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• W2807328497 abstract "Abstract The wap gene encodes a single whey acidic protein (WAP) domain-containing peptide from Chinese white shrimp ( Fenneropenaeus chinensis ), which shows broad-spectrum antimicrobial activities and proteinase inhibitory activities in vitro . To explore the medical applications of the WAP peptide, a wap gene transgenic Drosophila melanogaster was constructed. In wap -expressing flies, high expression levels of wap gene (>100 times) were achieved, in contrast to those of control flies, by qRT-PCR analysis. The wap gene expression was associated with increased resistance to microbial infection and decreased bacterial numbers in the flies. In addition, the WAP protein extract from wap -expressing flies, compared with control protein extract from control flies, showed improved antimicrobial activities against broad Gram-positive and Gram-negative bacteria, including the clinical drug resistant bacterium of methicillin-resistant S . aureus ( MRSA ), improved protease inhibitor activities against crude proteinases and commercial proteinases, including elastase, subtilis proteinase A, and proteinase K in vitro , and improved growth rate and microbial resistance, as well as wound-healing in loach and mouse models. These results suggest that wap -expressing flies could be used as a food additive in aquaculture to prevent infections and a potential antibacterial for fighting drug-resistant bacteria." @default.
• W2807328497 created "2018-06-13" @default.
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• W2807328497 date "2018-06-08" @default.
• W2807328497 modified "2023-10-12" @default.
• W2807328497 title "Expression of the Shrimp wap gene in Drosophila elicits defense responses and protease inhibitory activity" @default.
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• W2807328497 doi "https://doi.org/10.1038/s41598-018-26466-6" @default.
• W2807328497 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5993750" @default.
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• W2807328497 hasPublicationYear "2018" @default.
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