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- W2807476445 endingPage "567" @default.
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- W2807476445 abstract "Liver sinusoidal endothelial cells (LSECs) line the low shear, sinusoidal capillary channels of the liver and are the most abundant non-parenchymal hepatic cell population. LSECs do not simply form a barrier within the hepatic sinusoids but have vital physiological and immunological functions, including filtration, endocytosis, antigen presentation and leukocyte recruitment. Reflecting these multifunctional properties, LSECs display unique structural and phenotypic features that differentiate them from the capillary endothelium present within other organs. It is now clear that LSECs have a critical role in maintaining immune homeostasis within the liver and in mediating the immune response during acute and chronic liver injury. In this Review, we outline how LSECs influence the immune microenvironment within the liver and discuss their contribution to immune-mediated liver diseases and the complications of fibrosis and carcinogenesis. Liver sinusoidal endothelial cells (LSECs) represent the most abundant non-parenchymal hepatic cell population. In this Review, the authors explore the key roles that LSECs have in regulating hepatic immunity and their contribution to immune-mediated disease, liver fibrosis and carcinogenesis." @default.
- W2807476445 created "2018-06-13" @default.
- W2807476445 creator A5073689179 @default.
- W2807476445 creator A5079297632 @default.
- W2807476445 creator A5089964461 @default.
- W2807476445 date "2018-05-29" @default.
- W2807476445 modified "2023-10-11" @default.
- W2807476445 title "Liver sinusoidal endothelial cells — gatekeepers of hepatic immunity" @default.
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