FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807369598> ?p ?o ?g. }

• W2807369598 abstract "Clinical data and experimental studies have suggested a relationship between psychosocial factors and cancer prognosis. Both, stress effects on the immune system and on tumor biology were analyzed independently. However, there are few studies regarding the stress influence on the interplay between the immune system and tumor biology. Moreover, antidepressants have been used in patients with cancer to alleviate mood disorders. Nevertheless, there is contradictory evidence about their action on cancer prognosis. In this context, we investigated the effect of chronic stress on tumor progression taking into account both its influence on the immune system and on tumor biology. Furthermore, we analyzed the action of selective serotonin reuptake inhibitors, fluoxetine and sertraline, in these effects. For this purpose, C57BL/6J mice submitted or not to a chronic stress model and treated or not with fluoxetine or sertraline were subcutaneously inoculated with EL4 cells to develop solid tumors. Our results indicated that chronic stress leads to an increase in both tumor growth and tumor cell dissemination. The analysis of cell cycle regulatory proteins showed that stress induced an increase in the mRNA levels of cyclins A2, D1, and D3 and a decrease in mRNA levels of cell cycle inhibitors p15, p16, p21, p27, stimulating cell cycle progression. Moreover, an augment of mRNA levels of metalloproteases (MMP-2 and MMP-9), a decrease of inhibitors of metalloproteases mRNA levels (TIMP 1, 2, and 3), and an increase in migration ability were found in tumors from stressed animals. In addition, a significant decrease of antitumor immune response in animals under stress was found. Adoptive lymphoid cell transfer experiments indicated that the reduced immune response in stressed animals influenced both the tumor growth and the metastatic capacity of tumor cells. Finally, we found an important beneficious effect of fluoxetine or sertraline treatment on cancer progression. Our results emphasize the crucial role of the immune system in tumor progression under stress situations. Although a direct effect of stress and drug treatment on tumor biology could not be ruled out, the beneficial effect of fluoxetine and sertraline appears to be mainly due to a restoration of antitumor immune response." @default.
• W2807369598 created "2018-06-13" @default.
• W2807369598 creator A5007582060 @default.
• W2807369598 creator A5063917386 @default.
• W2807369598 creator A5066083078 @default.
• W2807369598 creator A5088929599 @default.
• W2807369598 date "2018-06-19" @default.
• W2807369598 modified "2023-10-09" @default.
• W2807369598 title "Beneficial Effect of Fluoxetine and Sertraline on Chronic Stress-Induced Tumor Growth and Cell Dissemination in a Mouse Model of Lymphoma: Crucial Role of Antitumor Immunity" @default.
• W2807369598 cites W1483194800 @default.
• W2807369598 cites W1505106878 @default.
• W2807369598 cites W1521227887 @default.
• W2807369598 cites W1561772418 @default.
• W2807369598 cites W1587592647 @default.
• W2807369598 cites W1744046449 @default.
• W2807369598 cites W1925895851 @default.
• W2807369598 cites W1959055352 @default.
• W2807369598 cites W1963535284 @default.
• W2807369598 cites W1966369019 @default.
• W2807369598 cites W1969412681 @default.
• W2807369598 cites W1971620413 @default.
• W2807369598 cites W1971773966 @default.
• W2807369598 cites W1982314007 @default.
• W2807369598 cites W1988406366 @default.
• W2807369598 cites W1989327363 @default.
• W2807369598 cites W1996667083 @default.
• W2807369598 cites W2000040971 @default.
• W2807369598 cites W2016570620 @default.
• W2807369598 cites W2019214729 @default.
• W2807369598 cites W2021102872 @default.
• W2807369598 cites W2021880490 @default.
• W2807369598 cites W2023118924 @default.
• W2807369598 cites W2023531182 @default.
• W2807369598 cites W2025845020 @default.
• W2807369598 cites W2031937031 @default.
• W2807369598 cites W2033893046 @default.
• W2807369598 cites W2048294916 @default.
• W2807369598 cites W2048759192 @default.
• W2807369598 cites W2055716589 @default.
• W2807369598 cites W2062650567 @default.
• W2807369598 cites W2074153097 @default.
• W2807369598 cites W2075115877 @default.
• W2807369598 cites W2080454733 @default.
• W2807369598 cites W2081547493 @default.
• W2807369598 cites W2083685105 @default.
• W2807369598 cites W2084235593 @default.
• W2807369598 cites W2084604753 @default.
• W2807369598 cites W2085177979 @default.
• W2807369598 cites W2085562315 @default.
• W2807369598 cites W2091495358 @default.
• W2807369598 cites W2092743430 @default.
• W2807369598 cites W2095612053 @default.
• W2807369598 cites W2097385775 @default.
• W2807369598 cites W2107277218 @default.
• W2807369598 cites W2107567947 @default.
• W2807369598 cites W2131832357 @default.
• W2807369598 cites W2135459104 @default.
• W2807369598 cites W2141382054 @default.
• W2807369598 cites W2151356556 @default.
• W2807369598 cites W2156899696 @default.
• W2807369598 cites W2159422800 @default.
• W2807369598 cites W2161937654 @default.
• W2807369598 cites W2166764399 @default.
• W2807369598 cites W2175707649 @default.
• W2807369598 cites W2182712890 @default.
• W2807369598 cites W2189058844 @default.
• W2807369598 cites W2192080449 @default.
• W2807369598 cites W2268255714 @default.
• W2807369598 cites W2269307100 @default.
• W2807369598 cites W2413443909 @default.
• W2807369598 cites W2414890496 @default.
• W2807369598 cites W2460544034 @default.
• W2807369598 cites W2470177655 @default.
• W2807369598 cites W2493892601 @default.
• W2807369598 cites W2515903967 @default.
• W2807369598 cites W2573086553 @default.
• W2807369598 cites W2585561618 @default.
• W2807369598 cites W2608386405 @default.
• W2807369598 cites W2649656222 @default.
• W2807369598 cites W2766762285 @default.
• W2807369598 cites W339478007 @default.
• W2807369598 cites W4239288354 @default.
• W2807369598 cites W50465896 @default.
• W2807369598 cites W2183541497 @default.
• W2807369598 doi "https://doi.org/10.3389/fimmu.2018.01341" @default.
• W2807369598 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6018164" @default.
• W2807369598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29971064" @default.
• W2807369598 hasPublicationYear "2018" @default.
• W2807369598 type Work @default.
• W2807369598 sameAs 2807369598 @default.
• W2807369598 citedByCount "28" @default.
• W2807369598 countsByYear W28073695982019 @default.
• W2807369598 countsByYear W28073695982020 @default.
• W2807369598 countsByYear W28073695982021 @default.
• W2807369598 countsByYear W28073695982022 @default.
• W2807369598 countsByYear W28073695982023 @default.
• W2807369598 crossrefType "journal-article" @default.
• W2807369598 hasAuthorship W2807369598A5007582060 @default.
• W2807369598 hasAuthorship W2807369598A5063917386 @default.
• W2807369598 hasAuthorship W2807369598A5066083078 @default.

• next