Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807345247> ?p ?o ?g. }
- W2807345247 abstract "Abstract Human Cytomegalovirus (HCMV) remains a major health burden and the development of a vaccine is a global priority. We developed new viral vectors delivering the T cell immunogens IE-1 and pp65 based on Adenovirus 19a/64 (Ad19a/64), a member of subgroup D. In this ex vivo study, the novel vectors were compared side by side to Ad5 or modified Vaccinia Ankara (MVA) strains expressing the same transgenes. We found that unlike Ad5, Ad19a/64 vectors readily transduce a broad panel of immune cells, including monocytes, T cells, NK cells and monocyte-derived dendritic cells (moDCs). Both Ad19a/64- and MVA-transduced moDCs efficiently restimulated IE-1 or pp65-specific T cells but MVA induced a higher amount of cytotoxicity in this cell type. Ad5 and Ad19 induced upregulation of CD86 and HLA-DR in moDCs whereas expression of CD80 and CD83 was largely unaltered. By contrast, MVA transduction led to downregulation of all markers. Taken together, our data demonstrate that Ad19a/64 is a promising vector for the delivery of HCMV immunogens since it transduces dendritic cells with an efficiency that is comparable to MVA, but cytotoxicity and interference with dendritic cell maturation are less pronounced." @default.
- W2807345247 created "2018-06-13" @default.
- W2807345247 creator A5002707326 @default.
- W2807345247 creator A5012934361 @default.
- W2807345247 creator A5020871813 @default.
- W2807345247 creator A5036809091 @default.
- W2807345247 creator A5038015992 @default.
- W2807345247 creator A5074021024 @default.
- W2807345247 creator A5082600296 @default.
- W2807345247 creator A5086602628 @default.
- W2807345247 date "2018-01-24" @default.
- W2807345247 modified "2023-10-10" @default.
- W2807345247 title "Vaccine vectors based on Adenovirus 19a/64 exhibit broad cellular tropism and potently restimulate HCMV-specific T cell responses ex vivo" @default.
- W2807345247 cites W1564846515 @default.
- W2807345247 cites W1880910574 @default.
- W2807345247 cites W1899078957 @default.
- W2807345247 cites W1968487372 @default.
- W2807345247 cites W1971656628 @default.
- W2807345247 cites W1972244141 @default.
- W2807345247 cites W1981144987 @default.
- W2807345247 cites W1982712041 @default.
- W2807345247 cites W1984402213 @default.
- W2807345247 cites W1986509391 @default.
- W2807345247 cites W1987723433 @default.
- W2807345247 cites W1996322297 @default.
- W2807345247 cites W1999417281 @default.
- W2807345247 cites W2005802185 @default.
- W2807345247 cites W2006695397 @default.
- W2807345247 cites W2015108596 @default.
- W2807345247 cites W2019921823 @default.
- W2807345247 cites W2020929096 @default.
- W2807345247 cites W2024505394 @default.
- W2807345247 cites W2044254174 @default.
- W2807345247 cites W2051758487 @default.
- W2807345247 cites W2063949074 @default.
- W2807345247 cites W2065903458 @default.
- W2807345247 cites W2079852426 @default.
- W2807345247 cites W2096728165 @default.
- W2807345247 cites W2103849595 @default.
- W2807345247 cites W2104800327 @default.
- W2807345247 cites W2105981547 @default.
- W2807345247 cites W2111851565 @default.
- W2807345247 cites W2117806504 @default.
- W2807345247 cites W2119627739 @default.
- W2807345247 cites W2121049053 @default.
- W2807345247 cites W2126697685 @default.
- W2807345247 cites W2133957204 @default.
- W2807345247 cites W2136875106 @default.
- W2807345247 cites W2142161841 @default.
- W2807345247 cites W2142902077 @default.
- W2807345247 cites W2145923451 @default.
- W2807345247 cites W2146108709 @default.
- W2807345247 cites W2149322899 @default.
- W2807345247 cites W2153670011 @default.
- W2807345247 cites W2155802193 @default.
- W2807345247 cites W2172039135 @default.
- W2807345247 cites W2174852485 @default.
- W2807345247 cites W2177829601 @default.
- W2807345247 cites W2247920240 @default.
- W2807345247 cites W2282367051 @default.
- W2807345247 cites W2342023283 @default.
- W2807345247 cites W2343060625 @default.
- W2807345247 cites W2415842603 @default.
- W2807345247 cites W2539103046 @default.
- W2807345247 cites W2539609404 @default.
- W2807345247 cites W2563710553 @default.
- W2807345247 cites W2606625852 @default.
- W2807345247 cites W3123411076 @default.
- W2807345247 cites W4255472470 @default.
- W2807345247 doi "https://doi.org/10.1038/s41598-018-19874-1" @default.
- W2807345247 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5784015" @default.
- W2807345247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29367743" @default.
- W2807345247 hasPublicationYear "2018" @default.
- W2807345247 type Work @default.
- W2807345247 sameAs 2807345247 @default.
- W2807345247 citedByCount "5" @default.
- W2807345247 countsByYear W28073452472018 @default.
- W2807345247 countsByYear W28073452472020 @default.
- W2807345247 countsByYear W28073452472021 @default.
- W2807345247 countsByYear W28073452472022 @default.
- W2807345247 crossrefType "journal-article" @default.
- W2807345247 hasAuthorship W2807345247A5002707326 @default.
- W2807345247 hasAuthorship W2807345247A5012934361 @default.
- W2807345247 hasAuthorship W2807345247A5020871813 @default.
- W2807345247 hasAuthorship W2807345247A5036809091 @default.
- W2807345247 hasAuthorship W2807345247A5038015992 @default.
- W2807345247 hasAuthorship W2807345247A5074021024 @default.
- W2807345247 hasAuthorship W2807345247A5082600296 @default.
- W2807345247 hasAuthorship W2807345247A5086602628 @default.
- W2807345247 hasBestOaLocation W28073452471 @default.
- W2807345247 hasConcept C104317684 @default.
- W2807345247 hasConcept C150903083 @default.
- W2807345247 hasConcept C154317977 @default.
- W2807345247 hasConcept C159047783 @default.
- W2807345247 hasConcept C202751555 @default.
- W2807345247 hasConcept C203014093 @default.
- W2807345247 hasConcept C207001950 @default.
- W2807345247 hasConcept C26291073 @default.
- W2807345247 hasConcept C2776090121 @default.
- W2807345247 hasConcept C2778170410 @default.