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• W2807544263 abstract "Methods for brain microstructure imaging use biophysical models aiming to estimate the neurite density from dMRI. However, the approach relies on important assumptions. The 'neurite assumption' holds that both axons and dendrites exhibit fully anisotropic diffusion and can be represented by a 'stick' compartment. The 'density assumption' holds that proton density and relaxation properties are approximately equal across tissue compartments. In this study, we investigate these assumptions in healthy brain tissue and in white matter lesions. Data were acquired by going beyond conventional multi-shell dMRI to use 'b-tensor encoding' and multiple echo times. To test the neurite assumption, we compared signal representations of b-tensor data with knowledge from histology. Results showed that microscopic diffusion anisotropy is associated with myelin, and thus axons, rather than with neurites. To test the density assumption, we attempted to estimate separate compartment T2 and diffusion properties. Results showed that compartment-specific T2 times were ambiguous in the healthy brain, impeding unbiased 'density' estimations. Meanwhile, different compartment T2 times were estimated in white matter lesions. Finally, we tested whether the 'stick' fraction of constrained biophysical models could serve as a 'neurite density index'. Results showed that different constraints yielded different rankings of the same brain regions, wherefore most constrained 'stick' fractions cannot be indices across the healthy brain and white matter lesions. In conclusion, the results indicate that the neurite density cannot be estimated, or even indexed, over a useful range of conditions with clinical dMRI. Until the advent of models with well-validated constraints, we recommend using multidimensional encoding to improve specificity and signal representations for data analysis." @default.
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• W2807544263 date "2018-06-07" @default.
• W2807544263 modified "2023-09-28" @default.
• W2807544263 title "Can the neurite density be estimated with diffusion MRI? A multidimensional MRI study using b-tensor encoding and multiple echo times" @default.
• W2807544263 hasPublicationYear "2018" @default.
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