Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807511912> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2807511912 endingPage "e194" @default.
- W2807511912 startingPage "e194" @default.
- W2807511912 abstract "Objective: PCOS and vitamin D deficiency are both frequent multifactorial endocrine disorders, lead to metabolic and early cardiovascular complications. According to actual data, there are an estimated 10.5 million fertile women suffering from PCOS only in the US. With this study we would like to describe the biomechanical changes of small coronary arterioles leading to a higher risk of cardial and cerebral insult. Design and method: 46 adolescent (21–28 day-old), 90–110 gramm-weighed female Wistar rats were grouped randomly in 4 groups: 24 animals recieved vitamin D supplemented diet, from which 12 animals went under transdermal testosterone treatment. 22 animals recieved vitamin D deficient diet, from which 11 were treated with testosterone. After 8 weeks of treatment, arterioles (in vivo diameter of 100–200 micrometer) from left anterior coronary artery were obtained. Isolated coronary arterioles were examined, in vitro, with pressure miography method. With videomicroscopic angiometry the inner and outer radii of the arteriole was evaluated. Such biomechanical properties as normal myogenic, maximal passive vasorelaxative and vasoconstrictive tone of the arterioles were obtained and statistically analysed. Results: In coronary arterioles, actual vitamin D status with and without testosterone supplementation caused significant differences in the vessel's maximal smooth muscle relaxant potential, tromboxane induced contraction capacity and normal myogenic tone. Conclusions: The novel finding of our study was, that the vitamin D deficency could lead to eutrophic remodelling and myogenic adaptation failure, which can elevate the risk of cardiovascular events. Supplementation of vitamin D could improve myogenic tone and relaxation, which hold cardiovascular benefits." @default.
- W2807511912 created "2018-06-13" @default.
- W2807511912 creator A5022155230 @default.
- W2807511912 creator A5028916660 @default.
- W2807511912 creator A5030244265 @default.
- W2807511912 creator A5048065981 @default.
- W2807511912 creator A5066348948 @default.
- W2807511912 creator A5081615752 @default.
- W2807511912 creator A5086011600 @default.
- W2807511912 creator A5030348458 @default.
- W2807511912 date "2018-06-01" @default.
- W2807511912 modified "2023-09-26" @default.
- W2807511912 title "BIOMECHANICAL PROPERTIES OF SMALL CORONARY ARTERIOLES IN VITAMIN D DEFFICIENCY AND PCOS" @default.
- W2807511912 doi "https://doi.org/10.1097/01.hjh.0000539537.70662.d0" @default.
- W2807511912 hasPublicationYear "2018" @default.
- W2807511912 type Work @default.
- W2807511912 sameAs 2807511912 @default.
- W2807511912 citedByCount "0" @default.
- W2807511912 crossrefType "journal-article" @default.
- W2807511912 hasAuthorship W2807511912A5022155230 @default.
- W2807511912 hasAuthorship W2807511912A5028916660 @default.
- W2807511912 hasAuthorship W2807511912A5030244265 @default.
- W2807511912 hasAuthorship W2807511912A5030348458 @default.
- W2807511912 hasAuthorship W2807511912A5048065981 @default.
- W2807511912 hasAuthorship W2807511912A5066348948 @default.
- W2807511912 hasAuthorship W2807511912A5081615752 @default.
- W2807511912 hasAuthorship W2807511912A5086011600 @default.
- W2807511912 hasConcept C124490489 @default.
- W2807511912 hasConcept C126322002 @default.
- W2807511912 hasConcept C12722491 @default.
- W2807511912 hasConcept C134018914 @default.
- W2807511912 hasConcept C164705383 @default.
- W2807511912 hasConcept C2779482390 @default.
- W2807511912 hasConcept C71924100 @default.
- W2807511912 hasConceptScore W2807511912C124490489 @default.
- W2807511912 hasConceptScore W2807511912C126322002 @default.
- W2807511912 hasConceptScore W2807511912C12722491 @default.
- W2807511912 hasConceptScore W2807511912C134018914 @default.
- W2807511912 hasConceptScore W2807511912C164705383 @default.
- W2807511912 hasConceptScore W2807511912C2779482390 @default.
- W2807511912 hasConceptScore W2807511912C71924100 @default.
- W2807511912 hasIssue "Supplement 1" @default.
- W2807511912 hasLocation W28075119121 @default.
- W2807511912 hasOpenAccess W2807511912 @default.
- W2807511912 hasPrimaryLocation W28075119121 @default.
- W2807511912 hasRelatedWork W141873526 @default.
- W2807511912 hasRelatedWork W1975759361 @default.
- W2807511912 hasRelatedWork W2009745211 @default.
- W2807511912 hasRelatedWork W2071103727 @default.
- W2807511912 hasRelatedWork W2107762597 @default.
- W2807511912 hasRelatedWork W2130345620 @default.
- W2807511912 hasRelatedWork W2141069430 @default.
- W2807511912 hasRelatedWork W2147487489 @default.
- W2807511912 hasRelatedWork W2151255529 @default.
- W2807511912 hasRelatedWork W4229053620 @default.
- W2807511912 hasVolume "36" @default.
- W2807511912 isParatext "false" @default.
- W2807511912 isRetracted "false" @default.
- W2807511912 magId "2807511912" @default.
- W2807511912 workType "article" @default.