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- W2807470369 abstract "High doses of BCAA supplementation have unclear effects on cardiovascular diseases (CVD) biomarkers and energy metabolism in humans, even more when its associated to sprint interval training (SIT). PURPOSE: The aims of this study was to evaluate the effects of BCAA supplementation associated with SIT on energy metabolism and CVD biomarkers. METHODS: 40 overweight and sedentary volunteers (height: 169 ± 8cm; age: 32 ± 7 y; weight: 74.5 ± 10.7 Kg) were randomly distributed into 4 groups: S-PLA= sedentary + placebo; S-BCAA= sedentary + BCAA; SIT-PLA= SIT + placebo and, SIT-BCAA= SIT + BCAA. Supplementation was 300 mg/kg-1/dia-1 of BCAA (plus 200 mg/kg-1/dia-1 of maltodextrin) or 500 mg/kg-1/dia-1 of waxy maize (placebo), 3 times-a-day, for 8 weeks. During this period, SIT-PLA and SIT-BCAA groups did cycle ergometer training 3 days/ wk (4-8 sets of 30-s “all-out” bouts, with 4.5 min. recovery between sets). Pre- and post-treatment CVD biomarkers variables were evaluated: VO2peak, total cholesterol (TC) and their fractions (HDL and LDL), triglycerides, C-reactive protein (PCR), HbA1c, %BF, also respiratory exchange ratio (RER), blood glucose [Gl] and lactate [La] concentration, at rest and during exercise, as energy metabolism variables RESULTS: Post-treatment VO2peak increased (p<0.05) significantly in the SIT-PLA (95% CI: 2 to 7.6 mL.kg-1.min-1, Cohen’s d= 0.41) and SIT-BCAA (1 to 7.7, -0.50) groups only, with no difference between them; There was no treatment effect (p> 0.05) in %BF, TC and PCR in any groups; However, in the SIT-BCAA group only, there was a decrease (p<0.05) in HbA1c (-5.03 to -0.88%, 0.85), LDL (-42.90 to -1.03 mg/dl, 0.51) and an increase in HDL (2.91 to 18.85 mg/dl, -1.24), while triglycerides decreased (p<0.01) in both S-BCAA (-185.96 to -7.95 mg/dl, 1.09) and SIT-BCAA (-119.68 to -28.74 mg/dl, 1.19) groups only; Treatment effect was observed on RER which decreased in SIT-BCAA group only (p<0.01, n= 0.218) and tend to decrease in SIT-PLA group only (p= 0.06, n= 0.069); [Gl] decreased in S-BCAA (p<0.01, n= 0.440), SIT-PLA (p<0.01, n= 0.287) and SIT-BCAA (p<0.001, n= 0.460) groups only, with no difference between them; [La] decreased in SIT-PLA group only (p= 0.02, n= 0.220). CONCLUSIONS: BCAA supplementation associated with SIT promotes some synergistic changes on CVD biomarkers and energy metabolism." @default.
- W2807470369 created "2018-06-13" @default.
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- W2807470369 date "2018-05-01" @default.
- W2807470369 modified "2023-09-26" @default.
- W2807470369 title "High Doses Of Branched-chain Amino Acids Supplementation Associated To Sprint Interval Training Improves Metabolic Profile" @default.
- W2807470369 doi "https://doi.org/10.1249/01.mss.0000538713.98734.3f" @default.
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