FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807535581> ?p ?o ?g. }

• W2807535581 abstract "An increased incidence of imprint-associated disorders has been reported in babies born from assisted reproductive technology (ART). However, previous studies supporting an association between ART and an altered DNA methylation status of the conceived babies have been often conducted on a limited number of methylation sites and without correction for critical potential confounders. Moreover, all the previous studies focused on the identification of methylation changes shared among subjects while an evaluation of stochastic differences has never been conducted. This study aims to evaluate the effect of ART and other common behavioral or environmental factors associated with pregnancy on stochastic epigenetic variability using a multivariate approach.DNA methylation levels of cord blood from 23 in vitro and 41 naturally conceived children were analyzed using the Infinium HumanMethylation450 BeadChips. After multiple testing correction, no statistically significant difference emerged in the number of cord blood stochastic epigenetic variations or in the methylation levels between in vitro- and in vivo-conceived babies. Conversely, four multiple factor analysis dimensions summarizing common phenotypic, behavioral, or environmental factors (cord blood cell composition, pre or post conception supplementation of folates, birth percentiles, gestational age, cesarean section, pre-gestational mother's weight, parents' BMI and obesity status, presence of adverse pregnancy outcomes, mother's smoking status, and season of birth) were significantly associated with stochastic epigenetic variability. The stochastic epigenetic variation analysis allowed the identification of a rare imprinting defect in the locus GNAS in one of the babies belonging to the control population, which would not have emerged using a classical case-control association analysis.We confirmed the effect of several common behavioral or environmental factors on the epigenome of newborns and described for the first time an epigenetic effect related to season of birth. Children born after ART did not appear to have an increased risk of genome-wide changes in DNA methylation either at specific loci or randomly scattered throughout the genome. The inability to identify differences between cases and controls suggests that the number of stochastic epigenetic variations potentially induced by ART was not greater than that naturally produced in response to maternal behavior or other common environmental factors." @default.
• W2807535581 created "2018-06-13" @default.
• W2807535581 creator A5004286520 @default.
• W2807535581 creator A5014652532 @default.
• W2807535581 creator A5039654830 @default.
• W2807535581 creator A5050267989 @default.
• W2807535581 creator A5060980676 @default.
• W2807535581 creator A5064695597 @default.
• W2807535581 creator A5069350522 @default.
• W2807535581 creator A5073892131 @default.
• W2807535581 creator A5083863027 @default.
• W2807535581 creator A5090285020 @default.
• W2807535581 date "2018-06-08" @default.
• W2807535581 modified "2023-10-16" @default.
• W2807535581 title "Multifactorial analysis of the stochastic epigenetic variability in cord blood confirmed an impact of common behavioral and environmental factors but not of in vitro conception" @default.
• W2807535581 cites W1528121360 @default.
• W2807535581 cites W1805313678 @default.
• W2807535581 cites W1969792452 @default.
• W2807535581 cites W1975718971 @default.
• W2807535581 cites W1978847332 @default.
• W2807535581 cites W1984019586 @default.
• W2807535581 cites W1987180785 @default.
• W2807535581 cites W1995592778 @default.
• W2807535581 cites W1996431759 @default.
• W2807535581 cites W2001491388 @default.
• W2807535581 cites W2012913138 @default.
• W2807535581 cites W2020532282 @default.
• W2807535581 cites W2029261491 @default.
• W2807535581 cites W2030468760 @default.
• W2807535581 cites W2057557736 @default.
• W2807535581 cites W2060967135 @default.
• W2807535581 cites W2062411806 @default.
• W2807535581 cites W2063432099 @default.
• W2807535581 cites W2075057742 @default.
• W2807535581 cites W2076614741 @default.
• W2807535581 cites W2083598925 @default.
• W2807535581 cites W2098802325 @default.
• W2807535581 cites W2099721980 @default.
• W2807535581 cites W2101870168 @default.
• W2807535581 cites W2103957974 @default.
• W2807535581 cites W2104549677 @default.
• W2807535581 cites W2109075458 @default.
• W2807535581 cites W2111879149 @default.
• W2807535581 cites W2112484452 @default.
• W2807535581 cites W2116531048 @default.
• W2807535581 cites W2127552529 @default.
• W2807535581 cites W2136501174 @default.
• W2807535581 cites W2149922901 @default.
• W2807535581 cites W2168708557 @default.
• W2807535581 cites W2169029146 @default.
• W2807535581 cites W2178425085 @default.
• W2807535581 cites W2256016639 @default.
• W2807535581 cites W2264947754 @default.
• W2807535581 cites W2285639784 @default.
• W2807535581 cites W2316056004 @default.
• W2807535581 cites W2324966680 @default.
• W2807535581 cites W2330784827 @default.
• W2807535581 cites W2407097676 @default.
• W2807535581 cites W2416887325 @default.
• W2807535581 cites W2514759088 @default.
• W2807535581 cites W2520794405 @default.
• W2807535581 cites W2529509969 @default.
• W2807535581 cites W2556381214 @default.
• W2807535581 cites W2587150222 @default.
• W2807535581 cites W2599208506 @default.
• W2807535581 cites W2600840322 @default.
• W2807535581 cites W2605491015 @default.
• W2807535581 cites W2608239726 @default.
• W2807535581 cites W2619688957 @default.
• W2807535581 cites W2771498566 @default.
• W2807535581 doi "https://doi.org/10.1186/s13148-018-0510-3" @default.
• W2807535581 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5994106" @default.
• W2807535581 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29930742" @default.
• W2807535581 hasPublicationYear "2018" @default.
• W2807535581 type Work @default.
• W2807535581 sameAs 2807535581 @default.
• W2807535581 citedByCount "25" @default.
• W2807535581 countsByYear W28075355812018 @default.
• W2807535581 countsByYear W28075355812019 @default.
• W2807535581 countsByYear W28075355812020 @default.
• W2807535581 countsByYear W28075355812021 @default.
• W2807535581 countsByYear W28075355812022 @default.
• W2807535581 countsByYear W28075355812023 @default.
• W2807535581 crossrefType "journal-article" @default.
• W2807535581 hasAuthorship W2807535581A5004286520 @default.
• W2807535581 hasAuthorship W2807535581A5014652532 @default.
• W2807535581 hasAuthorship W2807535581A5039654830 @default.
• W2807535581 hasAuthorship W2807535581A5050267989 @default.
• W2807535581 hasAuthorship W2807535581A5060980676 @default.
• W2807535581 hasAuthorship W2807535581A5064695597 @default.
• W2807535581 hasAuthorship W2807535581A5069350522 @default.
• W2807535581 hasAuthorship W2807535581A5073892131 @default.
• W2807535581 hasAuthorship W2807535581A5083863027 @default.
• W2807535581 hasAuthorship W2807535581A5090285020 @default.
• W2807535581 hasBestOaLocation W28075355811 @default.
• W2807535581 hasConcept C104317684 @default.
• W2807535581 hasConcept C126322002 @default.
• W2807535581 hasConcept C150194340 @default.
• W2807535581 hasConcept C190727270 @default.
• W2807535581 hasConcept C2779234561 @default.

• next