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- W2807333499 abstract "Abstract A subset of human follicular helper T cells (TFH) cells expresses CD57 for which no distinct function has been identified. We show that CD57+ TFH cells are universally PD-1 hi , but compared to their CD57− PD-1 hi counterparts, express little IL-21 or IL-10 among others. Instead, CD57 expression on TFH cells marks cytotoxicity transcriptional signatures that translate into only a weak cytotoxic phenotype. Similarly, circulating PD-1+ CD57+ CD4+ T cells make less cytokine than their CD57− PD-1+ counterparts, but have a prominent cytotoxic phenotype. By analysis of responses to STAT3-dependent cytokines and cells from patients with gain- or loss-of-function STAT3 mutations, we show that CD4+ T cell cytotoxicity is STAT3-dependent. TFH formation also requires STAT3, but paradoxically, once formed, PD-1 hi cells become unresponsive to STAT3. These findings suggest that changes in blood and germinal center cytotoxicity might be affected by changes in STAT3 signaling, or modulation of PD-1 by therapy." @default.
- W2807333499 created "2018-06-13" @default.
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- W2807333499 date "2018-02-23" @default.
- W2807333499 modified "2023-10-18" @default.
- W2807333499 title "STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles" @default.
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- W2807333499 doi "https://doi.org/10.1038/s41598-018-21389-8" @default.
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