FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807473407> ?p ?o ?g. }

• W2807473407 abstract "Abstract Dendritic cells (DCs) have a key role in orchestrating immune responses and are considered important targets for immunotherapy against cancer. In order to develop effective cancer vaccines, detailed knowledge of the micromilieu in cancer lesions is warranted. In this study, flow cytometry and human transcriptome arrays were used to characterize subsets of DCs in head and neck squamous cell tonsillar cancer and compare them to their counterparts in benign tonsils to evaluate subset-selective biomarkers associated with tonsillar cancer. We describe, for the first time, four subsets of DCs in tonsillar cancer: CD123 + plasmacytoid DCs (pDC), CD1c + , CD141 + , and CD1c − CD141 − myeloid DCs (mDC). An increased frequency of DCs and an elevated mDC/pDC ratio were shown in malignant compared to benign tonsillar tissue. The microarray data demonstrates characteristics specific for tonsil cancer DC subsets, including expression of immunosuppressive molecules and lower expression levels of genes involved in development of effector immune responses in DCs in malignant tonsillar tissue, compared to their counterparts in benign tonsillar tissue. Finally, we present target candidates selectively expressed by different DC subsets in malignant tonsils and confirm expression of CD206/MRC1 and CD207/Langerin on CD1c + DCs at protein level. This study descibes DC characteristics in the context of head and neck cancer and add valuable steps towards future DC-based therapies against tonsillar cancer." @default.
• W2807473407 created "2018-06-13" @default.
• W2807473407 creator A5002354967 @default.
• W2807473407 creator A5004367868 @default.
• W2807473407 creator A5016011628 @default.
• W2807473407 creator A5032522419 @default.
• W2807473407 creator A5065809036 @default.
• W2807473407 creator A5043590900 @default.
• W2807473407 date "2018-05-23" @default.
• W2807473407 modified "2023-10-12" @default.
• W2807473407 title "Profiling dendritic cell subsets in head and neck squamous cell tonsillar cancer and benign tonsils" @default.
• W2807473407 cites W137690307 @default.
• W2807473407 cites W1503585947 @default.
• W2807473407 cites W1541821188 @default.
• W2807473407 cites W1556058121 @default.
• W2807473407 cites W1582357464 @default.
• W2807473407 cites W1954436371 @default.
• W2807473407 cites W1971259949 @default.
• W2807473407 cites W1975996892 @default.
• W2807473407 cites W1978078815 @default.
• W2807473407 cites W1979402582 @default.
• W2807473407 cites W1987530836 @default.
• W2807473407 cites W1990956554 @default.
• W2807473407 cites W2004835017 @default.
• W2807473407 cites W2015812428 @default.
• W2807473407 cites W2016863609 @default.
• W2807473407 cites W2019308455 @default.
• W2807473407 cites W2039248453 @default.
• W2807473407 cites W2050216284 @default.
• W2807473407 cites W2058319961 @default.
• W2807473407 cites W2058934410 @default.
• W2807473407 cites W2062254683 @default.
• W2807473407 cites W2087508704 @default.
• W2807473407 cites W2096301496 @default.
• W2807473407 cites W2097581069 @default.
• W2807473407 cites W2099697271 @default.
• W2807473407 cites W2102498159 @default.
• W2807473407 cites W2105137247 @default.
• W2807473407 cites W2105541044 @default.
• W2807473407 cites W2122901629 @default.
• W2807473407 cites W2125533152 @default.
• W2807473407 cites W2127925922 @default.
• W2807473407 cites W2129152169 @default.
• W2807473407 cites W2137854382 @default.
• W2807473407 cites W2148531142 @default.
• W2807473407 cites W2151960221 @default.
• W2807473407 cites W2153135025 @default.
• W2807473407 cites W2161081695 @default.
• W2807473407 cites W2301531282 @default.
• W2807473407 cites W2403041597 @default.
• W2807473407 cites W2415001531 @default.
• W2807473407 cites W2480831986 @default.
• W2807473407 cites W2519093943 @default.
• W2807473407 cites W2523717546 @default.
• W2807473407 cites W2535141202 @default.
• W2807473407 cites W2583842811 @default.
• W2807473407 cites W2605810679 @default.
• W2807473407 cites W2770901637 @default.
• W2807473407 cites W2778028626 @default.
• W2807473407 doi "https://doi.org/10.1038/s41598-018-26193-y" @default.
• W2807473407 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5966442" @default.
• W2807473407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29795118" @default.
• W2807473407 hasPublicationYear "2018" @default.
• W2807473407 type Work @default.
• W2807473407 sameAs 2807473407 @default.
• W2807473407 citedByCount "13" @default.
• W2807473407 countsByYear W28074734072018 @default.
• W2807473407 countsByYear W28074734072020 @default.
• W2807473407 countsByYear W28074734072021 @default.
• W2807473407 countsByYear W28074734072022 @default.
• W2807473407 countsByYear W28074734072023 @default.
• W2807473407 crossrefType "journal-article" @default.
• W2807473407 hasAuthorship W2807473407A5002354967 @default.
• W2807473407 hasAuthorship W2807473407A5004367868 @default.
• W2807473407 hasAuthorship W2807473407A5016011628 @default.
• W2807473407 hasAuthorship W2807473407A5032522419 @default.
• W2807473407 hasAuthorship W2807473407A5043590900 @default.
• W2807473407 hasAuthorship W2807473407A5065809036 @default.
• W2807473407 hasBestOaLocation W28074734071 @default.
• W2807473407 hasConcept C121608353 @default.
• W2807473407 hasConcept C126322002 @default.
• W2807473407 hasConcept C142724271 @default.
• W2807473407 hasConcept C203014093 @default.
• W2807473407 hasConcept C2776444015 @default.
• W2807473407 hasConcept C2776530083 @default.
• W2807473407 hasConcept C2777701055 @default.
• W2807473407 hasConcept C2778170410 @default.
• W2807473407 hasConcept C2779419017 @default.
• W2807473407 hasConcept C2780674031 @default.
• W2807473407 hasConcept C502942594 @default.
• W2807473407 hasConcept C553184892 @default.
• W2807473407 hasConcept C71924100 @default.
• W2807473407 hasConcept C86803240 @default.
• W2807473407 hasConcept C8891405 @default.
• W2807473407 hasConceptScore W2807473407C121608353 @default.
• W2807473407 hasConceptScore W2807473407C126322002 @default.
• W2807473407 hasConceptScore W2807473407C142724271 @default.
• W2807473407 hasConceptScore W2807473407C203014093 @default.
• W2807473407 hasConceptScore W2807473407C2776444015 @default.
• W2807473407 hasConceptScore W2807473407C2776530083 @default.

• next