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- W2807382073 abstract "Docosahexaenoic acid (DHA) and neuroprotectin D1 (NPD1) are neuroprotective after experimental ischemic stroke. To explore underlying mechanisms, SD rats underwent 2 h of middle cerebral artery occlusion (MCAo) and treated with DHA (5 mg/kg, IV) or NPD1 (5 μg/per rat, ICV) and vehicles 1 h after. Neuro-behavioral assessments was conducted on days 1, 2, and 3, and on week 1, 2, 3, or 4. BrdU was injected on days 4, 5, and 6, immunohistochemistry was performed on week 2 or 4, MRI on day 7, and lipidomic analysis at 4 and 5 h after onset of stroke. DHA improved short- and long-term behavioral functions and reduced cortical, subcortical, and total infarct volumes (by 42, 47, and 31%, respectively) after 2 weeks and reduced tissue loss by 50% after 4 weeks. DHA increased the number of BrdU+/Ki-67+, BrdU+/DCX+, and BrdU+/NeuN+ cells in the cortex, subventricular zone, and dentate gyrus and potentiated NPD1 synthesis in the penumbra at 5 h after MCAo. NPD1 improved behavior, reduced lesion volumes, protected ischemic penumbra, increased NeuN, GFAP, SMI-71-positive cells and vessels, axonal regeneration in the penumbra, and attenuated blood-brain barrier (BBB) after MCAo. We conclude that docosanoid administration increases neurogenesis and angiogenesis, activates NPD1 synthesis in the penumbra, and diminishes BBB permeability, which correlates to long-term neurobehavioral recovery after experimental ischemic stroke." @default.
- W2807382073 created "2018-06-13" @default.
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- W2807382073 date "2018-06-01" @default.
- W2807382073 modified "2023-10-14" @default.
- W2807382073 title "Docosanoids Promote Neurogenesis and Angiogenesis, Blood-Brain Barrier Integrity, Penumbra Protection, and Neurobehavioral Recovery After Experimental Ischemic Stroke" @default.
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- W2807382073 cites W1963940970 @default.
- W2807382073 cites W1966315067 @default.
- W2807382073 cites W1969871031 @default.
- W2807382073 cites W1977416216 @default.
- W2807382073 cites W1992122074 @default.
- W2807382073 cites W2000144593 @default.
- W2807382073 cites W2009117300 @default.
- W2807382073 cites W2009718837 @default.
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- W2807382073 cites W2022785786 @default.
- W2807382073 cites W2023799799 @default.
- W2807382073 cites W2026281867 @default.
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- W2807382073 cites W2030887667 @default.
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- W2807382073 cites W2044264673 @default.
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- W2807382073 cites W2048661776 @default.
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- W2807382073 doi "https://doi.org/10.1007/s12035-018-1136-3" @default.
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