310554 hasLocation W28073105545 @default.
• W2807310554 hasOpenAccess W2807310554 @default.
• W2807310554 hasPrimaryLocation W28073105541 @default.

• next