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- W2807529610 abstract "The mechanisms leading to the development of premature atherosclerosis and vascular injury in systemic lupus erythematosus (SLE) remain to be fully elucidated. This is a comprehensive review of recent research developments related to the understanding of cardiovascular disease (CVD) in lupus.SLE patients with lupus nephritis display significantly increased risk of myocardial infarction and CVD mortality than SLE patients without lupus nephritis. SLE disease-related parameters could be taken into consideration when calculating CVD risks. The type I interferon pathway is detrimental to the vasculature and may contribute to the development of insulin resistance. The level of low-density granulocytes, a distinct subset of proinflammatory neutrophils present in SLE, was independently associated with coronary plaque burden and endothelial dysfunction. Invariant natural killer T cells may promote an atheroprotective effect in SLE patients with asymptomatic atherosclerotic plaques. Oxidized lupus high-density lipoprotein promotes proinflammatory responses in macrophages.Recent discoveries have further strengthened the critical role of SLE-related immune dysregulation and metabolic disturbances in promoting accelerated CVD. Understanding how these pathogenic factors promote vascular injury may provide better molecular candidates for therapeutic targeting, and ultimately to improve CVD outcomes." @default.
- W2807529610 created "2018-06-13" @default.
- W2807529610 creator A5010407321 @default.
- W2807529610 creator A5079115940 @default.
- W2807529610 date "2018-09-01" @default.
- W2807529610 modified "2023-10-03" @default.
- W2807529610 title "Cardiovascular disease in systemic lupus erythematosus: an update" @default.
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- W2807529610 doi "https://doi.org/10.1097/bor.0000000000000528" @default.
- W2807529610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29870498" @default.
- W2807529610 hasPublicationYear "2018" @default.
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