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- W280737272 abstract "Objective:To investigate gene profile in diabetic liver tissue and perform metabolic pathway analysis among significantly increased or decreased expression gene.Methods: OLigonucleotide array was utilized to screen the defference of gene expression in both diabetic liver and normal liver tissue.KEGG metabolic pathway was performed among significantly increased or decreased gene.RT-PCR was performed to assessthe mRNA level of the gene.Results: Compare with the matched normal tissue,492 genes was upregulated and 820 genes was downregulated in the diabetic liver.Among the first 20 difference gene,they are involved in oxidative stress,immune and inflammation response and lipid metabolism.KEGG metabolic pathway analysis showed that gene profile of diabetic liver was in accordance with pathway change in type 2 diabetes.Signficantly difference gene was involved in the metabolic pathway such as insulin signaling pathway,complement and coagulation cascades,fructose and mannose,adherens junction,pentose phosphate pathway,lipid metabolism,cytokine and cytokine-receptor interaction.SOD2 mRNA and CRPmRNA was signficanly more upregulated in diabetic liver than in nomal control proved by RT-PCR.Conclution: The change of gene profile was involved in the metabolic pathway such as insulin signaling pathway,complement and coagulation cascades,fructose and mannose,adherens junction,pentose phosphate pathway,lipid metabolism,the role of liver in the pathogenesis may involved in the change of insulin signal pathway,carbohydrate metabolism and lipid metabolism." @default.
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- W280737272 date "2009-01-01" @default.
- W280737272 modified "2023-09-27" @default.
- W280737272 title "Metabolic pathway analysis on gene profiling of diabetic liver." @default.
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