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• W2807481092 abstract "Flow‐mediated vasodilation (FMD) is used for assessment of vascular endothelial function in humans as a predictor of cardiovascular events. It has been challenging to carry it on preclinical murine models due to the diminutive size of the femoral artery. Here, we present a new approach to accurately measure the blood velocity and femoral artery diameters of mice by acquiring Doppler optical coherence tomography and optical coherence tomography angiography continuously within 1 single experimental scanning protocol. Using the 3‐dimensional imaging and new velocity algorithm, the measurement precision of diameter, blood flow, velocity and wall shear stress are improved to 0.91%, 11.0%, 10.7% and 14.0%, respectively. FMD of healthy mouse femoral artery measured by this method was 11.96% ± 0.98%, which was blunted to 5.69% ± 0.4% by intravenous administration of endothelial nitric oxide synthase inhibitor (L‐N G ‐Nitroarginine methyl ester), in agreement with that reported in the literature." @default.
• W2807481092 created "2018-06-13" @default.
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• W2807481092 date "2018-06-28" @default.
• W2807481092 modified "2023-10-14" @default.
• W2807481092 title "Measurement of flow-mediated dilation of mouse femoral artery in vivo by optical coherence tomography" @default.
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• W2807481092 doi "https://doi.org/10.1002/jbio.201800053" @default.
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