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• W2807501265 abstract "ABSTRACT One deficit associated with schizophrenia (SZ) is the reduced ability to distinguish sensations resulting from self-caused actions from those due to external sources. This reduced sense of agency (SoA, awareness of ownership over self-generated actions) is hypothesized to result from a diminished utilization of internal monitoring signals of self-movement (i.e., efferent copy) which subsequently impairs forming and utilizing sensory prediction errors (differences between the predicted and actual sensory consequences resulting from movement). Here, we investigated the connections between clinical SZ symptoms and motor adaptation, a process that uses sensory prediction errors to update motor output. Schizophrenia patients (SZP, N=30) and non-psychiatric healthy control subjects (HC, N=31) adapted to altered movement visual feedback, and then applied the motor recalibration to untested contexts (i.e., the spatial generalization to untrained targets). Although adaptation was similar for SZP and controls, the extent of generalization was significantly less for SZP; movement trajectories made by patients to the furthest untrained target (135°) before and after adaptation were largely indistinguishable. Interestingly, deficits in the generalization were correlated to positive symptoms of psychosis (e.g., hallucinations), but not negative symptoms. Generalization was also associated with subjective measures of SoA across both SZP and HC, emphasizing the major role action awareness plays in motor behavior, and suggesting that tendencies to misattribute agency, even in HC, manifest in abnormal motor performance. We discuss the possible link of these findings to cerebellar circuit abnormalities that may be a common source for deficits in the utilization of sensory prediction errors and aberrant SoA." @default.
• W2807501265 created "2018-06-13" @default.
• W2807501265 creator A5049665568 @default.
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• W2807501265 creator A5084542477 @default.
• W2807501265 date "2018-06-04" @default.
• W2807501265 modified "2023-09-26" @default.
• W2807501265 title "Reduced transfer of visuomotor adaptation is associated with aberrant sense of agency in Schizophrenia" @default.
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• W2807501265 doi "https://doi.org/10.1101/338509" @default.
• W2807501265 hasPublicationYear "2018" @default.
• W2807501265 type Work @default.
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