FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807407838> ?p ?o ?g. }

• W2807407838 endingPage "e240" @default.
• W2807407838 startingPage "e240" @default.
• W2807407838 abstract "Objective: There are differences in the development of diabetic nephropathy (DN) between men and women but the molecular mechanisms underlying these are incompletely understood. The urinary proteome may contain sex-specific biomarkers and thereby highlight differentially regulated mechanisms leading to DN in men and women. Design and method: Urine samples were obtained from 157 patients with type 2 diabetes (age, 61 [29–71] years; 120 men and 37 women), preserved renal function (eGFR, 88 ± 17 mL/min) and confirmed microalbuminuria (UAER, 85 [34;194] mg/d). Peptidomic analysis was undertaken using capillary electrophoresis coupled to mass spectrometry. We compared individual urinary peptides between men and women. Results: We detected a total of 4914 individual peptides in at least one participant. Sex-specific differences were seen in expression of 343 peptides (Chi squared, P < 0.05) with 86 and 257 peptides being more common in men and women, respectively. We then performed quantitative analysis of the abundance of 196 peptides that were found in at least 25% of male or female subjects and were more frequent compared to the other sex. Of these, 165 peptides were significantly (Mann-Whitney U-test, P < 0.05) differently expressed in urine. Sex remained the strongest determinant of these peptides’ abundance after adjustment for age, eGFR and urinary albumin excretion. In men, presence of Peptide 186095 was associated with lower levels of UAER (P < 0.001), and in women this was the case for Peptide 187114 (P = 0.024). Of the 196 peptides with significant sex-specific regulation, 25 are also components of the CKD273 peptidomic panel for prediction of DN. Conclusions: Out of 4914 urinary peptides 196 exhibit sex-specific regulation in a cohort of patients at early stage of DN. Biological activity and predictive value of these peptides are currently unknown. The majority of peptides within the CKD273 classifier are not sex-specific. CKD273 is therefore a robust biomarker in both men and women but probably less ideally suited to dissect sex differences in the initiation and progression of DN. Larger datasets will have to be explored to confirm these results and to investigate whether sex-specific regulation of urinary peptides explains differences in DN progression between men and women." @default.
• W2807407838 created "2018-06-13" @default.
• W2807407838 creator A5012676820 @default.
• W2807407838 creator A5018317149 @default.
• W2807407838 creator A5026550515 @default.
• W2807407838 creator A5040449404 @default.
• W2807407838 creator A5042966344 @default.
• W2807407838 creator A5044496367 @default.
• W2807407838 creator A5051510895 @default.
• W2807407838 creator A5052560289 @default.
• W2807407838 creator A5070650168 @default.
• W2807407838 creator A5083703658 @default.
• W2807407838 date "2018-06-01" @default.
• W2807407838 modified "2023-10-16" @default.
• W2807407838 title "SEX-SPECIFIC REGULATION OF URINARY PEPTIDES IN EARLY DIABETIC NEPHROPTHY" @default.
• W2807407838 doi "https://doi.org/10.1097/01.hjh.0000539675.87970.2e" @default.
• W2807407838 hasPublicationYear "2018" @default.
• W2807407838 type Work @default.
• W2807407838 sameAs 2807407838 @default.
• W2807407838 citedByCount "0" @default.
• W2807407838 crossrefType "journal-article" @default.
• W2807407838 hasAuthorship W2807407838A5012676820 @default.
• W2807407838 hasAuthorship W2807407838A5018317149 @default.
• W2807407838 hasAuthorship W2807407838A5026550515 @default.
• W2807407838 hasAuthorship W2807407838A5040449404 @default.
• W2807407838 hasAuthorship W2807407838A5042966344 @default.
• W2807407838 hasAuthorship W2807407838A5044496367 @default.
• W2807407838 hasAuthorship W2807407838A5051510895 @default.
• W2807407838 hasAuthorship W2807407838A5052560289 @default.
• W2807407838 hasAuthorship W2807407838A5070650168 @default.
• W2807407838 hasAuthorship W2807407838A5083703658 @default.
• W2807407838 hasConcept C104397665 @default.
• W2807407838 hasConcept C126322002 @default.
• W2807407838 hasConcept C134018914 @default.
• W2807407838 hasConcept C159641895 @default.
• W2807407838 hasConcept C2776174234 @default.
• W2807407838 hasConcept C2779922275 @default.
• W2807407838 hasConcept C2780026642 @default.
• W2807407838 hasConcept C2781203188 @default.
• W2807407838 hasConcept C555293320 @default.
• W2807407838 hasConcept C60644358 @default.
• W2807407838 hasConcept C71924100 @default.
• W2807407838 hasConcept C77411442 @default.
• W2807407838 hasConcept C86803240 @default.
• W2807407838 hasConceptScore W2807407838C104397665 @default.
• W2807407838 hasConceptScore W2807407838C126322002 @default.
• W2807407838 hasConceptScore W2807407838C134018914 @default.
• W2807407838 hasConceptScore W2807407838C159641895 @default.
• W2807407838 hasConceptScore W2807407838C2776174234 @default.
• W2807407838 hasConceptScore W2807407838C2779922275 @default.
• W2807407838 hasConceptScore W2807407838C2780026642 @default.
• W2807407838 hasConceptScore W2807407838C2781203188 @default.
• W2807407838 hasConceptScore W2807407838C555293320 @default.
• W2807407838 hasConceptScore W2807407838C60644358 @default.
• W2807407838 hasConceptScore W2807407838C71924100 @default.
• W2807407838 hasConceptScore W2807407838C77411442 @default.
• W2807407838 hasConceptScore W2807407838C86803240 @default.
• W2807407838 hasIssue "Supplement 1" @default.
• W2807407838 hasLocation W28074078381 @default.
• W2807407838 hasOpenAccess W2807407838 @default.
• W2807407838 hasPrimaryLocation W28074078381 @default.
• W2807407838 hasRelatedWork W2028392107 @default.
• W2807407838 hasRelatedWork W2131561025 @default.
• W2807407838 hasRelatedWork W2368320898 @default.
• W2807407838 hasRelatedWork W2372807633 @default.
• W2807407838 hasRelatedWork W2376102491 @default.
• W2807407838 hasRelatedWork W2378708071 @default.
• W2807407838 hasRelatedWork W2388788505 @default.
• W2807407838 hasRelatedWork W2792968499 @default.
• W2807407838 hasRelatedWork W3106199766 @default.
• W2807407838 hasRelatedWork W3211429712 @default.
• W2807407838 hasVolume "36" @default.
• W2807407838 isParatext "false" @default.
• W2807407838 isRetracted "false" @default.
• W2807407838 magId "2807407838" @default.
• W2807407838 workType "article" @default.