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- W2807328311 abstract "Chlorogenic acid (CGA) has been reported to exhibit potent anti-inflammatory activity. However, the development of anti-inflammatory agent based on CGA has not been investigated. In this paper, a series of caffeoyl salicylate compounds derived from CGA were designed, synthesized, and evaluated by LPS-induced nitric oxide synthase inhibition and QRT-PCR technique. Most compounds showed modest activity to inhibit production of nitric oxide (NO) in RAW 264.7 cells induced by lipopolysaccharides (LPS). Among these compounds, QRT-PCR and western blotting results indicated that compounds 6b, 6c, 6f, 6g and D104 that possess 5-member ring or 6-member ring caused a significant inhibition against expression of the iNOS2 in LPS-induced macrophages. In addition, cytotoxic assay displayed most derivatives have good safety in vitro. This new promising scaffold could be further exploited for the development of anti-inflammatory agent in the future." @default.
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- W2807328311 date "2018-09-01" @default.
- W2807328311 modified "2023-09-24" @default.
- W2807328311 title "Design, synthesis, and anti-inflammatory activity of caffeoyl salicylate analogs as NO production inhibitors" @default.
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- W2807328311 doi "https://doi.org/10.1016/j.fitote.2018.05.029" @default.
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