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- W2807378324 abstract "Cytomegalovirus (CMV) has a high prevalence worldwide, is often fatal for immunocompromised patients, and causes bone marrow suppression. Deficiency of signal transducer and activator of transcription 1 (STAT1) results in severely impaired antiviral immunity. We have used cell-type restricted deletion of Stat1 to determine the importance of myeloid cell activity for the defense against murine CMV (MCMV). We show that myeloid STAT1 limits MCMV burden and infection-associated pathology in the spleen but does not affect ultimate clearance of infection. Unexpectedly, we found an essential role of myeloid STAT1 in the induction of extramedullary hematopoiesis (EMH). The EMH-promoting function of STAT1 was not restricted to MCMV infection but was also observed during CpG oligodeoxynucleotide-induced sterile inflammation. Collectively, we provide genetic evidence that signaling through STAT1 in myeloid cells is required to restrict MCMV at early time points post-infection and to induce compensatory hematopoiesis in the spleen." @default.
- W2807378324 created "2018-06-13" @default.
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- W2807378324 date "2019-02-01" @default.
- W2807378324 modified "2023-10-15" @default.
- W2807378324 title "Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1" @default.
- W2807378324 cites W1042752253 @default.
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- W2807378324 cites W1570398595 @default.
- W2807378324 cites W1595293335 @default.
- W2807378324 cites W1662539477 @default.
- W2807378324 cites W1731125787 @default.
- W2807378324 cites W1787222452 @default.
- W2807378324 cites W1868950919 @default.
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- W2807378324 cites W1963136563 @default.
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- W2807378324 cites W1968028452 @default.
- W2807378324 cites W1969633526 @default.
- W2807378324 cites W1972610636 @default.
- W2807378324 cites W1980096748 @default.
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- W2807378324 cites W2005543635 @default.
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- W2807378324 cites W2009414050 @default.
- W2807378324 cites W2011059916 @default.
- W2807378324 cites W2012029948 @default.
- W2807378324 cites W2014984472 @default.
- W2807378324 cites W2018642899 @default.
- W2807378324 cites W2019009873 @default.
- W2807378324 cites W2023543357 @default.
- W2807378324 cites W2028978159 @default.
- W2807378324 cites W2031208709 @default.
- W2807378324 cites W2034075280 @default.
- W2807378324 cites W2039823694 @default.
- W2807378324 cites W2047879222 @default.
- W2807378324 cites W2047882003 @default.
- W2807378324 cites W2048719634 @default.
- W2807378324 cites W2050676604 @default.
- W2807378324 cites W2052904272 @default.
- W2807378324 cites W2058593952 @default.
- W2807378324 cites W2062879350 @default.
- W2807378324 cites W2063892379 @default.
- W2807378324 cites W2066005598 @default.
- W2807378324 cites W2069877187 @default.
- W2807378324 cites W2072411272 @default.
- W2807378324 cites W2078381704 @default.
- W2807378324 cites W2079014709 @default.
- W2807378324 cites W2079357798 @default.
- W2807378324 cites W2088992300 @default.
- W2807378324 cites W2095498551 @default.
- W2807378324 cites W2098187991 @default.
- W2807378324 cites W2099516146 @default.
- W2807378324 cites W2106915396 @default.
- W2807378324 cites W2107179964 @default.
- W2807378324 cites W2115027745 @default.
- W2807378324 cites W2116011212 @default.
- W2807378324 cites W2122281775 @default.
- W2807378324 cites W2122506044 @default.
- W2807378324 cites W2125128634 @default.
- W2807378324 cites W2131480973 @default.
- W2807378324 cites W2131777296 @default.
- W2807378324 cites W2134539007 @default.
- W2807378324 cites W2137949504 @default.
- W2807378324 cites W2138355969 @default.
- W2807378324 cites W2142903473 @default.
- W2807378324 cites W2143112229 @default.