FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807451608> ?p ?o ?g. }

• W2807451608 endingPage "2450" @default.
• W2807451608 startingPage "2439" @default.
• W2807451608 abstract "Nodular basal cell carcinoma is a deep skin lesion and one of the most common cancers. Conventional photodynamic therapy is limited to treatment of superficial skin lesions. The parenteral administration of near-IR preformed photosensitizers suffers from poor selectivity and may result in prolonged skin photosensitivity. Microneedles (MNs) can provide localized drug delivery to skin lesions. Intradermal delivery of the preformed near-IR photosensitizer; 5,10,15,20-tetrakis(2,6-difluoro-3-N-methylsulfamoylphenyl bacteriochlorin (Redaporfin™) using dissolving MN was successful in vitro and in vivo. MN demonstrated complete dissolution 30 min after skin application and showed sufficient mechanical strength to penetrate the skin to a depth of 450 μm. In vitro deposition studies illustrated that the drug was delivered and detected down to 5 mm in skin. In vivo biodistribution studies in athymic nude mice Crl:NU(NCr)-Foxn1nu showed both fast initial release and localized drug delivery. The MN-treated mice showed a progressive decrease in the fluorescence intensity at the application site over the 7-day experiment period, with the highest and lowest fluorescence intensities measured being 9.2 × 1010 ± 2.5 × 1010 and 3.8 × 109 ± 1.6 × 109 p/s, respectively. By day 7, there was some migration of fluorescence away from the site of initial MN application. However, the majority of the body surfaces showed fluorescence levels that were comparable to those seen in the negative control group. This work suggests utility for polymeric MN arrays in minimally invasive intradermal delivery to enhance photodynamic therapy of deep skin lesions." @default.
• W2807451608 created "2018-06-13" @default.
• W2807451608 creator A5002441928 @default.
• W2807451608 creator A5007603731 @default.
• W2807451608 creator A5014790331 @default.
• W2807451608 creator A5035668087 @default.
• W2807451608 creator A5047247818 @default.
• W2807451608 creator A5076735770 @default.
• W2807451608 creator A5081151755 @default.
• W2807451608 date "2018-09-01" @default.
• W2807451608 modified "2023-10-16" @default.
• W2807451608 title "Intradermal Delivery of a Near-Infrared Photosensitizer Using Dissolving Microneedle Arrays" @default.
• W2807451608 cites W1170868200 @default.
• W2807451608 cites W1511449683 @default.
• W2807451608 cites W1909548258 @default.
• W2807451608 cites W1966399926 @default.
• W2807451608 cites W1967762287 @default.
• W2807451608 cites W1968420604 @default.
• W2807451608 cites W1974053849 @default.
• W2807451608 cites W1976287602 @default.
• W2807451608 cites W1977866244 @default.
• W2807451608 cites W1979156185 @default.
• W2807451608 cites W1981760171 @default.
• W2807451608 cites W1982320599 @default.
• W2807451608 cites W1992843088 @default.
• W2807451608 cites W1994318583 @default.
• W2807451608 cites W2020339036 @default.
• W2807451608 cites W2022302201 @default.
• W2807451608 cites W2024150485 @default.
• W2807451608 cites W2025534689 @default.
• W2807451608 cites W2028293737 @default.
• W2807451608 cites W2031892972 @default.
• W2807451608 cites W2038317671 @default.
• W2807451608 cites W2044750168 @default.
• W2807451608 cites W2047474960 @default.
• W2807451608 cites W2053176361 @default.
• W2807451608 cites W2053638145 @default.
• W2807451608 cites W2065845122 @default.
• W2807451608 cites W2066097192 @default.
• W2807451608 cites W2068291339 @default.
• W2807451608 cites W2072379171 @default.
• W2807451608 cites W2080078413 @default.
• W2807451608 cites W2084906892 @default.
• W2807451608 cites W2087793297 @default.
• W2807451608 cites W2107170752 @default.
• W2807451608 cites W2107857160 @default.
• W2807451608 cites W2108899627 @default.
• W2807451608 cites W2115080515 @default.
• W2807451608 cites W2117417850 @default.
• W2807451608 cites W2123890532 @default.
• W2807451608 cites W2127377584 @default.
• W2807451608 cites W2133222300 @default.
• W2807451608 cites W2134674865 @default.
• W2807451608 cites W2135000370 @default.
• W2807451608 cites W2138419609 @default.
• W2807451608 cites W2141301509 @default.
• W2807451608 cites W2145213448 @default.
• W2807451608 cites W2149196275 @default.
• W2807451608 cites W2161643519 @default.
• W2807451608 cites W2184528804 @default.
• W2807451608 cites W2497375873 @default.
• W2807451608 cites W4211024586 @default.
• W2807451608 cites W4638261 @default.
• W2807451608 doi "https://doi.org/10.1016/j.xphs.2018.05.017" @default.
• W2807451608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29864428" @default.
• W2807451608 hasPublicationYear "2018" @default.
• W2807451608 type Work @default.
• W2807451608 sameAs 2807451608 @default.
• W2807451608 citedByCount "20" @default.
• W2807451608 countsByYear W28074516082019 @default.
• W2807451608 countsByYear W28074516082020 @default.
• W2807451608 countsByYear W28074516082021 @default.
• W2807451608 countsByYear W28074516082022 @default.
• W2807451608 countsByYear W28074516082023 @default.
• W2807451608 crossrefType "journal-article" @default.
• W2807451608 hasAuthorship W2807451608A5002441928 @default.
• W2807451608 hasAuthorship W2807451608A5007603731 @default.
• W2807451608 hasAuthorship W2807451608A5014790331 @default.
• W2807451608 hasAuthorship W2807451608A5035668087 @default.
• W2807451608 hasAuthorship W2807451608A5047247818 @default.
• W2807451608 hasAuthorship W2807451608A5076735770 @default.
• W2807451608 hasAuthorship W2807451608A5081151755 @default.
• W2807451608 hasConcept C120665830 @default.
• W2807451608 hasConcept C121332964 @default.
• W2807451608 hasConcept C136229726 @default.
• W2807451608 hasConcept C150903083 @default.
• W2807451608 hasConcept C178790620 @default.
• W2807451608 hasConcept C185592680 @default.
• W2807451608 hasConcept C186807665 @default.
• W2807451608 hasConcept C192562407 @default.
• W2807451608 hasConcept C202751555 @default.
• W2807451608 hasConcept C207001950 @default.
• W2807451608 hasConcept C2777807558 @default.
• W2807451608 hasConcept C2779820397 @default.
• W2807451608 hasConcept C2781323092 @default.
• W2807451608 hasConcept C2781469039 @default.
• W2807451608 hasConcept C49040817 @default.
• W2807451608 hasConcept C55493867 @default.

• next