Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807345369> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2807345369 endingPage "67" @default.
- W2807345369 startingPage "52" @default.
- W2807345369 abstract "The review presents statistics of published randomized phase III trials on the addition of hyperthermia (HT) to other cancer therapies, and analyzes the results of these trials. In total, 47 comparisons could be made for treatments with or without HT. These trials were done in a large variety of solid tumors, and in centers in Asia, Europe, North America and Australia. In general, these studies were relatively small – 17 studies included more than 100 patients. The total number of patients was 5099. In the majority of the studies, HT was applied with electromagnetic radiation. Most studies (74 %) have shown that additional HT significantly improves the results of radiation, chemo- and chemoradiotherapy in patients with, in general, locally advanced relapsed and metastatic forms of malignant tumors. Improved results were reported for complete and overall response, loco-regional tumor control, disease free and overall survival, and, in one study, for palliative effects. In these randomized trials also acute and/or late toxicity has been investigated. In the majority of the trials, addition of HT did not result in significant increases of toxic effects. The economic consequences of HT as part of cancer treatment are discussed. Twenty-six percent of the studies failed to show a significant beneficial effect of HT which are discussed in more detail. In 4 studies with a trend of a better outcome in the plus HT treatment arm, with an absolute difference of 10 % or more, the lack of significance is probably due to a low number of patients included. In other studies, there was an unbalanced distribution of tumor characteristics over the two study arms, with worse prognostic factors in the plus HT arm, inadequate techniques, using too high frequency of electromagnetic radiation, and/or a small applicator, and/or a short heating time, so that a sufficient energy deposition in the tumor volume could not be achieved. These results make clear that it is important to develop guidelines for the application of HT, in addition to the existing ones. In view of the different principles of operation of HT applicators, it is important that such guidelines will become available for each individual device. Further, it is important to conduct larger randomized trials. Larger studies would probably increase the number of significant and also more relevant outcomes, and promote a wider acceptance of HT as part of cancer treatment." @default.
- W2807345369 created "2018-06-13" @default.
- W2807345369 creator A5068112534 @default.
- W2807345369 creator A5054425573 @default.
- W2807345369 date "2018-06-06" @default.
- W2807345369 modified "2023-09-25" @default.
- W2807345369 title "Results of Randomized Studies on Hyperthermia in Oncology" @default.
- W2807345369 cites W1132821361 @default.
- W2807345369 cites W1911698430 @default.
- W2807345369 cites W1982507764 @default.
- W2807345369 cites W1990575635 @default.
- W2807345369 cites W2027633833 @default.
- W2807345369 cites W2083184030 @default.
- W2807345369 cites W2091134247 @default.
- W2807345369 cites W2102649918 @default.
- W2807345369 cites W2128668604 @default.
- W2807345369 cites W2143321353 @default.
- W2807345369 cites W2143773781 @default.
- W2807345369 cites W2174141209 @default.
- W2807345369 cites W2274415893 @default.
- W2807345369 cites W2337122080 @default.
- W2807345369 cites W4252825146 @default.
- W2807345369 doi "https://doi.org/10.12737/article_5b179d60437d54.24079640" @default.
- W2807345369 hasPublicationYear "2018" @default.
- W2807345369 type Work @default.
- W2807345369 sameAs 2807345369 @default.
- W2807345369 citedByCount "3" @default.
- W2807345369 countsByYear W28073453692019 @default.
- W2807345369 countsByYear W28073453692020 @default.
- W2807345369 countsByYear W28073453692021 @default.
- W2807345369 crossrefType "journal-article" @default.
- W2807345369 hasAuthorship W2807345369A5054425573 @default.
- W2807345369 hasAuthorship W2807345369A5068112534 @default.
- W2807345369 hasConcept C121608353 @default.
- W2807345369 hasConcept C126322002 @default.
- W2807345369 hasConcept C141071460 @default.
- W2807345369 hasConcept C143998085 @default.
- W2807345369 hasConcept C168563851 @default.
- W2807345369 hasConcept C2779134260 @default.
- W2807345369 hasConcept C2779949491 @default.
- W2807345369 hasConcept C509974204 @default.
- W2807345369 hasConcept C535046627 @default.
- W2807345369 hasConcept C71924100 @default.
- W2807345369 hasConceptScore W2807345369C121608353 @default.
- W2807345369 hasConceptScore W2807345369C126322002 @default.
- W2807345369 hasConceptScore W2807345369C141071460 @default.
- W2807345369 hasConceptScore W2807345369C143998085 @default.
- W2807345369 hasConceptScore W2807345369C168563851 @default.
- W2807345369 hasConceptScore W2807345369C2779134260 @default.
- W2807345369 hasConceptScore W2807345369C2779949491 @default.
- W2807345369 hasConceptScore W2807345369C509974204 @default.
- W2807345369 hasConceptScore W2807345369C535046627 @default.
- W2807345369 hasConceptScore W2807345369C71924100 @default.
- W2807345369 hasLocation W28073453691 @default.
- W2807345369 hasOpenAccess W2807345369 @default.
- W2807345369 hasPrimaryLocation W28073453691 @default.
- W2807345369 hasRelatedWork W1596203804 @default.
- W2807345369 hasRelatedWork W1998925912 @default.
- W2807345369 hasRelatedWork W2007273136 @default.
- W2807345369 hasRelatedWork W2032525847 @default.
- W2807345369 hasRelatedWork W2033238073 @default.
- W2807345369 hasRelatedWork W2043677478 @default.
- W2807345369 hasRelatedWork W2073849682 @default.
- W2807345369 hasRelatedWork W2092201775 @default.
- W2807345369 hasRelatedWork W2125395847 @default.
- W2807345369 hasRelatedWork W2143774419 @default.
- W2807345369 hasRelatedWork W2144090480 @default.
- W2807345369 hasRelatedWork W2239056549 @default.
- W2807345369 hasRelatedWork W2408640453 @default.
- W2807345369 hasRelatedWork W2409114483 @default.
- W2807345369 hasRelatedWork W2413483612 @default.
- W2807345369 hasRelatedWork W2419258667 @default.
- W2807345369 hasRelatedWork W2422903432 @default.
- W2807345369 hasRelatedWork W2468049807 @default.
- W2807345369 hasRelatedWork W2511590483 @default.
- W2807345369 hasRelatedWork W2775307099 @default.
- W2807345369 isParatext "false" @default.
- W2807345369 isRetracted "false" @default.
- W2807345369 magId "2807345369" @default.
- W2807345369 workType "article" @default.