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- W280734551 abstract "Pediatric malignancies in adults, in contrast to the same diseases in children are clinically more aggressive, resistant to chemotherapeutics, and carry a higher risk of relapse. Molecular profiling of tumor sample using next generation sequencing (NGS) has recently become clinically available. We report the results of targeted exome sequencing of six adult patients with pediatric-type malignancies : Wilms tumor(n=2), medulloblastoma(n=2), Ewing's sarcoma( n=1) and desmoplastic small round cell tumor (n=1) with a median age of 28.8 years. Detection of druggable somatic aberrations in tumors is feasible. However, identification of actionable target therapies in these rare adult patients with pediatric-type malignancies is challenging. Continuous efforts to establish a rare disease registry are warranted." @default.
- W280734551 created "2016-06-24" @default.
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- W280734551 date "2015-02-20" @default.
- W280734551 modified "2023-10-18" @default.
- W280734551 title "Clinical next generation sequencing of pediatric-type malignancies in adult patients identifies novel somatic aberrations" @default.
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- W280734551 doi "https://doi.org/10.18632/oncoscience.131" @default.
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